Biomedical subjects
Publications and source records attributed to N Sera.
The rec-assay of the nitropyrenes in Bacillus subtilis was performed. All nitropyrene derivatives were positive in this system. Especially, 3 isomers of 1,3-, 1,6- and 1,8-dinitropyrene and 4-nitropyrene were found to possess strong DNA-damaging capacities at extremely low concentrations.
Clinical effect of acetylspiramycin, one of macrolide antibiotics, primary atypical pneumonia and serologically proven Mycoplasma pneumonia in children was studied. Twenty-four cases of these pneumonia (PAP 11, MP 13) in children were selected and acetylspiramycin was given in dose of approximately 30 mg/kg/day orally. Clinical response was evaluated in terms of improvement in fever, cough and chest X-ray. Clinical response was excellent in 4, good in 5, fair in 14 cases and none in 1 case. No definite adverse effect was observed, however 3 cases showed skin rashes. Two cases showed evanescent small erythematopapulous rash and 1 case developed urticaria on the 2nd to 4th day after this drug was given. These skin rash seemed one of the manifestation of Mycoplasma infections, rather than adverse side effect. One case showed elevated transaminase activity before acetylspiramycin was given and improved on the 2nd week, although this drug was continued. No other side effect was observed. We were able to use acetylspiramycin only in the form of 200 mg tablet and difficulty of the administration was encountered in children under 5 years of age. Other form (dry syrup, etc.) of this drug should be considered for the clinical use in children. In conclusion, acetylspiramycin was effective and safe for the treatment of primary atypical pneumonia and Mycoplasma pneumonia.
Explore the source record for details and available documents.
The mutagenicity of SRM 1649 and 1650 was tested in the presence of rat liver S9 mix which was induced by polychlorinated biphenyl (PCB) or by the combination of phenobarbital and 5,6-benzoflavone. The S9 mix induced by PCB activated benzo[a]pyrene strongly. The S9 mix induced by phenobarbital-5,6-benzoflavone activated the complex mixtures to approximately the same extent as that induced by PCB. This finding indicates that phenobarbital-5,6-benzoflavone instead of PCB may be suitable as an inducer under some conditions. The preincubation procedure for the mutagenicity test was performed by preincubating the test compound, S9 mix and bacteria for 20 min in a water bath. This procedure was as effective as the plate incorporation test.
Explore the source record for details and available documents.