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Biomedical subjects

N Ryman

Publications and source records attributed to N Ryman.

33 records · Page 2Linked to original sources
PubMed1977

The frequency of recessive lethal heterozygotes among inidividuals obtained from inbred strains. A random-number simulation study.

In small and moderate sized inbred strains the variation with regard to the frequency of lethal heterozygotes is of such a magnitude that it is almost impossible to predict the degree of heterogeneity from one generation to another. This was shown from computer simulations of the generational variation in inbred strains maintained by full-sib matings at different breeding regimes. The results are discussed in relation to Haldane's theoretical derivations and to the practical implications with regard to strain keeping and to design and evaluation of experiments.

Animals↗
PubMed1976

Significance of genetic factors for the plasma insulin response to glucose in healthy subjects.

The intravenous glucose tolerance and plasma insulin response to glucose infusion were analysed in a twin and family material, comprising 279 healthy subjects. The relation between the blood glucose and plasma insulin values was studied by an analysis of the principal eigenvalues. The variables obtained were corrected for sex, age and weight, and standardized with regard to mean and variance. The results showed that at least four of the variables have appreciable familial correlations, corresponding to a heritability (h2) varying between 0.38 and 0.72. These correlations could not be accounted for by common environment alone. Thus, the beta cell function in normal man, as measured by a glucose challenge test, appears to be genetically regulated.

Adolescent↗
PubMed1975

A genetic analysis of the normal body-height growth and dental development in man.

A twin and family study on the significance of genetic factors for the variation in certain new variables of dental and body-height development is presented. Evidence of a rather strong genetic regulation of most of the variables was obtained from the analysis of the twins and sibs. The data on cousins did not allow any definite conclusions, and it was not possible to obtain a parent--offspring material. Therefore, the study did not give any information concerning the relative significance of additive genetic variation.

Adolescent↗