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Biomedical subjects

N S Kisliak

Publications and source records attributed to N S Kisliak.

At least 19 recordsLinked to original sources
PubMed1991

[Alloimmune neutropenia in newborns].

Investigations were conducted in 4 infants with alloimmune neutropenia caused by leuko-agglutinins (2 cases) and granulo-cytotoxins (2 cases) detected in the mothers' and infants' sera. Anti-granulocytic antibodies reacted with granulocytes of the child and father but did not react with the mother's own cells. A more severe clinical course (repeated pyo-inflammatory diseases, sepsis) was recorded in infants with alloimmune neutropenia caused by granulo-cytotoxins, alloimmune neutropenia was characterized by disorders in neutrophil phagocytic activity (mainly, due to decreased digestive capacity of cells), inhibition of colony-forming capacity of precursor-cells of granulocytopoiesis; a tendency to T-lymphocytopenia was noted during the study of cellular immunity parameters. Prognosis was favourable in all the cases of neutropenia. The maximum term of neutropenia duration was 6 months. The catamnesis has shown that the development of the infants is normal and they fall ill not often.

Autoimmune Diseases↗
PubMed1991

[Roentgenologic endovascular occlusion of the spleen in the treatment of hereditary spherocytic hemolytic anemia in children].

Roentgenoendovascular occlusion of the spleen has been suggested for the treatment of children with hereditary spherocytic hemolytic anemia as an alternative to splenectomy. The operation was conducted in 8 children aged from 1 to 11 years. Selective decontamination of the intestine was used for prevention of inflammatory complications. Occlusion of 60% of the splenic parenchyma results in a stable clinico-hematological effect and can be performed as a single stage. Young children could be operated on by this method.

Angiography↗
PubMed1991

[Evaluation of hematopoietic and stromal cells-precursors in children with neutropenia].

The content of hemopoietic and stromal precursor-cells was studied in the bone marrow of 46 children with congenital neutropenia and of 2 children with chronic benign neutropenia. It was found that the number of GM-CFC and F-CFC in the bone marrow of patients with chronic benign neutropenia did not differ from that in the control group of normal children, and the lowering of the neutrophil number in the blood was, probably, associated with their redistribution mechanism or increased destruction in the body. Multiple defects of hemopoietic and stromal tissue were detected in children with a hereditary form of congenital neutropenia when anomalous proliferation of F-CFC and disorders in GM-CFC differentiation led to hypoplasia of granulocytic growth stem and neutropenia.

Adolescent↗
PubMed1989

[Late (after 5-year remission) recurrences of acute leukemia in children (a cooperative study)].

Cooperative investigations were conducted in seven Pediatric Hematologic Clinics (in Moscow, Leningrad, Kiev, Minsk and Tbilisi) to study the nature of late (after five years of remission) relapses of acute leukemia that were diagnosed in 21.6% of cases (in 80 out of 371 children) with long-term remissions. Late relapses in most patients occurred on the 6-7th year of remission. In cases when the treatment was abolished, relapses took place 1-2 years after the abolition. Extramedullary foci of leukemic lesions (CNS, sexual glands, etc.) were detected more frequently (41 children). Bone marrow lesions were recorded in 21 combined relapses were observed in 8 patients. It has been stressed that initial risk factors should be taken into consideration, and current diagnostic tests should be applied to individualize therapy at all the stages of the treatment.

Acute Disease↗