Pharmacodynamic action of natural food.
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Biomedical subjects
Publications and source records attributed to N Sapeika.
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Examples are given of interactions between foods and drugs, some of which may on occasion produce adverse effects. Such interactions are not as frequent and rarely as significant as interactions between drugs, which have become of increasing interest and importance.
Mefenamic acid, and to a lesser extent, flufenamic acid have a significant inhibitory effect on lipolysis as determined by the action of mouse pancreas lipase on the dilauric (didodecanoic) acid ester of fluorescein. Ibuprofen, fenoprofen calcium, phenylbutazone, oxyphenbutazone and alclofenac had comparatively little effect.
The tyramine content of certain South African cheeses has been determined by gas chromatographic analysis. Aged (mature) cheese such as cheddar and Roquefort contain relatively large concentrations of tyramine as compared with other cheese, especially cottage cheese. Foods containing pressor amines must be avoided by certain patients.
Sodium valproate is an anticonvulsant which, unlike phenobarbitone, does not produce an increase in rat hepatic P450 when given in large nontherapeutic doses.
Chlorphentermine, fenfluramine and dexamphetamine have a pronounced stimulating effect on lipolysis as determined by the action of mouse pancreas lipase on the dilauric (didodecanoic) acid ester of fluorescein. Diethylpropion and phendimetrazine have a comparatively minor effect.
Phenformin and metformin have a stimulating effect on lipolysis as determined by the action of mouse pancreas lipase on the dilauric (dido-decanoic) acid ester of fluorescein. Tolbutamide and chlorpropamide have an inhibitory effect.
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Propylhexedrine and chlorphentermine inhibit the activity of NADH cytochrome c reductase but to a lesser extent than fenfluramine. Diethylpropion and phendimetrazine have little effect.
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