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Biomedical subjects

N Stein

Publications and source records attributed to N Stein.

At least 19 recordsLinked to original sources
PubMed1995

Relationship between suicide and myocardial infarction with regard to changing physical environmental conditions.

In recent years, the possible association of changes in mortality from cardiovascular disease and myocardial infarction (MI) and deaths related to violence and the suicide rate has been repeatedly discussed. This study examined the relationship between cosmic physical changes (solar, geomagnetic and other space activity parameters) and changes in the total number of in-hospital and MI-related deaths and deaths from suicide to determine if a relationship exists between the distribution of total and MI-related deaths with suicide over time; some differences in the serotonergic mechanisms involved in the pathogenesis of MI and suicide were also taken into account. All suicides (n = 2359) registered in the State of Israel from 1981 to 1989 (108 months) were analysed and compared with the total number of deaths (n = 15601) and deaths from MI (n = 1573) in a large university hospital over 180 months (1974-1989). The following were the main features of the Results. (1) Monthly suicide rate was correlated with space proton flux (r = 0.42, P = 0.0001) and with geomagnetic activity (r = -0.22, P = 0.03). (2) Total hospital and MI-related deaths were correlated with solar activity parameters (r = 0.35, P < 0.001) and radiowave propagation (r = 0.52-0.44, P < 0.001), an with proton flux (r = -0.3 to -0.26, P < 0.01). (3) Monthly suicide distribution over 108 months was correlated with MI (r = -0.33, P = 0.0005) and total hospital mortality (r = -0.22, P = 0.024). (4) Gender differences were prominent.(ABSTRACT TRUNCATED AT 250 WORDS)

Cardiovascular Diseases↗
PubMed1994

Topographical differences in sweetness sensitivity in the peripheral gustatory system of adults and children.

The sensitivity of localised areas of the anterior tongue of adults and 8-year-old males to the sweetener sucrose was determined, using a two-alternative forced choice psychophysical procedure. Stimulation of 12 areas by 0.2125 M sucrose or water, using a filter paper technique, indicated that the children were significantly more sensitive to the sweetener at eight of the areas. Counts of papillae at each of the 12 areas showed that there were similar numbers for adults and children at eight areas, whilst at three of the areas that exhibited a higher sensitivity to sucrose, children had significantly more papillae. Since 8-year-old males are less sensitive to sucrose when the stimulus is given as a whole-mouth stimulus [12], it is proposed that the children's gustatory system may be unable to integrate the information available at the tongue as efficiently as adults, or that the threshold and stimulus-response functions of receptor cells are different in the two groups.

Adult↗
PubMed1987

Functional vs. organic pain: a meaningful distinction?

This study examined the statistical and clinical validity of the distinction frequently made between "functional" pain and "real" pain. Earlier work has relied on the MMPI exclusively and results have been inconclusive, yet the distinction continues to be made and treatment is recommended on the basis of the label. Sixty-seven chronic back pain patients were administered questionnaires that assessed quantity and quality of depression, dimensions of illness behavior, and psychogenic attitudes. Scores of chronic pain patients were compared to normal subjects, and results indicate that the pain subjects experienced high levels of depression, anxiety, and social alienation. However, organic pain subjects did not differ from subjects with no organic findings. The authors suggest that the distinction between organic and functional pain be discarded in favor of an approach that assesses current emotional stressors and available coping mechanisms.

Adult↗
PubMed1987

Fine-needle aspiration cytology of prostatic embryonal rhabdomyosarcoma: a case report.

Fine-needle aspiration of the prostate has recently gained popularity as a reliable technique in the evaluation of prostatic nodules for malignancy. The cytologic features of adenocarcinoma have been described, but the features of other more unusual tumors have not been widely publicized. We report a case of embryonal rhabdomyosarcoma of the prostate gland with epithelioid cytologic features.

Adult↗
PubMed1986

Mastery, stress, and coping in marriage among chronic pain patients.

Marital stress, strain, and coping strategies were investigated in chronic pain patients by administering the Problems of Everyday Life Interview (PEL) to 55 married chronic pain patients. Subjects were assigned to either limited, moderate, or heightened mastery groups based upon PEL mastery scores. The heightened mastery group reported less marital strain, less marital stress, more use of negotiation, less use of selective ignoring, and less use of manage-stress coping strategies than either limited mastery or moderate mastery groups. There were no significant differences between limited mastery and moderate mastery groups on any variables measured. There were no differences between mastery groups on advice seeking. The effects of mastery as a mediator of coping and stress are discussed, as well as the advisability of incorporating treatments that specifically address feelings of lack of control over stressful events into chronic pain programs, especially when marital problems are identified.

Activities of Daily Living↗
PubMed1985

Depression and the wish to be held.

The relation between aspects of depression and the wish to be held was studied in 72 male and 57 female college students. Females reported higher levels of depressive experiences associated with issues of dependency as well as more intense wishes to be held. In both sexes the intensity of the wish to be held was related to dependency; however, it was the correlations of these variables with level of depression that revealed differences between males and females. In males, the wish to be held covaried positively with the overall level of depression, Whereas in females it remained invariant across levels of depression. Thus, males who describe themselves as more depressed, relative to other males, expressed more feelings associated with dependency and more intense wishes to be held.

