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Biomedical subjects

N S Titova

Publications and source records attributed to N S Titova.

At least 19 recordsLinked to original sources
PubMed1991

[The cytochemical marking of lymphocyte subpopulations in determining the immunoreactivity status of children vaccinated with a live measles vaccine].

In 54 children aged 1.5-2 years, immunized with the same batch of live measles vaccine prepared from strain, the relative and absolute numbers of different lymphocyte subpopulations were determined in parallel by means of two cytochemical reactions: for acid alpha-naphthyl acetate esterase and acid phosphatase in their dynamics. According to the data obtained in these reactions, the determination of lymphocyte subpopulations by two cytochemical methods in the same blood sample yielded similar results indicating that immunization with attenuated measles virus strain induced a rise in the number or zero lymphocytes and was accompanied by the decrease of the immunoregulatory index (T-helper/T-suppressor ratio), most pronounced in children with a high level of antibody formation.

Acid Phosphatase↗
PubMed1990

[The dynamics of the T-lymphocyte subpopulations and the peroxidase activity of the neutrophils in children immunized with a live mumps vaccine].

The amount of T-helpers and T-suppressors and the T-helper/T-suppressor ratio were determined in 30 practically healthy children aged 1.5-2 years, immunized with live parotitis vaccine prepared from strain -3. One immunization dose of the vaccine contained 7,950 HADU50. In all children peroxidase activity in the cytoplasm of neutrophils was studied. This investigation revealed that in all examined children the formation of immune response to immunization with live parotitis vaccine was accompanied by the development of an imbalance of immunoregulatory T-cell subpopulations and by functional changes in neutrophils, characterized by the inhibition of peroxidase activity. The changes revealed in this study were most pronounced in children with a high level of antibody formation.

Antibodies, Viral↗
PubMed1989

[Macrophage transformation of mononuclear cells following primary and secondary experimental immunization with measles vaccine].

Cell-mediated and humoral immune response was studied in guinea pigs receiving two immunizations with live measles vaccine l-16 in doses of 1000 TCD50/0.5 ml at an interval of 45 days. The results of this study showed that the maximum level of the macrophagal transformation of mononuclears and the most intensive synthesis of antimeasles antibodies were observed on day 10 after booster immunization. The intensification of cell-mediated and humoral immune response was found to depend on the initial immunological background. The animals having had high values of cell-mediated response before booster immunization showed a decrease in these values, while an increase in antibody titers in such animals was transitory.

Animals↗
PubMed1988

[Prevention of mumps in preschool institutions using a live mumps vaccine made from strain L-3].

The effectiveness of the emergency vaccinal prophylaxis of epidemic parotitis was studied in 19 children's day-care centers. As revealed in this study, the immunological effectiveness of vaccination did not depend on the age of vaccinees, but sharply decreased if live parotitis vaccine contained less than 10,000 HADU50 per immunization dose. After a single administration of the vaccine 91.1 +/- 0.98% of children were found to produce mumps antibodies. The immunization of children with live parotitis vaccine prepared from strain l-3 immediately after the first case of parotitis had been registered proved to be a highly effective measure. The coefficient of epidemiological effectiveness was 96.4%.

Antibodies, Viral↗
PubMed1986

[Measles morbidity among children inoculated against this infection].

In the serological survey of 2009 children immunized against measles 285 children (14.2%) were found to be seronegative to this infection in the hemagglutination inhibition test with 4 hemagglutinating units of the antigen. Among 1724 immunized children showing positive response to vaccination and placed under dynamic observation for 11 years, 2 cases of measles were registered. At the same time, in the dynamic observation of 111 seronegative children 66 measles cases (59.5%) were registered during the above period, while among 169 children, also seronegative, but receiving booster immunization against measles, morbidity rate was only 1.2%. In some vaccinees the decrease of postvaccinal immunity to seronegative values was observed, but such decrease had no essential influence on the morbidity level among the vaccines. The increase of measles morbidity among schoolchildren immunized against this infection was due not to the decrease of their postvaccinal immunity, but to their concentration in schools and to their more intensive contacts with the sources of infection in comparison with children of preschool age.

Antibodies, Viral↗
PubMed1986

[Epidemiologic surveillance of diphtheria and measles].

The epidemiological surveillance of diphtheria and measles makes it possible to evaluate the actual coverage of different groups of population with immunization and the state of this protection, to determine the tendencies of the epidemic processes of the afore-mentioned infections, to assess the efficacy of prophylactic and antiepidemic measures, and to develop well-grounded recommendations aimed at preventing the formation of foci of group infections and the lethal outcomes of diphtheria and measles.

Adolescent↗
PubMed1985

[Immunocytochemical indices of the measles vaccinal process].

To study the immune responsiveness of children in the measles vaccinal process, the cytochemical methods for the identification of immunocompetent cells have been used. The investigations have been made in children aged 1.5-4 years, immunized with live measles vaccine prepared from strain l-16. The results of these investigations indicate that the development of specific antiviral postvaccinal immunity is characterized by transitory changes in the populations of T-, B- and O-lymphocytes; such changes are accompanied by not only quantitative, but also qualitative changes of individual populations.

Acid Phosphatase↗
PubMed1984

[Immunological effectiveness of a booster inoculation against measles in children remaining seronegative after vaccination].

Booster immunization against measles with a highly immunogenic vaccine leads to the development of prolonged postvaccinal immunity lasting at least 6-7 years (the term of observation) in the groups of children found to be seronegative after the titration of their blood sera with 1 hemagglutinating unit (HAU) of the antigen. The booster immunization of children in whose blood sera the minimal concentrations of antibodies can be determined in the presence of 1 HAU of the antigen (seronegative in the presence of 4 HAU) is less effective. The serological checks of immunized children entering preschool institutions and the primary grades at schools and the subsequent booster immunization of children found to be seronegative will lead to a further decrease in measles morbidity.

Antibodies, Anti-Idiotypic↗