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N Stanković

Publications and source records attributed to N Stanković.

At least 19 recordsLinked to original sources
PubMed2005

[Changes in concentrations of sera proteins in war wound].

UNLABELLED: During the general reaction to trauma, substantional changes in protein composition of sera occure. The aim of the prospective study was to investigate net change in total protein and albumin concentrations, as well as albumin/globulin ratio in sera of war casualties during the first 14 posttraumatic days, and to establish the correlation between these changes and severity of trauma. Subjects were 79 war casualties. CONTROLS: 33 blood donors. METHODS: Injury severity was determined according to ISS and blood samples were collected 12 hours after trauma, then on the 1st, 2nd, 5th and 14th posttraumatic day. In war casualties values of total protein and albumin concentrations and albumin/globulin ratio were significantly decreased. Minimal concentrations were measured on 2nd posttraumatic day (589.04 g/l for total proteins, p; 36.66.21 g/l for albumins, p) or on 5th day (0.860.2 for albumin/globulin ratio, p). CONCLUSIONS: During the acute-phase response to trauma, significant changes in concentration of total proteins, albumins and albumin/globulin ratio occure in sera of war casualties. These changes are the most promminent during the first 5 days, with tendency for normalization after that. Intensity of these changes depends of the severity of trauma.

Adult↗
PubMed2003

[C-reactive protein as an indicator of the severity of war injuries].

UNLABELLED: During the general reaction to trauma, acute phase proteins are synthetized. The aim of the prospective study was to determine CRP concentrations in sera of war casualties during the first 14 posttraumatic days, and to establish the correlation between these changes and severity of trauma. Subjects were 79 war casualties. CONTROLS: 33 blood donors. METHODS: Injury severity was determined according to ISS and CRP concentrations with immunonephelometric analysis. Blood samples were collected 12 hours after trauma, then on the 1st, 2nd, 5th and 14th posttraumatic day. In war casualties CRP values were significantly increased (56.257.53 mg/dl after 12 hrs, 107.0976.08 on 1st, 144.3570.23 on 2nd, 71.42558.66 on 5th and 37.656.14 on 14th posttraumatic day; p). Significant differences were observed between groups with ISS and ISS12 (p) in first two days and later between group with ISS24 (144.1766.94 mg/dl on 5th and 111.588.5 on 14th posttraumatic day) and others (p). CONCLUSIONS: During the acute-phase response to trauma, significant changes in concentration of CRP occur in sera of war casualties. These changes are the most prominent during the first 48 hours, with tendency for normalization after the 5th day. Intensity of these changes depend on the severity of trauma. CRP is valid marker of war wound severity.

Adult↗
PubMed1999

[Necrosis of the omental flap].

The aim of this research is to review the frequency of the omental flap necrosis comparing the vascularized omental flaps based on the left or right gastroepiploic vessels. The first 100 patients, with injuries of spinal cord on different levels, are included in this prospective clinical study with follow-up from 12 to 24 months. The special surgical technique was used for preparation of omental pedicled graft, for its lengthening and transposition to the level of the spinal cord injury and direct and indirect signs of the omental flap necrosis were studied. In our patients there was no necrosis of the omental grafts based on the left gastroepiploic artery. The insufficiency of the left gastroepiploic artery was not present in any patient and so it was not the reason of the omental flap necrosis. Devascularisation of the great gastric curvature until to the root of the left gastroepiploic artery, administration of the prophylactic doses of the Heparin and to put gently pressure on the omental flap do not contribute to the appearance of the omental flap necrosis. Based on our experiences and on results of this research we conclude that this way of forming the omental graft can be used for the other omentopexies.

Adolescent↗
PubMed1996

Treatment of wounded in the combat zone.

Authors presented their own experiences in treating 735 wounded in high-intensity combat zones in the territories of former Yugoslavia during 1991 to 1992. The mobile field hospital with surgical crews was situated 5 to 10 km from the front line, and its basic task had been continuous triage, immediate resuscitation with vital surgical aid, as well as organization of adequate primary and secondary air evacuation. At the field hospital level, fresh wounds were explored according to principles of war surgery, and major surgical interventions were performed in 3.3% of the wounded. Patients with massive hematothorax were treated with autotransfusion. Mortality at this primary level, field hospital was 0.75% with primary immediate resuscitation and 1.9% with immediate evacuation. We concluded that immediate resuscitation with delayed transport had advantages, compared with fast evacuation of only the wounded.

Blast Injuries↗
PubMedDate not supplied

[Correlation of size of the primary tumor and axillary node status with the p53 tumor suppressor gene in carcinoma of the breast].

Correlation of standard pathomorphological prognostic parameters, primary tumor size and axillary nodal status with new prognostic factor in breast carcinoma: tumor suppressor gene p53 was analyzed. The studied sample included 65 women who underwent surgery for breast carcinoma at the Surgical Clinic of Clinical Center Banja Luka, from January 1st 1997 till January 1st 1999. Statistical data analysis was performed and correlation of prognostic factors was determined. The majority of authors in this field agree that the primary tumor size and axillary nodal status are the two most important prognostic factors. These factors are the best predictors of prognosis and survival of women who had the tumor and were operated on. Tumor markers were immunohistochemically determined in the last ten years and, according to the majority of authors, are still considered the additional or relative prognostic factors in breast carcinoma. Their prognostic value and significance increase almost daily. Most frequently determined tumor markers are bcl-2, pS2, Ki-67 and p53. There was a positive, directly proportional relationship between primary tumor size and tumor suppressor gene p53, but there was no positive correlation between the axillary nodal status and tumor suppressor gene p53. Significance of determination of new tumor markers as the prognostic factors was emphasized. These markers represent a powerful tool in the early detection and prevention of breast carcinoma.

