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N Reisby

Publications and source records attributed to N Reisby.

10 recordsLinked to original sources
PubMed1992

[Quality assurance in psychiatry].

The need for ensuring quality in psychiatry and the elements in the structure, process and outcome are described together with the terminology employed in this field. The internal and external methods of ensuring quality in psychiatry are mentioned and an example of "time monitoring" of the physician's time devoted to patient-related work in a psychiatric department is presented. This example shows that each patient can obtain ten minutes of direct contact during each working day at the very most. It is concluded that it is possible to establish standards for structure and the processes employed in treatment of psychiatric patients but that it is much more difficult to establish standards for the outcome. Establishment of quality ensurance programmes at local level is recommended but The Public Health Board, Danish Psychiatric Association and possibly the consumers' association should develop and assess the necessary methods.

Denmark↗
PubMed1976

Plasma levels and antidepressive effect of imipramine.

The relationship between the antidepressive effect of imipramine and the plasma concentrations of imipramine and the active metabolite desipramine was studied in 24 patients suffering from endogenous depression. After a placebo period of 7 days, the patients received imipramine, 75 mg 3 times a day. The dose was reduced in patients with pronounced side effects. Blood samples for drug assay were drawn in the morning, 15 hr after the last drug intake. Imipramine and desipramine in plasma were assayed by quantitative in situ thin-layer chromatography. Individual variations in plasma concentration were 20- to 30-fold in both imipramine and desipramine. Severity of depression was assessed on the Hamilton Rating Scale (HRS). Eleven of 12 patients who responded satisfactorily to the treatment (HRS post-treatment score less than 8) had plasma concentration of imipramine greater than or equal to 45 mug/L, and desipramine greater than 75 mug/L, whereas the 12 patients not responding satisfactorily (post-treatment score on HRS greater than or equal to 8) all had concentrations of imipramine or desipramine or both below these limits.

Adult↗