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Biomedical subjects

N S Stoy

Publications and source records attributed to N S Stoy.

3 recordsLinked to original sources

Monocyte/macrophage initiation of organ-specific autoimmunity: the ultimate 'bystander' hypothesis?

It is postulated that organ-specific autoimmune diseases could be initiated by dysregulated peripherally activated monocytes/macrophages penetrating into target organs nonspecifically. Failure of regulation of pro-inflammatory monocytes/macrophages might then result in autoimmune disease if secondary over-expansion of pre-existing autoantigen-specific T cell populations occurs in genetically predisposed individuals.

Animals↗

Stroke and cholesterol: 'enigma variations'?

The relationship of raised serum cholesterol to coronary atherosclerosis, the main pathophysiological substrate for most ischaemic myocardial events, is clear. Strokes have a more complex aetiology. Hypertension and smoking are strong risk factors for stroke, and their elimination is effective in stroke prevention, but cholesterol has been regarded historically as a poor predictor of stroke incidence. The reasons for this are analysed and the relevance of serum cholesterol to stroke prevention discussed.

Adult↗