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Biomedical subjects

N Rosenfield

Publications and source records attributed to N Rosenfield.

13 recordsLinked to original sources
PubMed2001

N7: a novel multi-modality therapy of high risk neuroblastoma (NB) in children diagnosed over 1 year of age.

BACKGROUND: The N7 protocol for poor-risk neuroblastoma uses dose-intensive chemotherapy (as in N6 protocol [Kushner et al.: J Clin Oncol 12:2607-2613, 1994] but with lower dosing of vincristine) for induction, surgical resection and 2100 cGy hyperfractionated radiotherapy for local control, and for consolidation, targeted radioimmunotherapy with 131I-labeled anti-GD2 3F8 monoclonal antibody and immunotherapy with unlabeled/unmodified 3F8 (400 mg/m2). PROCEDURE: The chemotherapy consists of: cyclophosphamide 70 mg/kg/d x 2 and a 72-hr infusion of doxorubicin 75 mg/m2 plus vincristine 2 mg/m2, for courses 1, 2, 4, and 6; and cisplatin 50 mg/m2/d x 4 and etoposide 200 mg/m2/d x 3, for courses 3, 5, and 7. 131I-3F8 is dosed at 20 mCi/kg, which is myeloablative and therefore necessitates stem-cell support. RESULTS: Of the first 24 consecutive previously untreated patients more than 1 year old at diagnosis, 22 were stage 4 and two were unresectable stage 3 with MYCN amplification. Chemotherapy achieved CR/VGPR in 21 of 24 patients. Twenty patients to date have completed treatment with 131I-3F8, and 15 patients have completed all treatment. With a median follow-up of 19 months, 18 of 24 patients remain progression-free. CONCLUSIONS: Major toxicities were grade 4 myelosuppression and mucositis during chemotherapy, and self-limited pain and urticaria during antibody treatment. Late effects include hearing deficits and hypothyroidism.

Antibodies, Monoclonal↗
PubMed1994

MR signal characteristics of cadaveric bone allografts in three children with primary bone tumors treated with limb salvage therapy.

Three children with adult cadaveric bone allografts for the treatment of bone malignancies are presented. Follow-up magnetic resonance (MR) imaging demonstrated decreased signal on T1-weighted imaging and increased signal on T2-weighted imaging in the allograft without clinical evidence of recurrent disease. These signal characteristics appear to be a normal finding in cadaveric bone allografts and should not be mistaken for recurrence. The finding may reflect persistent marrow necrosis within the allograft marrow cavity.

Adolescent↗
PubMed1994

Highly effective induction therapy for stage 4 neuroblastoma in children over 1 year of age.

PURPOSE: To test the efficacy of a protocol for poor-risk neuroblastoma that builds on the following: (1) our favorable previously reported results with dose-intensive use of cyclophosphamide; (2) our retrospective analysis of neuroblastoma chemotherapy reports, which supported the value of high-dose cisplatin and etoposide (VP-16); and (3) the Goldie-Coldman hypothesis that rapid cytoreduction plus the use of non-cross-resistant chemotherapy combinations will decrease the risk of drug resistance. PATIENTS AND METHODS: The N6 protocol included seven courses of high-dose chemotherapy plus surgical resection of bulk disease. Courses 1, 2, 4, and 6 consisted of 6-hour intravenous infusions of cyclophosphamide 70 mg/kg/d on days 1 and 2 (ie, 140 mg/kg per course), a 72-hour intravenous infusion of doxorubicin 75 mg/m2 and vincristine 0.1 mg/kg beginning day 1, and vincristine 1.5 mg/m2 intravenous bolus on day 9. Courses 3, 5, and 7 consisted of 2-hour intravenous infusions of VP-16 200 mg/m2/d on days 1 to 3 (ie, 600 mg/m2 per course), and 1-hour intravenous infusions of cisplatin 50 mg/m2/d on days 1 to 4 (ie, 200 mg/m2 per course). Courses were to start after neutrophil counts reached 500/microL and platelet counts reached 100,000/microL. Response was defined by international criteria. RESULTS: Among 24 consecutive previously untreated patients diagnosed with stage 4 neuroblastoma at more than 1 year of age, 21 patients achieved a complete or very good partial remission; one patient had no evidence of disease except by iodine-131-metaiodobenzylguanidine (MIBG) scan, which was markedly improved; and one patient had resolution of extensive metastatic disease, but still had an incompletely resected primary tumor. The sole patient to have a poor response had clinical features at diagnosis that are atypical for neuroblastoma, namely, 8 years of age and an unknown primary tumor. Severe toxicities included myelosuppression, mucositis, and hearing deficits. CONCLUSION: The N6 approach reliably achieves significant cytoreduction against stage 4 neuroblastoma. This may eventuate in an improved cure rate, since consolidative treatments using myeloablative therapy, immunotherapy, or biologic response modifiers such as cis-retinoic acid are most likely to be effective against minimal residual disease.