Axilla↗
PubMedDate not supplied

[Clinical evaluation of serum elastase-1 levels in patients with acute pancreatitis].

The prospective examination and quantitative determination of concentration of serum elastase 1 using RIA method were performed in 75 patients with pancreatic diseases at the Clinic of General and Vascular Surgery and the Institute of Nuclear Medicine of the M.M.A. in the period 1988-1989. The values of serum elastase 1 concentration were compared with values of amylase in serum and urine. The greater diagnostical importance of serum elastase 1 was found compared to values of amylase in serum and urine, not only in patients with acute pancreatitis but also in exacerbation of chronic pancreatitis. The level of serum elastase 1 concentration enables more reliable follow up of the evolution of the disease and therapeutical effects in patients with acute pancreatitis.

Acute Disease↗
PubMedDate not supplied

[Surgical treatment of toxic adenoma].

Sixty eight patients with toxic adenoma (TA) operated on in the period 1985-1992, were analyzed. The manifestation of hyperthyroidism in TA (in 55.88%) significantly depended on the gender of the patients (68.42% in men and 51.02% in women) and on the size of node. In nodes larger than 5 cm in diameter hyperthyroidism appeared in 76.92% of patients and in none with the nodes smaller than 2 cm. The degenerative changes in the nodes depended on pathohystological type of adenoma, and not on the size of nodes. On patohystological examination three carcinomas were found in TA, two papillary and one follicular. The surgical treatment of TA was the optimum way of treatment--the therapy of choice. Along with fast, complete and clear effects, the minimum percentage of complications (4.41%) developed that were mild and of short duration. The enucleation of nodes with capitonnage was absolutely sufficient in the operative treatment.

Adenoma↗
PubMedDate not supplied

[Praziquantel in the treatment of human echinococcosis].

In the period from 1989 to 1993, 73 patients with Echinococcus granulosus cysts were treated by prazyquantel. To differentiate cysts tests of indirect immunofluoroscence and hemagglutination were used. The tests were performed during and after the completed treatment. During the treatment three patients were excluded so that 70 patients completed the treatment. Fifty five (78.9%) patients were treated only with drug with a success of 67% (37 patients). The preventive treatment, due to cyst perforation, was performed in 3 (4.3%) patients. Dissemination of illness occurred in no patients. Twelve (16.8%) patients were treated surgically. The parasite was not alive in 7 (58.5%) patients. The vitality of the parasite was controlled by microscopic examination of protoscolex and by their inoculation into rats of AO strain. The total success of treatment was 67.4% (47) of patients. In two patients the treatment was discontinued due to allergic manifestations. In our opinion, the drug treatment was the therapy of choice in patients with Echinococcus granulosus. It should be given prophylactically, preoperatively, to sterilize the cyst and also as a curative treatment.

Adolescent↗
PubMedDate not supplied

[Antibiotic prophylaxis in elective colorectal surgery].

The prospective clinical examination of 80 patients with the verified carcinoma of the colon and rectum was performed at the Clinic of General and Vascular Surgery of the M.M.A. in the period 1989-1990 with the aim to evaluate efficacy and justified use of antibiotic prophylaxis or prophylaxis and antibiotic therapy after elective surgical intervention. The preoperative mechanical preparation was performed in all patients. The combined metranidazole-gentamycin therapy was applied. In the group of patients receiving antibiotic therapy only, as a short prophylaxis, the postoperative infective complications were recorded in 5% of cases. In the second group of patients receiving antibiotic prophylaxis and therapy these complications were recorded in 10% of cases. The average duration of postoperative hospitalization was 13/14 days in both groups of patients. The use of antibiotic prophylaxis in elective colorectal surgery in patients with carcinoma of the colon and rectum is justified but it is not a substitution for nonadequate surgical intervention.

Colorectal Neoplasms↗
PubMedDate not supplied

[Determination of albendazole and its main metabolite albendazole sulfoxide in the hydatid fluid of human echinococcal cysts using HPLC].

Concentrations of albendazole and its active metabolite in echinococcal cyst of the human liver were determined in order to evaluate drug effects of the decrease of protoscolex vitality. Albendazole concentration of 0-64.9 micrograms/ml and albendazole sulfoxide of 0-40.8 micrograms/ml were found in cysts. The protoscolexes showed markedly manifested morphologic changes up to the disintegration. The postoperative follow up of patients within 24 months discovered no recidives of the disease and the patients were regarded as cured. On the basis of the results obtained it has been concluded that the use of albendazole in the dose of 800 mg/day within 28 day is sufficient for achievement of therapeutic drug level in vivo conditions.

Adult↗
PubMedDate not supplied

[Management of war injuries in Vukovar].

During 42 days of combat operations the brigade medical station provided surgical care for 535 wounded. One third of the wounded (31.8%) were classified in I or II grade of emergency. In the units were returned 21.7% of the wounded. Infusion therapy was applied in 47%. Laparotomy was performed in 7, drainage of the chest cavity in 19 and guillotine amputation of extremities in 11 wounded. The mortality was 1.9% at this stage. The way of management was imposed by combat operations, manpower and means available.

Humans↗