It has been shown in rat experiments that isonarcotic concentrations of inhalation anesthetics (pentane, hexane, heptane) varied in the brain depending on the regimen of monoanesthesia. It has been demonstrated that the high content of anesthetics in the priming mixture results in a decline of the isoeffective brain concentration. Preliminary anesthesia leads to an increase in this indicator. The data obtained are accounted for by distributive processes in the biophase-adjacent structure system.

Anesthesia, Inhalation↗

PubMedDate not supplied

[Fluorothane pharmaco kinetics in brain structures and the permeability of the hemato-encephalic barrier in postnatal ontogeny].

Distribution of ftorotan in the brain structures (hemispheres, thalamus, cerebellum, limbic structures) and blood, and permeability of the blood brain barrier of the listed brain structures were studied by gas chromatography in postnatal ontogenesis (7, 17, 30, 60 and 90 days) of white rats during three stages of anesthesia -- initial, "surgical" and final ones. It has been established that the histohematic barrier is most permeable prior to 17-day age; the blood brain barrier is the least permeable in 7- and 17-day-old animals. Sorption of the brain tissue increases after 17 days and reaches maximum by day 90 of the postnatal development.

Animals↗

PubMedDate not supplied

[Isoniazid distribution and biogenic amine metabolism in brain structures].

The effect of isoniazid (200 mg/kg) on metabolism of biogenic amines in different parts of the brain was studied in acute experiments on white rats. Isoniazid was detected in all test organs one hour after the administration, with metabolism of biogenic amines changed. The level of biogenic amines is related not only to the drug distribution pattern but also to the specificity of its participation in the biochemical processes, restricting the synthesis of monoamines.

Animals↗

PubMedDate not supplied

[Brain structural monoamines under inhalation anesthesia].

It was established in albino rats that the activity of the processes that are responsible for the functioning of the metabolic link in noradrenaline synthesis varies under ether and ftorotan anesthesia. It was recorded that there is an increase in the activity of DOPA decarboxylation in the brain under deep ether anesthesia as well as in the activity of dopamine decarboxylation during egress from anesthesia. Ftorotan anesthesia is characterized by increased hydroxylation of phenylalanine and decarboxylation of DOPA, and by inhibition of the activity of tyrosine and dopamine hydroxylation. Egress of animals from ftorotan anesthesia is associated with an intensive noradrenaline formation in the brain.

Anesthesia, Inhalation↗