Biomedical subjects
Publications and source records attributed to N Rohr.
Explore the source record for details and available documents.
This report presents vascular surgical operations performed in Denmark 1983-1987, the first five years after the establishment of the speciality. The number of vascular surgical operations increased by 18 per cent during the five years to nearly 2,000 operations in 1987. Approximately 50 per cent of all vascular procedures were intraabdominal operations, while 30 per cent were peripheral reconstructions. In 1987 40 operations/100,000 inhabitants were made, a level considerably below the activity performed in the other Scandinavian countries. We conclude that vascular surgical activity will increase in Denmark in the years to come.
The course of blood pressure and antihypertensive treatment (AHT) was studied in 27 renal transplant recipients immunosuppressed with cyclosporine-A (CyA) as monotherapy. At the time of transplantation 13 patients received AHT and 14 were normotensive. The final outcome of transplantation and CyA immunosuppression was 19 patients without AHT, 4 with reduced AHT and 3 with unchanged doses of AHT, while in 1 case a de novo mild hypertension necessitated diuretic treatment.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Urinary tract infection and rejection in 48 renal transplant patients immunosuppressed with cyclosporine-A monotherapy were analysed. Urinary tract infection was diagnosed in 52% of the cases with Escherichia coli dominating. Urinary tract infection took a mild and relatively uncomplicated course as only one case of graft pyelonephritis caused graft nephrectomy and no influence on graft survival was observed (p greater than 0.05) in the infected cases in contrast to rejection episodes which caused a significantly reduced graft survival (p less than 0.01).
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
The course of 48 consecutive cadaveric renal transplantations immunosuppressed with Cyclosporine-A (CyA) as monotherapy in 3 different doses was retrospectively analysed. CyA doses were based on clinical observations. Overall one-year graft survival was 52% and for grafts immediate diuresing 82%. A dosage schedule of 12 mg CyA/kg/day seemed to secure graft function without any side effects to the patient.
The courses of 34 graft failures leading to graft nephrectomy in 19 patients were examined retrospectively. Cyclosporin (CsA) was the sole immunosuppressive in 70% of the cases, and azathioprine-prednisolone in 30%. Having diagnosed graft failure, the immunosuppressive treatment was continued for about 2-3 months and then tapered slowly. No deaths related to graft failure were recorded. In three cases a delay in graft nephrectomy caused complications such as sepsis and coagulopathy. We conclude that continuing immunosuppression a few months after having diagnosed graft failure may postpone or avoid graft nephrectomy while steroid withdrawal symptoms do not complicate the course at the time of graft failure.
The clinical indications for and the timing of removal of non-functioning cadaver kidney transplants were studied in 49 of 58 kidneys which had never functioned or which ceased to function in the period 1979-1982. The reason for graftectomy was rejection in 32 cases, rejection and graft infection in eight, surgical complications in eight cases and infection in one case. Nine of the 58 failed kidney grafts were not removed. Graftectomy was performed within a week after diagnosis of graft failure in 24 of the 49 cases. The clinical indications for graftectomy were compared with the morphologic observations in the grafts. Discrepancy was greatest in regard to diagnosis of rejection and primary renal artery thrombosis. Severe complications related to graft failure aggravated the condition in 17 patients and resulted in eight deaths. Based on the findings, a management schedule is proposed. It facilitates postponement or avoidance of graftectomy and minimizes the risk of complications relating to failure of graft function.
Parathyroid carcinoma is a slow growing tumor, and the patients most often die from complications to the hypercalcemia. Therefore, any attempt should be made to remove local recurrence and metastasis surgically, as medical treatment is disappointing. A case treated with extensive vascular surgery to the neck is reported.
The material from 100 consecutive aortic and mitral valve operations has been studied histologically with particular reference to the presence of amyloid deposits. Sixty seven per cent were positive (aortic 88%, mitral 45%). The simultaneous occurrence of calcification of the valves and amyloid degeneration as well as of calcification and hyalinization was significant. Similarly there was significantly more amyloid in the older age groups, as well as a significant correlation between the degree of hyalinization of the valve and amyloid. Thirty-two patients had previously suffered from rheumatic fever. The heart valves of these patients did not differ histologically from the others, whereas significantly more amyloid was observed in the stenotic mitral valves than in the mitral valves which were insufficient.
Twenty-five consecutive treated patients with traumatic lesions of upper extremity arteries are presented. All were males, and most were young and able-bodied. Simultaneous fracture and/or dislocation of bone was present in 17 of the 25 patients, nerve lesions in 14 and venous trauma in 7 patients. Serious injuries to other organs had occurred in 8 patients, 3 of whom had multi-trauma. Three patients died, 2 of them from injuries to other organs. Seven others underwent amputation of the limb. No amputation was necessitated by the arterial lesion only. The major causes of injury were traffic accidents (mostly involving motor-cycles) and industrial accidents. The rate of limb salvage in this patient series was 60%. All patients with traumatic arterial lesions should be seen as soon as possible by a vascular surgeon, even if there are serious injuries to other organs, so as to avoid unnecessary diagnostic procedures and optimize the prospects for arterial reconstruction.
Lymphocele is a rare complication after renal transplantation. The symptomatology, diagnosis and treatment have been reported by several authors [1-9]. The symptoms are often insidious, variable and may result in difficult diagnostic problems. In this paper we present three cases of lymphocele as a surgical complication observed among 190 cases of renal transplantation.