Thyroid function testing in dogs.
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Animals↗
Biomedical subjects
N Shoulberg
Publications and source records attributed to N Shoulberg.
Physiological antagonism caused by adrenergic stimulation of canine tracheal muscle.
We studied the simultaneous alpha- and beta-adrenergic response characteristics of canine tracheal smooth muscle in 398 strips from 67 dogs in vitro. Experiments were performed to determine the effects of beta-adrenergic blockade on the expression of the alpha-adrenoceptor contractile responses elicited by norepinephrine (NE), phenylephrine (PE), and clonidine (CLO). Maximal active tension caused by NE increased from 39.1 +/- 27.0 to 241 +/- 75.0 g/cm2 as the concentration of propranolol (PROP) was increased from 10(-6) to 10(-4) M. Augmentation of tracheal smooth muscle contraction caused by PE and CLO was also observed with progressive beta-adrenoceptor blockade; contraction to NE, PE, and CLO was blocked selectively with 3 X 10(-5) M phentolamine (PA) and phenoxybenzamine (PBZ). The beta-adrenergic relaxing properties of the same three agonists were also studied. After alpha-adrenergic blockade with PA or PBZ, all three agonists caused relaxation (NE greater than CLO greater than PE) of methacholine-induced contraction of tracheal smooth muscle that was reversed selectively with PROP. We demonstrate that NE, PE, and CLO cause simultaneous stimulation of both the alpha- and beta-adrenergic receptors in tracheal smooth muscle; the net response elicited is the result of adrenergic physiological antagonism and depends on the relative degree of alpha- and/or beta-adrenoceptor blockade.
Adrenergic alpha-Antagonists↗
The neuroethological approach to obsessive-compulsive disorder.
Advances in the neurobiology of obsessive-compulsive disorder (OCD) have raised the possibility that animal models in general and neuroethological models in particular may be useful in understanding and investigating this illness. One neuroethologically oriented model is that of canine acral lick dermatitis. In this report, we review the advantages and limitations of animal models of OCD. Preliminary data on the use of fluoxetine in the treatment of canine acral lick dermatitis are discussed.
Animals↗