Abdominal Neoplasms↗
PubMed1987

Usefulness of chest radiographs in children with acute lower respiratory tract disease.

To determine how frequently and under what circumstances the chest radiograph changes pre-x-ray diagnoses and plans for management of suspected acute lower respiratory tract disease, experienced pediatricians performed a three-phased sequential evaluation (observation, history, physical examination), determined an initial diagnosis and the need for a chest radiograph after each phase, and recorded pre- and post-x-ray diagnoses and plans of management. Of the 102 children evaluated, the chest radiograph resulted in a change of the pre-x-ray diagnosis in 21% and pre-x-ray management plans in 16%. In the majority of these cases, a diagnosis previously considered less likely was "ruled in" or therapy was instituted rather than withheld. More important, when the pattern of decision making was consistent, with the initial diagnosis and the need for a chest radiograph remaining the same throughout all phases, the chest radiograph resulted in a change of pre-x-ray diagnosis in five (10%) of 48 patients, compared with a change in 16 (30%) of 54 when the pattern was inconsistent (P less than 0.02). Similarly, when the pattern was consistent, the pre-x-ray management was modified in only three (6%) of 48 patients versus 13 (24%) of 54 inconsistent cases (P less than 0.015). Chest radiographs are least useful when information from sequential observation, history, and physical examination is consistent in suggesting the same diagnosis and need for a chest radiograph. Radiographs appear to have greater impact on diagnosis and management when any inconsistencies arise.

Acute Disease↗
PubMed1980

Evaluation of solitary simple renal cysts in children.

Because there is a proportionately higher incidence of solid renal neoplasm in children than in adults early operative intervention is more common in these cases. For this reason the most important consideration when evaluating children is to exclude the presence of a malignant neoplasms. The clinical features, radiologic manifestations and management of solitary simple renal cysts in 3 children are discussed. We suggest that the increased accuracy and availability of newer imaging techniques now permit this entity to be managed in a fashion similar to its more common adult counterpart. Surgical exploration should be reserved for those cases in which there is doubt as to the benign nature of the cyst.

Child↗
PubMed1978

Cholelithiasis and Wilson disease.

We have studied three children with Wilson disease who had clinical symptoms suggestive of cholecystitis as well as radiologic evidence of gallstones, subsequently proven at the time of laparotomy. The gallstones from the patients with Wilson disease had an appreciably higher content of cholesterol than gallstones from age-matched children with hemolytic disease. Since gallstones may be present for years before they produce clinical symptoms, young patients with Wilson disease should undergo routine investigation for the presence of stones; cholelithiasis should also be considered in the differential diagnosis of abdominal pain in such patients.

Child↗
PubMed1978

Presymptomatic diagnosis of adult onset polycystic kidney disease by ultrasonography.

Results of an ongoing prospective study of progeny of patients with adult-onset polycystic kidney disease using grey-scale ultrasound and high-dose nephrotomography are reported. Six asymptomatic subjects out of 17 at risk for polycystic kidney disease were found by ultrasonography to have multiple renal cysts; this included two unrelated children aged 18 months and 6 y who had normal high-dose nephrotomography. We suggest that ultrasonography may be the method of choice for presymptomatic detection of polycystic kidney disease. Serial studies of at-risk individuals by sonography will be useful in determining the earliest age of detection, the latest age of ultrasonography presentation, and in following the natural history of polycystic kidney disease.

Adolescent↗
PubMed1977

Intracranial calcifications in childhood leukemia. An association with systemic chemotherapy.

Children with acute lymphocytic leukemia were examined for evidence of intracranial calcifications with roentgenograms of the skull and computerized tomography. Of 39 children in their initial complete remission, ten were found to have subcortical cerebral calcifications. Significant associations were found between the presence of cerebral calcifications and systemic treatment with large cumulative doses of methotrexate.

Adolescent↗
PubMed1975

Choledochal cysts: roentgenographic techniques.

Twenty-four cases of choledochal cysts were reviewed. Only 7 cases were definitely diagnosed preoperatively: 3 by 131I rose bengal scanning, 2 by intravenous cholangiography, 1 by oral cholecystography, and 1 by 99mTc sulfur colloid scanning followed by angiography. The highest percentage of definitive positive examinations was found in the 131I rose bengal scan (3 of 4), but the study most helpful in suggesting the diagnosis in a general way was the upper gastrointestinal series. The more frequent use of 131I rose bengal scanning and ultrasound should increase diagnostic accuracy.

Adolescent↗