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N Sigfússon

Publications and source records attributed to N Sigfússon.

24 records · Page 2Linked to original sources
PubMed1977

Survey of serum lipid levels in Icelandic men aged 34-61 years. An epidemiological and statistical evaluation.

This report presents the results of serum beta-lipoprotein, total cholesterol and triglycerides determinations in a male population surveyed 1967--'68. This was the first stage (stage I) in a prospective health survey conducted by the Icelandic Health Association. The area of study was the city of Reykjavík with adjacent suburbs and communes. The population invited was 1/3 of each of 16 year-groups of males in the age-interval 34-61 years. The population was selected from the National Roster according to birthdays i.e. the 1st, 4th, 7th,.. of each month, the total number being 2.955. The response was 75.1%. B-lipoproteins were determined with the Hyland Beta-L Test, total cholesterol and triglycerides on Technicon AutoAnalyzer (i) according to Technicon Methodology N-24a, and a modification of the method of Kessler and Lederer respectively. Control sera were run in connection with cholesterol- and triglycerides determinations. Serum cholesterol levels were similar to the highest reported from other countries contrary to the triglycerides levels which are in the low range. The mean values and lower centiles are practically independent of age whereas the higher centiles are markedly age-dependent. A seasonal variation for the cholesterol weekly mean values was found. These values were highest in winter and lowest in summer, the difference estimated to be 30-40 mg%. No seasonal variation of triglycerides was found. Centile-flowdiagrams for these blood lipids are presented and the use of similar flowdiagrams is suggested as an aid to bridge a gap between the interpretation of cross-sectional and longitudinal studies.

Adult↗
PubMed1975

A population study of rheumatoid factor in Iceland. A 5-year follow-up of 50 women with rheumatoid factor (RF).

The subject of this paper is a 5-year follow-up of 50 women found with Rose-Waaler Titre greater than or equal 1 : 10 or with a Acryl Fixation Titre greater than or equal 1 : 10 in a general health survey conducted in the Reykjavik area in 1968-1969. The average annual incidence of RA was 2.3 percent. Of four women who died during the follow-up period, three were amongst those with the highest titres. Two of the decreased had cancer mammae and one had lung cancer. Changes in RF-titres and New York Criteria are also discussed. It is suggested that RF-positives could be divided in three different riskgroups.

Adult↗
PubMedDate not supplied

[Survival and trends of ocurrence of left ventricular hypertrophy, gender differences during 1967-1992. The Reykjavík Study.].

OBJECTIVE: We estimated the prevalence and incidence of left ventricular hypertrophy (LVH) in this large prospective cohort study of almost 20,000 participants and identified risk factors in them. Predictive factors of its appearance were evaluated along with morbidity and mortality calculations. MATERIAL AND METHODS: LVH was defined as Minnesota Code 310 on ECG. Everyone with this code at first visit was defined as a prevalence case and those who developed it between subsequent visits were incidence cases. Risk factors at the time of the diagnosis of LVH were determined with logistic regression. Predictive factors for acquiring this ECG abnormality were determined by Poisson regression. The comparison cohort were all other participants in the Reykjavík Study stages I-V. RESULTS: Two hundred ninety-seven men and 49 women were found to have LVH or 3.2% and 0.5%, respectively. The incidence was 25/1000/year among men and 6/1000/ year among women. Prevalence in both genders increased with increasing age. Risk factors at the time of diagnosis were systolic blood pressure (odds ratio pr. mmHg (OR) 1.02; 95% confidence interval (CI): 1.01-1.03), age (OR pr. year: 1.04; 95% CI: 1.02-1.05), silent myocardial infarction (MI) (OR: 3.18; 95% CI: 1.39-7.27) and ST-T changes (OR: 3.06; 95% CI: 2.14-4.38) among men and systolic blood pressure and age for women with similar odds ratio. Predictive factors for acquiring LVH were systolic blood pressure (incidence ratio (IR): 1.01; 95% CI: 1.01-1.02) and angina with ECG changes (IR: 2.33; 95% CI: 1.08-5.02) among men and systolic blood pressure among women (IR: 1.03; 95% CI: 1.01-1.04). In men severe smoking seemed to have a protective effect against developing LVH (IR: 0.36; 95% CI: 0.18-0.71). The risk for coronary mortality was significantly increased among women with hypertrophy (hazard ratio (HR): 3.07; 95% CI: 1.5-6.31) and their total survival was poorer with increasing time from diagnosis of LVH (HR: 2.17; 95% CI: 1.36-3.48). CONCLUSIONS: We conclude that the presence of LVH and its appearance is associated with age and increased blood pressure among both genders. Women with LVH have poorer survival than other women and they are at threefold risk of dying of ischemic heart disease. This could indicate that criteria for detecting LVH on ECG detect both mild and severe hypertrophy among men but only the severe hypertrophy cases among women. More sensitive ECG methods may have to be used to detect mild, moderate and severe LVH among both genders in order to differentiate the severity of LVH based on the ECG diagnosis.

English Abstract↗