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N Salame

Publications and source records attributed to N Salame.

5 recordsLinked to original sources
PubMed2001

Cancer transmission through corneal transplantation.

PURPOSE: A retrospective study to demonstrate the safety of corneas from donors affected by systemic malignancies in a view of keratoplasty. METHODS: Using the data of the cancer registry department in a district of 500,000 residents, we analyzed retrospectively 143 patients followed up in the same region and transplanted between 1987 and 1995. We compared the incidence of cancer in recipients of cornea coming from donors with malignancies with recipients of cornea from donors without malignancies. The rate of cancer in this population was also compared with the incidence of cancer in the general population at the same age. RESULTS: Eleven patients (7%) were excluded from the study, eight of them for the presence of cancer in their medical history before surgery and the three others because of lack of information about their follow-up after surgery. Forty patients received corneas from cancerous donors and 103 from donors without cancer. Six patients developed malignancies between 1 and 4 years after transplantation, and only one of them received a cornea from a donor with a systemic malignancy. This recipient developed a different type of cancer from that of the donor. The five other patients received corneas from donors without systemic malignancies. By comparing theses results, there was no relationship between the occurrence of malignancies and transplantation of corneas from cancerous donors (relative risk = 0.49, 95% confidence interval = 0.01-13.62). CONCLUSION: There was no increased incidence of cancer in our patient population compared with reference population. Based on this study, there is no statistical or clinical evidence to suggest the transmission of cancer from donors with malignancies via corneal transplantation, according to the accepted criteria of donor selection.

Cornea↗
PubMed2000

[Procurement of corneas: analysis of inventory of hospital coordination. Prospective study at the Besançon Hospital University during the course of one year].

PURPOSE: To identify the obstacles contributing to the deficiency in supply of corneal donation. Quantitative and qualitative analysis of the collection and the distribution of corneas was performed by the staff of organ and tissue transplantation in the University Hospital of Besançon. METHODS: Medical records of all the deceased patients between the 8(th) of February 1998 and 28(th) of February 1999 were reviewed. In these medical records, we distinguished 2 groups RESULTS: During the study period, 1044 patients died at Besançon University Hospital. 616 medical records were checked and 428 were not. Out of 616 checked medical records, we found 337 (54%) medical contraindications, 112 (18%) denied requests, 105 (17%) logistic problems and 62 (10%) procurements after consent. Out of 428 medical records unchecked, we found 215 (50%) medical contraindications, 199 (46%) potential donors and 14 (3,2%) logistic problems. The most important factor of non cornea procurement was medical contraindication. The unavailability of the transplant coordination ophthalmologists and logistic problems represented 30% of non procurement corneas. Relatives opposition was found only in 18% of cases. CONCLUSION: This survey was an overview of the real condition of corneal donation in our institution. Caution regarding medical selecting donor corneal material should be used even if it represents the most important factor of non cornea procurement. To increase the supply of donor material, logistic and audibility of transplant coordination and surgeons should be improved.

Cornea↗
PubMed1997

[Intrathoracic retrotracheal goiter: excision through a cervical approach].

A case of retrotracheal goiter in the posterior mediastinum in a 53 year-old woman revealed by dyspnea is here described. A computed tomographic scan and magnetic resonance imaging specified the his extension from the lower flap of the thyroid, and its relationships in the mediastinum. It was removed through a cervicotomy only.

Female↗
PubMed1979

[Use of the computer in teaching rheumatology. Trial application in the diagnosis of an adult polyarthritis].

The immense possibilities offered by the computer can be utilized in medical education, through a free dialogue between the student and the machine thanks to a terminal. A diagnostic simulation program has been carried out in diagnosing adult polyarthritis. This program neccesitates an analysis of diagnostic behavior and, on this basis, the preparing of a diagnostic tree or graph. The reasons leading to the plan adopted in constructing the graph, are discussed. Cases of increasing difficulty are proposed to the student, who must follow the course plan in order to arrive at a diagnosis. This teaching method, applied for thing pedagogical advantages both for the teacher and the student. The operating cost seems reasonable.

Adult↗