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Biomedical subjects

N Santangelo

Publications and source records attributed to N Santangelo.

3 recordsLinked to original sources

Spontaneous motor activity in normal fetuses.

AIM: The aim of this work was to perform a quantitative analysis of the different activities (mouth, eye and gross body movements) in the fetuses of 15 women with normally evolving pregnancies, and also to show the existence of intrauterine neurological maturation. METHODS: At 28, 34 and 38 weeks of gestation, 15 fetuses underwent a 60-min ultrasound observation. The data from the activities observed allowed the calculation, for each patient and each type of activity, of incidence, duration and intervals; relation between these and of each fetal activity for each gestational period; and the correlation between the different findings. RESULTS: The analysis of the data showed only a significant decrease in the incidence of gross body movements and a significant increase in the incidence of mouthing movements between 28 and 38 weeks of gestation. A correlation analysis failed to show any significant correlation between the various activities at 28 weeks, but found a positive correlation between eye, gross body movements and "other mouth movements," and a negative correlation between mouthing activity and the other activities examined at 34 and 38 weeks of gestation. CONCLUSION: The authors conclude that there is a trend of fetal activities, which is an expression of fetal neurological maturation.

Adult↗

Repair of extensive ionizing-radiation DNA damage at 95 degrees C in the hyperthermophilic archaeon Pyrococcus furiosus.

We investigated the capacity of the hyperthermophile Pyrococcus furiosus for DNA repair by measuring survival at high levels of 60Co gamma-irradiation. The P. furiosus 2-Mb chromosome was fragmented into pieces ranging from 500 kb to shorter than 30 kb at a dose of 2,500 Gy and was fully restored upon incubation at 95 degrees C. We suggest that recombination repair could be an extremely active repair mechanism in P. furiosus and that it might be an important determinant of survival of hyperthermophiles at high temperatures.

Archaea↗

Danazol induced cholestasis: pathogenetic hypothesis.

Numerous mechanisms have been proposed to account for deficient bilirubin excretion and the pathogenesis of estrogen and steroid (danazol) induced intrahepatic cholestasis. Our hypothesis is based on the fact that danazol is administered in the treatment of pulmonary emphysema because it stimulates synthesis of alpha-1 antitrypsin and that other estrogen glucuro-conjugated metabolites are P-glycoprotein substrates. We believe that genetic alterations of alpha-1 antitrypsin and P-glycoprotein, either alone or in association with known pathogenetic mechanisms, may explain the onset of danazol induced cholestasis and justify the difference in its varying duration and intensity.

Cholestasis, Intrahepatic↗