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N S Kositsyn

Publications and source records attributed to N S Kositsyn.

47 records · Page 3Linked to original sources
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[Neurobiological approach to brain functional asymmetry in depression].

The modern literature data were observed, which dedicated to the study of neurobiological mechanisms of depressive states of different origin. The results of the investigations of structurally functional features of depression in healthy volunteers in experiments and in patients with the neurological diseases were viewed. The data cited confirm the modern concepts of R. Davidson concerning to the role of brain functional asymmetry in depression: i.e., the associations between depression and a decrease of the functional activation of the left prefrontal lobe, and also the involving of amygdale in the processes of the forming of negative emotions and depression. The literature data observed and findings of our investigations allow us to conclude that depressive states are characterized not only by the decrease of the functional activity of the left hemisphere, especially, its prefrontal area, but also reciprocal increase of the physiological activity of the prefrontal area of the right hemisphere combined with right-hemispheric functional insufficiency, especially, of its posterior (parieto-temporal) areas.

Amygdala↗
PubMedDate not supplied

[Mechanisms of neurogenic dystrophies induced by activation and deprivation of the sympathetic nervous system].

Entry of abnormal nervous stimuli after sciatic nerve transection proved to affect the functioning of renal mineralocorticoid receptors as a result of inadequate neurotrophic support of this organ. Drug blockade of both neural and humoral transmission of the abnormal stimuli from the injured nerve to the kidney prevented development of trophic disorders as indicated by the status of the renal mineralocorticoid receptor system. At the same time, drug stimulation of the sympathetic nervous system further affected aldosterone reception by this organ. beta-Blocker propranolol was shown to exert an antidystrophic effect in the case of local injuries of the neural system and, thus, prevented the development of neurogenic dystrophies.

Adrenergic beta-Antagonists↗
PubMedDate not supplied

[Neurobiological studies of gamma-band bioelectrical activity in humans].

The modem literature data were observed, which dedicated to the study of neurobiological studies of gamma-rhythm mechanisms, providing the cognitive functions in hymans: state of readiness and attention, providing of sensory indentification, perception and memorizations, decision-making, management of psychomotor response, emotional and semantic processing of an information. It was shown that synchronous gamma-activity is at integrative activity, which in deteriorated in pathology of thinking. Literature data were analysed concerning ot the changes of gamma-activity (spontaneous, evoked, provoked by photostimulation etc.) in a number of neuropsychiatric disorders: epilepsy, schizophrenia, Alzheimer's disease, attention deficit hyperactivity disorder, stroke etc. as compared with norm. The data observed testify to high significance of gamma-activity in the brain functioning.

Brain↗
PubMedDate not supplied

[Efficacy of cerebrolysin in cerebral hemorrhage model in rats].

The pharmacological efficacy of cerebrolysin (a brain-derived peptidergic drug) was studied in rats with a unilateral hemorrhagic stroke model. Cerebrolysin produces a neuroprotective effect, which is manifested by a decrease in the number of degenerated neurons in the vicinity of hematoma region in acute period and by a reduction of the neuronal loss in the early recovery phase. Besides, the administration of cerebrolysin improves the functional state as judged from the results of neurological and behavioral tests (open field, paw licking, and passive avoidance). A decrease in the hyperactivity in the open field test and the conservation of latent avoidance in the passive avoidance test demonstrate the drug influence on the maintenance of inhibitory processes deteriorated in stroke.

Amino Acids↗
PubMedDate not supplied

[The scientific legacy of P. K. Anokhin: its relationship to the ideas of "universal evolutionism" and its methodological importance for modern concepts of self-organization].

The association is considered between P. K. Anokhin's ideas and the concept of universal evolutionalism. The interrelation is also analyzed of P. K. Anokhin's concept with the theory of self-organizing systems. The present views on the self-organization principle are analyzed. The prerequisites of development are considered and the content is presented of the main principles of synergetics. A thesis is advanced about the incorrect application of the knowledge concerning self-organization of physicochemical systems to biological and social systems. A conclusion is substantiated that P. K. Anokhin's theory of functional systems is of important significance for development of a new trend in synergetics, i.e., neurosynergetics.

Animals↗