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N Sh Amirov

Publications and source records attributed to N Sh Amirov.

At least 19 recordsLinked to original sources
PubMed1995

[The hormonal characteristics of the pathogenesis of gastric peptic ulcer and duodenal peptic ulcer].

Blood levels of STH, ACTH, somatostatin, bombesin, gastrin, hydrocortisone, aldosterone, testosterone, estradiol, progesterone and gastric juice levels of gastrin and somatostatin were measured in remission and exacerbation of gastric and duodenal ulcer (GU), (DU) using radioimmunoassay. The study included 250 DU, 200 GU and 5O control subjects. As a result, two forms of DU were identified. DU type 1 is characterized by basal and stimulated hypergastrinemia, paradoxical D-cell response to stimulation, high blood concentrations of STH, ACTH, testosterone. Type 2 DU exhibits basal hypogastrinemia, elevated gastrin concentration in response to stimulation, adequate reaction of D-cells, low levels of estradiol and progesterone. In GU there were low concentrations of STH, bombesin, hydrocortisone, estradiol, testosterone, progesterone, somatostatin. D-cell response to loading was adequate. It is concluded that DU and GU pathogeneses are different, that DU is a heterogeneous disease.

Adolescent↗
PubMed1994

[Enzymologic factors in the development of ulcerative process in gastroduodenal mucosa].

The contribution of gastric proteolytic enzymes to formation of an ulcerated defect in the mucosa of the stomach and duodenum was studied in the experimental and clinical settings. There is no evidence for involvement of gastric secretory proteinases (pepsins) in ulceration in early periods. The secretory enzymes are likely to participate in maintaining the existing ulcers, preventing their healing. In patients with ulcerative disease and in animals with experimental ulcers, gastric juice is more aggressive against the mucosa than that of healthy human beings and animals. A possible role of carbohydrate components of gastric juice in the regulation of the "aggression" of gastric enzymes, as well as that of lysosomal enzymes in ulceration, namely the forming role of the latter during early ulceration are considered in the paper.

Animals↗
PubMed1993

[Aggressive role of lysosomal enzymes in gastric ulceration].

Administration of lysosomes and lysosome enzymes into the submucous base of intact rats' stomachs did not result in ulceration. Premedication by histamine, serotonin (combined and separated) and ACTH did not increase sensibility of mucous membrane to lysosome enzymes. Prednisolone-premedication provoked the decrease of mucous membrane resistance to free lysosome enzymes and appearance of ulcerative lesions in the point of enzyme applications. Free lysosome enzymes are able to produce ulcerative lesions. This process is going on with the participation of prednisolone.

Adrenocorticotropic Hormone↗
PubMed1992

[The role of lysosomal enzymes in the formation of destructive processes in the gastroduodenal area].

The paper reviews works by the author and his colleagues on the problem of pathogenesis of ulcer formation within the gastroduodenal area. The stomach enzymes active in weakly acid pH zone 4.0-7.0, were shown to play a major part in the mechanisms of ulcer formation. These enzymes are of lysosomal origin and the ulcer formation starts within the mucous-submucous layer's tissues. Destabilizing of the lysosomes and release of autoaggressive lysosomal enzymes occurs under the effect of excessive production of the biogenic amines histamine and serotonin. Adrenal hormones are also involved in the process of ulcer formation.

Animals↗
PubMed1992

[The content of gastrin, bombesin and somatostatin in the blood and gastric juice of patients with duodenal and gastric peptic ulcer].

Ninety patients suffering from peptic ulcer and 25 healthy subjects were examined for the content of gastrin, bombesin and somatostatin in blood and gastric juice. Among patients with duodenal ulcer, 2 groups were distinguished: group I included patients in whom peptic ulcer occurred before 30 years; the majority of the patients manifested blood hypergastrinemia, a decrease of bombesin concentration and normal somatostatin concentration; gastric juice was characterized by a lowering of somatostatin concentration and unchanged gastrin concentration; group II was made up of patients who developed peptic ulcer after 30: in the majority of the patients, gastrin concentration was reduced under basal conditions, after loading it was unchanged; in part of the patients, blood somatostatin concentration was elevated, in 16 in exacerbation and in 19 in remission; in the remainder, it was unchanged. The concentration of bombesin in blood remained unchanged. In gastric juice, gastrin concentration was increased only after histamine administration, somatostatin concentration was unchanged whatever the disease stage. In patients with gastric ulcer, gastrin concentration in blood was elevated only under basal conditions, being unchanged in gastric juice irrespective of the disease stage. Meanwhile, the concentration of bombesin was lowered both under basal conditions and after insulin administration, the concentration of somatostatin was decreased both in blood and gastric juice whatever the disease stage.

Adult↗
PubMed1991

[A rapid radionuclide method for clinical assessment of gastric juice proteolytic activity and acidity].

A new method for radionuclide measurement of gastric juice proteolytic activity (GJPA) is described. GJPA is determined according to the time of dissolution of the protein capsule filled with 99mTc-pertechnetate solution. In vitro experiments made with 342 samples of gastric juice revealed a correlation (p1 less than 0.01) between the time of dissolution of the 99mTc-pertechnetate capsule and proteolytic activity measured according to Metta's method. No correlation was established between GJPA (measured by Metta's method and by radionuclide method) and gastric juice acidity (p greater than 0.05). In 63 patients examined, the time of capsule dissolution was 15 to 18 minutes with GJPA being normal, 8 to 14 minutes (p less than 0.01) with elevated parameters of GJPA, and 19 to 37 minutes (p less than 0.01) with GJPA being reduced. The given method is a physiological one, sufficiently precise and can be recommended for a screening analysis of GJPA.

