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Biomedical subjects

N Saxe

Publications and source records attributed to N Saxe.

At least 37 records · Page 2Linked to original sources
PubMed1986

Patterns of dermatology referrals in a general hospital.

A survey of 500 patients hospitalized in non-dermatology wards and referred for dermatological opinion is reported. In approximately 50%, the skin lesions were related to the presenting illness; in 36.6% of these patients the skin condition contributed substantially to the diagnosis of the systemic disease. This study emphasizes the considerable interface between cutaneous and systemic disease and the need for close co-operation between medical and dermatology departments. The implications for postgraduate education are highlighted, since such patients are infrequently seen in a dermatology out-patient setting.

Aged↗
PubMed1986

Scleredema in an infant.

A 3-month-old infant with scleredema had associated cytomegalovirus pneumonia with a rapidly fatal course. Because differentiation of scleredema from scleredema neonatorum, subcutaneous fat necrosis, and scleroderma may be difficult, histologic diagnosis is important. Cetylpyridinium chloride was used successfully as a fixative to demonstrate acid mucopolysaccharides histologically.

Biopsy↗
PubMed1984

Pseudoxanthoma elasticum in South Africa--genetic and clinical implications.

After investigation by a multidisciplinary team, 19 cases of biopsy-proven pseudoxanthoma elasticum are described. Evidence for an increased gene frequency in the Afrikaner population was found, as was support for the claim of genetic heterogeneity in the disorder. The well-described clinical manifestations involving the eyes, skin and cardiovascular system were seen, as were more rarely reported features such as acne, telangiectasia of the lips and bilateral cataracts. Mitral valve prolapse and gastro-intestinal haemorrhage were not found in our patients, although there are several reports in the literature.

Adolescent↗
PubMed1984

Dyskeratosis congenita. Haematologic, cytogenetic, and dermatologic studies.

In a family of 5 boys and 6 girls, 3 brothers have clinical dyskeratosis congenita. Teeth from 2 of the patients were taurodent , and mineral density of the enamel was significantly different from normal. The haematopoietic marrow was hypocellular and there was striking prominence of plasma cells having normal morphology; no granulomata were demonstrated. The decreased erythroid precursors in the marrow correlated with quantitatively reduced erythropoiesis demonstrated on ferrokinetic studies. Recurrent infections occurred but could not be related to neutropenia, and granulocytes and monocytes retained normal function. No abnormality was demonstrated in humoral or cellular immune mechanisms. While superficially similar, dyskeratosis congenita and Fanconi's anaemia are genetically distinct, being X-linked in the former and inherited as an autosomal recessive in the latter.

Adolescent↗
PubMed1980

Mucocutaneous lymph node syndrome in a young adult. A case report.

The mucocutaneous lymph node syndrome, first noted in 1961 by Kawasaki in Japan, is an acute, febrile mucocutaneous condition accompanied by cervical lymphadenopathy, which affects infants and young children. More recently it has been recognized in other countries, but not before 1979 in South Africa.

Adolescent↗
PubMed1979

Women doctors wasted.

The problem of wastage of women doctors has exercised the minds of South African medical planners very little. Numerous articles have appeared in the English literature, but we have been able to find only two editorials in semi-facetious vein in the South African Medical Journal over the last 20 years. We have looked at some trends, and believe that there is a need for further investigation, because there are important implications concerning future medical manpower resources in this country.

Education, Continuing↗
PubMed1978

Acute febrile neutrophilic dermatosis (Sweet's syndrome). Four case reports.

Four patients with unusual features of acute febrile neutrophilic dermatosis (Sweet's syndrome) are reported. This syndrome is more common than is apparent from the small number of case reports. It has well-defined clinical and histological criteria, but may be considered within the erythema multiforme spectrum of reaction patterns. The clinical presentation and course can vary, as illustrated by these 4 case reports.

Acute Disease↗
PubMed1978

Dermatofibrosarcoma protuberans with lymph node and pulmonary metastases.

Dermatofibrosarcoma protuberans is a locally aggressive histiocytic tumor that, on rare occasions, may metastasize to regional lymph nodes or even to distant sites. We report a dermatofibrosarcoma protuberans with lymph node involvement in a 27-year-old woman. This tumor recurred repeatedly after local excisions, and ten years after the first resection, widespread pulmonary metastases developed in the patient and she died four years later. More than 400 patients with dermatofibrosarcoma protuberans have been reported in the literature; including the present case, five of these patients had lymph node metastases, 17 patients had hematogenous spread, and three had both lymphatic and blood-borne metastases.

Adult↗
PubMed1977

Angiolymphoid hyperplasia with eosinophilia: report of 3 cases.

Angiolymphoid hyperplasia with eosinophilia is reported in 3 patients. This lesion is an uncommon reactive vasoproliferative disorder which presents with swellings in the dermis and subcutis. The aetiological agent which produces this tissue response is unknown. Clinically the disease follows a benign prolonged course without evidence of systemic involvement. The histological features consist of a prominent fibroblastic and proliferative vascular reaction associated with an inflammatory infiltrate in which lymphoid aggregates with germinal centres and eosinophils are conspicuous.

Adult↗
PubMed1977

Lymphoma of the skin. A comparative clinico-pathologic study of 50 cases including mycosis fungoides and primary and secondary cutaneous lymphoma.

A clinico-pathologic study of lymphomas of the skin included 14 cases of mycosis fungoides, 14 of primary lymphoma and 22 of secondary lymphoma. Mycosis fungoides has clinical and histopathologic features which allow for separation from the other groups. In this study, patients with mycosis fungoides had a longer duration of history and presented with papules, plaques, erythroderma or generalized dermatitis but not with tumor nodules ab initio. A confident histologic diagnosis required the presence of the mycosis cell, which was usually present in association with a mixed inflammatory cell infiltrate. Another important histologic feature was the presence of invasion of the epidermis by the mycosis cells singly and/or in nests (Pautrier microabscesses). Primary and secondary lymphomas of the skin presented clinically as multiple tumor nodules and histologically as a monomorphic infiltrate of neoplastic cells confined to the dermis and subcutis. A feature which has not been adequately documented in a large series was the presence of an associated prominent epithelioid cell reaction in several cases from all three groups.

Female↗
PubMed1977

Epithelioid sarcoma. A distinctive clinical presentation.

A case of epithelioid sarcoma occurred in an adult black man. The neoplasm recurred after 15 years in the form of multiple nodules and distinctive annular plaques. To our knowledge, this latter clinical manifestation has not been reported previously.

Adult↗
PubMed1976

Subepidermal bullous disease. A correlated clinico-pathologic study of 51 cases.

The histologic features of 51 cases of subepidermal bullous disease were evaluated and correlated with the clinical features including the course of the disease and the response to therapy. There was a good clinico-pathologic correlation, 46 out of 51 cases showing concordant clinical and histologic diagnoses. We conclude that although immunofluorescence is a confirmatory procedure histologic diagnosis is still of great value, particularly in the early stages of the disease when the clinical features may not yet have evolved sufficiently to allow for a confident diagnosis.

Child↗
PubMedDate not supplied

Tinea capitis in adults.

Tinea capitis is regarded as rare in healthy adults. A study of 46 adults presenting with scalp problems with no other identifiable cause and 26 asymptomatic adult contacts of children with tinea capitis was undertaken. The confirmation of tinea capitis in 9 of 46 patients and 5 carriers among 26 adult contacts suggests that tinea capitis may affect healthy adults more often than was supposed. Further epidemiologic studies may be of interest.

Adult↗