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Biomedical subjects

N Schnaper

Publications and source records attributed to N Schnaper.

14 recordsLinked to original sources
PubMed1985

Training and oncologists' changing attitudes toward their own cancer therapy.

Oncologists' attitudes toward therapy for his or her own hypothetical cancer have not been studied, and they may influence therapeutic decisions for patients. This study compared attitudes of oncologists at different levels of training toward therapy for their own hypothetical cancer. Those with limited oncology experience had high expectations for treatment, as expressed in their acceptance of all therapeutic modalities for their own disease. Early intensive inpatient oncology experience (first year of training) led to disenchantment, and rejection of various therapies. Further outpatient experience led to an increased acceptance of therapy again, and those finishing second and third year of oncology training, and senior medical staff in oncology, had high expectations for treatment. These results suggest an evolution of attitudes toward therapy with training and experience.

Attitude of Health Personnel↗
PubMed1976

Overview: psychiatric sequelae to multiple trauma.

The authors discuss the setting, patients, and staff, and the role of psychiatric consultants in intensive care units and trauma centers. They point out the similarities and differences between patients with multiple trauma and those who have had open-heart surgery and head or spinal cord injuries. They also deal with the question of an element of self-destructive behavior in accidents and offer suggestions for the psychiatric management of severely traumatized patients. The authors conclude that the role and obligation of the psychiatrist of the the future will lie in crisis intervention within the medical-biological model.

Accident Proneness↗
PubMedDate not supplied

Initial observations on the effects of delta 9-tetrahydrocannabinol on the plasma pharmacokinetics of cyclophosphamide and doxorubicin.

We studied the effect of THC upon the pharmacokinetics of cyclophosphamide (CTX) and doxorubicin (ADR). Plasma THC was determined by RIA. Plasma concentrations of CTX and ADR were measured by GLC and fluorescence, respectively. RIA confirmed plasma levels of THC greater than 20 ng/ml for patients who received THC. CTX half-life was not significantly changed with use of THC (7.7 +/- 3.6 hours without versus 5.25 +/- 2.6 hours with THC). ADR half-life with THC was greater than without THC (175 +/- 197 hours versus 92 +/- 92 hours, respectively). Total drug exposure as determined by areas under the curves were similar (12.4 +/- 6 microM . hr without versus 13.8 +/- 4 microM . hr with THC). These preliminary data suggest that RIA is reliable for assessing THC plasma concentrations. THC induces no apparent alterations of CTX or ADR pharmacokinetics.

Cyclophosphamide↗