PubMed Health⌕ Search

Biomedical subjects

N S Zaĭtseva

Publications and source records attributed to N S Zaĭtseva.

At least 19 recordsLinked to original sources
PubMed2006

[Medico-genetic prediction of cerebral stroke risk].

A population family study including 1410 residents of Rostov region (280 families) was conducted. The study included questioning and analysis of medical records for the presence or absence of chronic diseases, including cardiovascular pathology, arterial hypertension, coronary heart disease, diabetes mellitus, and their complications, cerebral stroke (CS) and myocardial infarction, as well as the time of their occurrence. Statistic analysis included conventional descriptive statistics and regressive analysis, as well as a special part, population genetic analysis. The results showed that MI mortality was 21.4 times higher in the group of a high genotypic risk vs. the low risk group, 8.1 and 0.38%, respectively. The authors developed tools of MI risk prediction depending on hereditary burden, the use of which present a significant addition to the conventional system of phenotypic risk assessment. In order to adapt calculations to practical healthcare, the authors developed risk charts which allow MI risk assessment according to the magnitude of risk factors.

Catchment Area, Health↗
PubMed2003

[Disorders in the immune regulation and hemostasis as factors triggering the proliferative retinopathy in diabetes mellitus].

A comprehensive clinical- immunological- and-hemostasiological study of the lachrymal fluid and blood of 105 patients with diabetic retinopathy (DR) showed that an "extreme" activity of the local antibody-dependent response to collagens, DNA, cytokine, TNF-alpha, increased levels of the circulating immune complexes (CIC) and of antibodies to DNA in the blood serum as well as local immune insufficiency and deficiency of free antibodies to collagens and TNF-alpha in the lachrymal fluid and serum during the onset of proliferative forms and traction retinal detachment are the key manifestations of the immune pathology in a progressing DR. Signs of hypercoagulation, free heparin deficiency, a reduced activity of fibrinolysis and insufficiency of the anti-thrombin system were detected with the development of the chronic syndrome of disseminated intravascular blood coagulation. Trends of the immunohemostatic correction of the activity of the local and systemic autoimmune responses and of hemostasis were substantiated during the generally accepted therapy of diabetes mellitus and of systemic micro- and-macroangiopathy.

Adolescent↗
PubMed1983

[Prostaglandins A1, E1 and F2 alpha concentrations in the arterial and coronary venous blood of patients with ischemic heart disease during induced myocardial ischemia].

Prostaglandins (PGA1, PGE1 and PGF2 alpha) were assayed in 15 patients with chronic coronary disease during an anginal attack induced through frequent atrial stimulation. Measurements from eleven patients with intact coronary arteries served as control. Lactate extraction coefficient was used as a biochemical indicator of myocardial ischemia; the latter was associated with increased production of coronary sinus PGF2 alpha and arterial PGA1. No correlation could be established between PG levels in the studied series, the extent of ST depression on electrocardiograms, lactate extraction level and hemodynamic manifestations.

Alprostadil↗
PubMed1983

[Use of peripheral vasodilators and beta-adrenergic blockaders in the acute period of myocardial infarction (hemodynamic and metabolic aspects)].

The paper reports hemodynamic and biochemical findings in 76 patients with acute myocardial infarction on the basis of which the patients were treated with either peripheral vasodilators (sodium nitroprusside) or beta-blockers (obsidan). Changes in hemodynamic patterns and myocardial metabolism in response to treatment are described. It is concluded that careful hemodynamic and metabolic monitoring is essential in the management of acute myocardial infarction, particularly, where agents affecting the spread of necrotic areas are administered.

Adult↗