Adult↗
PubMed1985

[Quantitative technics in ultrasonic diagnosis].

This paper presents techniques for computer-aided analysis of medical ultrasonic images. Methods of image processing, feature extraction and a classification algorithm for tissue characterization are described. Based on these techniques a pattern recognition system for semi-automatic analysis of ultrasonic images has been developed and proved within three clinical studies, which aimed to improve the ultrasound diagnosis of the prostate, the thyroid and the female breast. The results show that computer analysis of ultrasonic images is capable of providing a quantitative diagnosis as well as of differentiating tumor lesions by sonography.

Breast Neoplasms↗
PubMed1985

Pending litigation and rehabilitation outcome of chronic back pain.

The effects of pending litigation for compensation on treatment outcomes of patients with chronic low back pain, were assessed. The 81 patients with chronic low back pain who participated in a six-week behavioral treatment program organized around the theme of self-control, were differentiated according to whether there were unsettled legal claims for compensation. Scales from the MMPI and Health Index were administered before and after treatment. Three behavioral measures of physical mobility were obtained from representative subsamples in each group before and after treatment and at one and three months follow-up. Results indicated that after treatment, patients without litigation pending obtained significantly greater reductions on the Hypochondriasis and Hysteria scales of the MMPI and achieved relatively greater improvements on two behavior measures. Because patients with litigation pending also evidenced significant behavioral gains, the belief that these patients are at risk for treatment appears to be true only in relation to the patients without current litigation rather than in an absolute sense.

Back Pain↗
PubMed1983

Experiences of depression and illness behavior in patients with intractable chronic pain.

Studied the relationships between depth of depression, anaclitic and introjective depressive experiences, and dimensions of illness behavior in 37 chronic pain patients. Depth of depression and degree of introjective depressive experiences showed similar positive covariation with a broad range of illness behavior: Namely, hypochondriasis, disease conviction, affective inhibition, affective disturbance, and irritability. The findings suggest that depression characterized by feelings of guilt, worthlessness, and self-doubt, rather than themes of abandonment, is associated differentially with disturbances in the illness behavior of chronic pain patients.

Adult↗
PubMed1982

Neutrophil granulocytic cell antigen defined by a monoclonal antibody--its distribution within normal haemic and non-haemic tissue.

Monoclonal antibodies were raised against normal human bone marrow cells. One of the antibodies obtained, monoclonal antibody 3C4 (MA 3C4), the subject of this paper, was characterised by immunofluorescence studies with viable normal peripheral blood and bone marrow cells and by immunoperoxidase studies using paraffin sections. In bone marrow and peripheral blood MA 3C4 reacts selectively with cells of late neutrophilic granulopoiesis (myelocytes, metamyelocytes, and neutrophilic granulocytes). Cells of erythropoiesis, thrombopoiesis and lymphopoiesis are negative. In lymph node and spleen only neutrophils react with MA 3C4. In non-haemic tissue reactivity was seen with epithelial cells of a variety of different gland ducts. Thus the antigen detected by MA 3C4 can serve as a marker for neutrophil differentiation in normal haemopoiesis and as a marker for ductal epithelial cells of a variety of organs within non-haemic tissue. The antigen is formalin-resistant and can be detected in paraffin sections. The antibody thus appears to be a valuable reagent for both haematological research and for routine pathology.

Antibodies, Monoclonal↗
PubMed1978

In vitro cultivation of human renal cell cancer. II. Characterization of cell lines.

Two cell lines derived from primary human renal-cell cancers (RCC) have been established and characterized. Cell line 786-O has been in culture for longer than 1 year and has been subcultured more than 50 times. It has a doubling time of 45 hr and a hypertriploid karyotype and possesses a Y chromosome. Cell line 769-P also has been in culture for longer than 1 year. It has been subcultured 50 times and has a doubling time of 35 hr and a hypodiploid karyotype. Cells from both lines are epithelial, and they produce tumors in the cheek pouches of immunosuppressed hamsters. Neither cell line is contaminated with Mycoplasma. Cells of the two lines can be distinguished from HeLa cells both by their karyotypes and by the mobility patterns of their isoenzymes of glucose-6-phosphate dehydrogenase.

Adenocarcinoma↗
PubMed1977

Properties of cell lines established from transitional cell cancers of the human urinary tract.

Characterization studies have been carried out on eight cell lines (253J, 192B, 639V, 647V, 486P, 575A,743E, and 751G) established from transitional cell cancers of the human urinary tract. Although subtle morphological differences exist among individual lines, each has an epithelial morphology and exhibits multilayering. The doubling times for the cells range from 20 to 56 hr, and at least a 1-to-3 split can be achieved when they are subcultured every 4th day. Karyotypic analysis revealed a hyperdiploid stemline for each cell line, and presence of a Y chromosome was confirmed by Q banding in five of the lines. The tumorigenic nature of the cell lines was demonstrated by their production of tumors in hamsters and confirmed by colony formation in agar. The transitional cell cancer lines were shown to be free of Mycoplasma, and their glucose-6-phosphate dehydrogenase mobility patterns and their Karyotypes prove that they are not HeLa cells.

Animals↗