Humane endpoints and acute toxicity testing.
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Animal Testing Alternatives↗
Biomedical subjects
N Sass
Publications and source records attributed to N Sass.
Light microscopic observations on the reproductive tract of the male sand rat, Psammomys obesus.
The anatomy of the reproductive tract of the male sand rat, Psammomys obesus, was examined by light microscopy. Histologically, the reproductive tract is similar to other rodent species. Seminiferous tubules in the 1-month-old sand rat do not contain a tubular lumen but Sertoli cells, spermatogonia and spermatocytes are present. A full complement of germ cells is present in the seminiferous tubules by 2.5 months and spermatogenesis is well established. The interstitial space is not well defined until 2.5 months when cell types typical of most rodent species are observed. The epididymis is not noticeably segmented into lobules. An epididymal lumen is not observed until 2.5 months. Cauda epididymal sperm are not observed in the 1 or 2.5-month-old animals and cauda epididymal sperm counts from the 7.5 and 12.5-month-old animals are highly variable. The epididymis, proximal and middle regions of the vas deferens, seminal vesicles and prostate display morphological and histological characteristics similar to other rodent species. The distal end of the vas deferens is not expanded to form an ampulla.
Animals↗
[Prenatal corticoid therapy in hypertensive syndromes of pregnancies and its effects in maternal blood pressure].
PURPOSE: To evaluate the behaviour of blood pressure among hypertensive pregnants during glucocorticoid therapy (LIGGINS scheme) in order to accelerate the maturity of fetal lung. METHODS: In a retrospective study, 27 pregnant with a story of hypertensive disorder, between 24 and 34 weeks, during glucocorticoid cycle were avaluated. For this matter, statistical analisis were performed using the means of systolic (SBP) and diastolic blood pressure during the therapy days, on the day before and on the day after. The results were statistically analyzed with F statistic test ( significant if p<005) RESULTS: There was no statistical variance in blood pressure levels, neither in SBP nor in DBP. There was no difficulty in clinical controls and no change in antihypertensive drugs related to glucocorticoid therapy. CONCLUSIONS: Our results show observe the safety of glucocorticoid therapy among pregnant women with hypertensive disorders related to the possible raising of the blood pressure levels.
Adrenal Cortex Hormones↗
Haff disease: from the Baltic Sea to the U.S. shore.
Haff disease, identified in Europe in 1924, is unexplained rhabdomyolysis in a person who ate fish in the 24 hours before onset of illness. We describe a series of six U.S. patients from 1997 and report new epidemiologic and etiologic aspects. Although Haff disease is traditionally an epidemic foodborne illness, these six cases occurred in two clusters and as one sporadic case.
Adult↗
[Study of pregnancy with chronic hypertension].
This is a retrospective study of 189 chronic hypertension patients seen at the Discipline of Obstetrics of the São Paulo Medical School at Hospital São Paulo. The data were fed into a computer and several selected variables and established interrelations were run to have a statistical study by means of non-parametric tests. Hypotheses were rejected at a level of 5.0 percent. Results allow to conclude that there is an association of obesity and chronic hypertensive women to obstetrical occurrences such as delayed intra-uterus growth and pregnancy-specific hypertensive disease. With respect to development during pregnancy, a higher number of newborn mortality was observed and correlated to metabolic disorders, infectious diseases, and problems of the respiratory system. However, the authors did not see a high incidence of congenital malformation. All such results lead to the conclusion that the incidence of fetus death, neonatal mortality, and perinatal mortality are five times more frequent in this group than in the control group.
Adult↗