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Biomedical subjects

N Samuels

Publications and source records attributed to N Samuels.

8 recordsLinked to original sources
PubMed2000

Chronotherapy in traditional Chinese medicine.

The circadian rhythm of illness has been emphasized for thousands of years in Traditional Chinese Medicine (TCM), using this knowledge to schedule therapies such as acupuncture during appropriate hours of the day. This paper reviews the time periods (two hour segments) that apply to each organ system according to TCM (lungs, large intestine, stomach, heart, kidneys and liver), and elaborates on how recent medical research has found similar relevant biorhythms in these very same organ systems.

Chronotherapy↗
PubMed2000

Attitudes towards anti-smoking legislation in Israel: a Jerusalem study.

BACKGROUND: With smoking on the rise among teenagers, the United States has recently implemented anti-smoking legislation, though with questionable success. OBJECTIVES: To examine the attitudes in Israel to such legislation. METHODS: An interviewer-administered questionnaire was completed by 505 adults: 217 undergoing general employment checkups and 288 amateur athletes requiring medical testing for certification. Smoking habits and attitudes toward anti-smoking legislation were examined. RESULTS: The overall rate of smoking was 25.3%, with a male:female ratio of 1:24 (P = 0.232). Most smokers (65.6%) started smoking before the age of 20, and only 47.7% tried to quit at least once. Both the smokers and the non-smokers who were interviewed were in favor of legislation that recognized cigarettes as an addictive substance, restricted the sale of cigarettes to people aged 18 and older, and banned cigarette advertisements. CONCLUSIONS: Anti-smoking legislation is looked upon favorably by Israelis, though the true benefit of such measures is questionable. Priority must be given to primary prevention through education and empowering youth to choose not to smoke.

Adult↗
PubMed1999

Pulmonary hypertension secondary to neurofibromatosis: intimal fibrosis versus thromboembolism.

Neurofibromatosis has been known to involve blood vessels throughout the body. Pulmonary involvement with interstitial fibrosing alveolitis has been described but no case of pulmonary vascular involvement has been reported to date. A 51 year old patient with cutaneous neurofibromatosis is described who presented with severe pulmonary hypertension and radiographic, scintigraphic, and angiographic evidence of chronic thromboembolic pulmonary hypertension. Severe intimal fibrosis consistent with vascular involvement with neurofibromatosis was found on endarterectomy with no evidence of pulmonary thromboembolism. Neurofibromatosis of pulmonary arteries should be considered as a possible cause of pulmonary hypertension.

Angiography↗
PubMed1997

Smoking among hospital doctors in Israel and their attitudes regarding anti-smoking legislation.

Anti-smoking legislation has been implemented in several countries. In order to study the attitudes of Israeli doctors to such legislation, 260 hospital doctors were questioned regarding their smoking habits and attitudes towards anti-smoking legislation. It was discovered that 15.8% are current smokers [40% of radiologists, 25% of surgeons and anesthetists, and 8% of internists and pediatricians (P = 0.0005)], of which 76% began smoking before the age of 20, and 54% tried to quit at least once. 24.2% of the current non-smokers are prior smokers who stopped, 92% of non-smokers and 83% of smokers tell their patients to quit (P = 0.10). 69% feel that cigarette sales should be limited to those of 18 y and older, 77% that advertisements for cigarettes should be prohibited, and 74% that nicotine should be recognized as an addictive substance. Doctors who smoke may have difficulty promoting healthy behavior among their patients. They must be offered help in order to quit, and emphasis should be placed on prevention among medical students.

Adult↗
PubMed1996

Polyarteritis nodosa and drug abuse: is there a connection?

Drug abuse has been controversially linked to polyarteritis nodosa. A 28-year-old man with a history of drug abuse with inhaled heroin presented with an enigmatic illness consisting of refractory fever, bilateral pleural effusions, migratory polyarthritis, and a leukaemoid reaction. An abdominal angiography confirmed the diagnosis of polyarteritis nodosa, and treatment with both prednisone and cyclophosphamide resulted in significant clinical and laboratory improvement.

Adult↗
PubMed1994

Sepsis stimulates nonlysosomal, energy-dependent proteolysis and increases ubiquitin mRNA levels in rat skeletal muscle.

We tested the role of different intracellular proteolytic pathways in sepsis-induced muscle proteolysis. Sepsis was induced in rats by cecal ligation and puncture; controls were sham operated. Total and myofibrillar proteolysis was determined in incubated extensor digitorum longus muscles as release of tyrosine and 3-methylhistidine, respectively. Lysosomal proteolysis was assessed by using the lysosomotropic agents NH4Cl, chloroquine, leupeptin, and methylamine. Ca(2+)-dependent proteolysis was determined in the absence or presence of Ca2+ or by blocking the Ca(2+)-dependent proteases calpain I and II. Energy-dependent proteolysis was determined in muscles depleted of ATP by 2-deoxyglucose and 2.4-dinitrophenol. Muscle ubiquitin mRNA and the concentrations of free and conjugated ubiquitin were determined by Northern and Western blots, respectively, to assess the role of the ATP-ubiquitin-dependent proteolytic pathway. Total and myofibrillar protein breakdown was increased during sepsis by 50 and 440%, respectively. Lysosomal and Ca(2+)-dependent proteolysis was similar in control and septic rats. In contrast, energy-dependent total and myofibrillar protein breakdown was increased by 172% and more than fourfold, respectively, in septic muscle. Ubiquitin mRNA was increased severalfold in septic muscle. The results suggest that the increase in muscle proteolysis during sepsis is due to an increase in nonlysosomal energy-dependent protein breakdown, which may involve the ubiquitin system.

Animals↗