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Biomedical subjects

N Refsum

Publications and source records attributed to N Refsum.

11 recordsLinked to original sources
PubMed1987

Counselling patients on oral anticoagulant therapy--a pilot study.

On a 38-bed General Medicine Unit, 12 of 15 patients discharged on oral anticoagulant therapy required counselling during a 7-week period. The study indicates that all patients who were responsible for administration of their own drugs after discharge, needed counselling, whether they received anticoagulants prior to admission or not. On average, one hour per week was required to identify the patients, and one hour per patient was spent on counselling. Counselling selected patients provides the pharmacist with a defined role in relation to each patient. It can easily be expanded gradually to include other patients and/or by concomitant monitoring drug therapy.

Anticoagulants↗
PubMed1981

The effects of albumin-bound unsaturated fatty acids on platelets.

Unsaturated fatty acids (FA) were bound to human albumin in a molar ratio of 2 and were then added to platelet-rich plasma (PRP), increasing the total FA concentration by 1 mM. Separate FA and FA paired with di-homo-gamma-linolenic acid (DHLA) and arachidonic acid (AA), respectively, were incubated with PRP for 5 and 90 min, and platelet aggregation and platelet factor 3 (PF3) activity were measured. DHLA inhibited adenosine-diphosphate- and collagen-induced platelet aggregation after 5 min, an effect which was enhanced after 90 min. The effects of AA, which stimulated platelet aggregation and increased PF3 activity, were partially counteracted by DHLA after 90 min. When linoleic acid and AA were incubated with PRP in equimolar concentrations for 90 min, an inhibition of collagen-induced platelet aggregation was observed which was not observed after incubation with these FA separately. This study indicates that exogenous albumin-bound AA and DHLA may be used directly by the platelet cyclo-oxygenase pathway before significant incorporation into the platelet phospholipids has occurred.

Adolescent↗
PubMed1979

Platelet function and serum high density lipoproteins.

Two groups of healthy male subjects one with low (mean 1.03 mmol/l), and the other with normal (mean 1.80 mmol/l), concentrations of high density lipoprotein (HDL) cholesterol in plasma were investigated. A series of in vitro platelet function tests were performed in order to investigate a possible connection between low HDL concentration, which has been defined as an independent risk factor for the occurrence of CHD, and disturbances in platelet function. No significant differences in platelet function were observed between the two groups. A positive correlation was found between platelet factor 3 activity both in platelet rich and platelet poor plasma and the plasma concentration of HDL.

Adult↗
PubMed1978

Sensitivity and precision of activated partial thromboplastin time (APTT) methods. A multicenter study.

The Activated Partial Thromboplastin Time (APTT) test, Cephotest, was compared to other APTT methods in current use in 4 specialized coagulation laboratories. In 3 of 4 laboratories, the sensitivity of Cephotest was superior (P less than 0.001) to that of the local APTT method. There was no statistically significant difference between the APTT methods with regard to precision of repetitive testing. In each laboratory, the normal range of Cephotest was estimated on freshly collected plasma samples from healthy subjects. A mean value between 28.8 and 35.8 s, with a standard deviation of 1.1-3.3 s, was obtained. It is concluded that the composition of the APTT method if of importance for the sensitivity of this test, but does not influence the precision of repetitive testing to a significant degree. The use of a standardized reagent facilitates comparison of the results obtained with the APTT method from one laboratory to another.

Blood Coagulation Tests↗
PubMed1977

The relationship between Normotest and Thrombotest in patients on oral anticoagulant therapy.

Normotest (sample volume: 25 micronl) and Thrombotest were performed in parallel on 150 consecutive capillary blood samples from patients on long term oral anticoagulant therapy. The ratio of Normotest to Thrombotest decreased from 2.50 at a Thrombotest level of 5-5.5% to 1.95 at a Thrombotest level of 13-13.5%, indicating that the effects of PIVKA were more pronounced at lower levels of coagulation activity. The influence of varying sensitivity of the thromboplastin reagents to PIVKA is discussed. The therapeutic range of Thrombotest (5-10%) corresponded to a Normotest level of 12-20%.

Administration, Oral↗
PubMed1977

Gastric mucosal damage caused by plain and microencapsulated acetylsalicylic acid tablets in healthy subjects: a gastrocamera study.

In a randomized, cross-over study plain acetylsalicylic acid (ASA) tablet and microencapsulated ASA tablets were given in doses of 1 gram 3 times a day for 3 days to 8 healthy subjects with no previous gastrointestinal disturbances. Gastrocamera examinations were performed before the ASA treatment and 1--2 hours after the last dose of ASA. The gastric mucosa appeared macroscopically normal at all the control examinations; whereas musocal bleeding was evident in all the subjects after the ASA treatment. There was no statistically significant difference between the plain ASA and the microencapsulated ASA preparations. No correlation could be found between the ASA concentration in plasma and the gastric mucosal damage.

Adult↗