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Biomedical subjects

N S Sadick

Publications and source records attributed to N S Sadick.

51 records · Page 3Linked to original sources
PubMed1991

Acquired trichomegaly of the eyelashes: a cutaneous marker of acquired immunodeficiency syndrome.

Acquired trichomegaly of the eyelashes was found in seven patients infected with human immunodeficiency virus type 1. These patients had advanced infection with severe T-helper cell depletion, high levels of p24 antigenemia, and inability to tolerate zidovudine therapy. Control of infection with other antiretroviral agents caused the trichomegaly to regress. Acquired trichomegaly may be a useful clinical marker for assessment of severity of infection.

Acquired Immunodeficiency Syndrome↗
PubMed1991

Sclerotherapy of varicose and telangiectatic leg veins. Minimal sclerosant concentration of hypertonic saline and its relationship to vessel diameter.

The author reports the results of a double-blind, paired-comparison study using saline sclerosant plus or minus heparin additive. The study was designed to elucidate the effects of increasing concentrations of hypertonic saline with regard to vessel diameter, clinical efficacy, complications, and discomfort. Six hundred women with bilaterally symmetrical starburst telangiectasias or varicose veins were entered into the study. Sodium chloride 11.7% appeared to be the minimal sclerosant concentration of saline that produced the most effective vein sclerosis of vessels of less than 8 mm in diameter, while producing the least morbidity. The optimal concentration of the sclerosant may vary with the diameter of the vessels under therapeutic consideration.

Adolescent↗
PubMed1990

Cutaneous photosensitivity and coproporphyrin abnormalities in the Alagille syndrome.

Porphyria cutanea tarda-like blistering, fragility, and scarring of light-exposed skin was observed in four children with the Alagille syndrome. Abnormally elevated levels of serum porphyrins, of which coproporphyrin isomers I and III together accounted for 50%-89% of the total, were found in these four children but also in three other children with the Alagille syndrome without such skin lesions. The ratio for isomer I to III for total serum coproporphyrin concentration was determined in six cases; the concentration of isomer I was greater than or equal to that of isomer III in each case. Urinary total porphyrin excretion was found to be elevated in six of the seven cases, with 72% +/- 8% occurring as coproporphyrins I and III. The ratio for urinary coproporphyrin I to III was greater than or equal to 1 in six of these patients, the reverse of the typical normal isomer distribution. Inasmuch as the presence or absence of photocutaneous lesions did not correlate with levels of porphyrins in serum or urine, other factors may be involved in the pathogenesis of the skin lesions.

Adolescent↗
PubMed1990

Papulosquamous dermatoses of AIDS.

We review the spectrum of papulosquamous disorders in the setting of infection with the human immunodeficiency virus (HIV). Included is a discussion of xerosis generalisata, seborrheic dermatitis, psoriasis, pityriasis rosea-like eruption, keratoderma blennorrhagicum, acquired ichthyosis, and erythroderma. Mechanisms of pathogenesis, including possible common pathways and relationships to underlying immunosuppression, are emphasized.

Acquired Immunodeficiency Syndrome↗
PubMed1990

A study of estrogen and progesterone receptors in spider telangiectasias of the lower extremities.

There is an association of some vascular tumors with estrogen receptors and an association of vascular telangiectasias with high levels of circulating estrogen. Because of this, a study of patients with lower extremity starburst telangiectasias and predisposing factors associated with hyperestrogenemic and hyperprogesteronemic states was undertaken in order to look for estrogen and progesterone receptors in biopsy specimens of lower extremity telangiectasias noted to arise in this setting. Contrary to expected results, using immunocytochemical techniques, no patient in this study was found to have estrogen or progesterone receptors present in their lower extremity telangiectasias. Possible explanations for these results are discussed.

Adult↗
PubMed1989

Antipsoriatic effects of zidovudine in human immunodeficiency virus-associated psoriasis.

Four patients with psoriasis complicating human immunodeficiency virus (HIV) infection showed marked improvement in their psoriasis after being treated with oral zidovudine. The antipsoriatic effect persisted in two patients in spite of worsening helper T cell depletion. The antipsoriatic effect appeared to be dose-dependent and was associated with the development of erythrocyte macrocytosis, a known side effect of zidovudine. Zidovudine is useful for the therapy of HIV-associated psoriasis and should be tested for efficacy in non-HIV-associated psoriasis.

Acquired Immunodeficiency Syndrome↗
PubMed1989

A new technique for curvilinear scalp reduction.

A technique of alopecia reduction utilizing a curvilinear ellipse employing a sequential excision and suture technique is described. Advantages of the technique over previously described procedures are presented. Measurements of individual scalp elasticity and alternating suture tension vectors help to produce an excellent cosmetic result with minimal complications.

Alopecia↗
PubMed1988

Atrophie blanche in chronic myelogenous leukemia.

Atrophie blanche is a syndrome of painful vasculitic infarctive lesions of the lower extremities that heal leaving characteristic atrophic, porcelain white scars. The syndrome may occur as an idiopathic entity or associated with various hematologic and collagen vascular disorders. We present the first recognized case of atrophie blanche in a patient with chronic myelogenous leukemia. This presentation may be part of the expanding spectrum of nonspecific cutaneous manifestations of leukemia (leukemids).

Aged↗
PubMed1987

Comparison of detection of varicella-zoster virus by the Tzanck smear, direct immunofluorescence with a monoclonal antibody, and virus isolation.

A study comparing direct immunofluorescence assay using a new monoclonal antibody specific for a varicella-zoster virus glycoprotein complex, the Tzanck smear, and virus isolation for detection of varicella-zoster virus in 56 patients with clinically apparent herpes zoster is presented. Of 47 patients with clinical herpes zoster and with cultures negative for herpes simplex virus, 30 (64%) had positive Tzanck smears, direct immunofluorescence assay results were positive in 26 (55%), and cultures were positive in only 12 (26%). Both direct immunofluorescence assay and the Tzanck smear were found to be superior to culture technics; however, direct immunofluorescence assay was found to have greater specificity.

Antibodies, Monoclonal↗
PubMed1986

Kaposi's sarcoma of the penis in a patient with the acquired immune deficiency syndrome.

We report a case of secondary Kaposi's sarcoma of the penis and the acquired immune deficiency syndrome. Recognition of the penile lesion as being secondary Kaposi's sarcoma is paramount, since the clinical course appears to be dependent upon systemic disease. Local therapy is reserved for palliation upon disease recurrence.

Acquired Immunodeficiency Syndrome↗
PubMed1986

Adjuvant techniques in punch graft hair transplantation.

The authors present a study of 150 patients treated for male pattern alopecia by autograft punch transplantation. Factors found to improve results were diminished epinephrine concentration, use of a template spacing device, tunnelling, lack of fat trimming, saline instillation for harvesting donor grafts, injection of long-acting anesthetics, and blend grafting.

Adipose Tissue↗