Adolescent↗
PubMed1990

[Peptic ulcer].

Explore the source record for details and available documents.

Campylobacter↗
PubMed1988

[Changes in the cyclic nucleotide level and lysosomal enzyme activity in the gastric mucosa of rats with experimental ulcer formation].

The experiments on rats have proved that ulcerative lesions in the gastric mucosa influenced by intraperitoneal catecholamines (noradrenaline and adrenaline) develop on the background of pronounced decrease of cAMP level in the gastric mucosa during ulceration and relatively slight fluctuations of cGMP level. As a result, cAMP/cGMP ratio in mucosa was significantly decreased during ulceration. These changes in cAMP level and cAMP/cGMP ratio may play an important role in destabilization of lysosomal membranes followed by a chain of pathological reactions resulting in ulcerative lesions of the gastric mucosa.

Animals↗
PubMed1988

[Secretion of cortisol and growth hormone in patients with peptic ulcers of the stomach and the duodenal bulb].

A total of 42 patients with gastric ulcer and ulcer of the duodenal bulb were investigated. A decrease in the blood concentration of STH and cortisol, high indices of gastric acidifying function in the 2nd hour after insulin administration were noted in the patients with gastric ulcer indicating a decrease in the trophic influence of the hormones of the hypophysis-adrenal system on the GI tract, on the one hand, and raised sensitivity of parietal cells to the effects of this system, on the other hand. In the patients with duodenal ulcer the blood levels of STH and cortisol did not change, indices of gastric acidifying function within the 1st hour after insulin administration were higher than during the 2nd hour indicating an important role of the vagus nerve hypertonicity in the pathogenesis of this disease.

Adult↗
PubMed1987

[Lysosomal enzyme activity of the gastric mucosa in rats during experimental ulcer formation].

Lysosomal membrane stability has been studied in the gastric mucosa in response to mechanical damage caused by lysosomal fractionation and release of lysosomal enzymes from mucous cells into the gastric cavity of alive animals during induction of acetic ulcer or erosive damage of the gastric mucosa resulting from intraperitoneal introduction of histamine and serotonin. It has been found that all types of ulcerogenesis in the gastric mucosa led to the decrease in lysosomal membrane stability to mechanical stress in the course of lysosomal fractionation. In addition there was a substantial release of lysosomal enzymes into the gastric cavity in different types of ulcerogenesis. The decrease in lysosomal membrane stability combined with a subsequent development of ulcers and erosions in the gastric mucosa seems indicative of the fact that lysosomal enzymes take part in the initial formation of ulcers in the gastric mucosa.

Acetates↗
PubMed1983

[Proteolytic enzymes of the gastric mucosa in the dog].

12 proteolytic fractions were obtained with disc--electrophoresis from the gastric mucosa in healthy dogs. 5 proteases (I group) were only found in fundus and gastric body whereas 7 those (II group) were found in antrum as well. Study of the fractions proteolytic activity revealed two of them to be active in pH 1.0-5.0; two in pH 4.0-5.0; one in pH 1.0-2.0; the area of other proteases activity involved 3-4 units of pH. The considerable amount of proteases and the large area of their activity seem to secure the protein hydrolysis in the stomach in different pH values of eaten food.

Animals↗
PubMed1982

[Changes of acid phosphatase in the gastric mucosa during ulcerogenesis].

Experiments were performed on white rats with experimental acetate ulcer of the stomach and intestine. At the height of destruction of gastric mucosa tissue (60 minutes from the onset of ulcer formation) a consistent increase in acid phosphatase secretion was recorded. This process was accompanied, as a rule, by significant elevation of proteolytic activity (pH 6.5-7.0) in tissue extract obtained from the affected area. It is suggested that the increased proteolytic activity observed at pH 6.5-7.0 in the tissue extract from the ulcerous area is most likely related to the release of lysosomal proteases at the height of tissue destruction. It thus appears that ulcer of the gastric mucosa induced by acetic acid application is determined by interstitial proteolytic activity of cathepsins that are released during the destruction of lysosomal membranes.

Acid Phosphatase↗
PubMed1982

[Changes in the rat gastric mucosa after intragastric administration of gastric juice from healthy controls and from patients with duodenal ulcer].

It has been shown in rat experiments that gastric juice from duodenal ulcer patients possesses significantly greater aggressiveness as regards the gastric mucosa of rats as compared to gastric juice from normal subjects. Injuries to the gastric mucosa of rats under the experimental conditions were consequent, apart from the injuring action of exogenic proteases of the patients' gastric juice, on activation of the system of mucosal proteases active in a weak-acidic medium (lysosomal), as well as on the decreased resistance of rat gastric mucosa proteins to the destruction by rat gastric mucosa pepsins under acidic pH values. The impairment of the mucosal resistance to the destruction might be promoted by the reduced number of glycosaminoglycan fractions, detected during electrophoresis of the mucosal extracts from the experimental rats.

Animals↗