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N Sternby

Publications and source records attributed to N Sternby.

10 recordsLinked to original sources
PubMed1998

A multicenter study comparing two endometrial sampling devices--Medscand Endorette and Pipelle de Cornier.

BACKGROUND: To compare two endometrial sampling devices Medscand Endorette and Pipelle de Cornier with respect to tissue collecting ability, diagnostic accuracy and side effects. METHODS: A prospective, multi-center, cross-over study in 152 women with a medical indication for endometrial biopsy. Samples were collected from each patient on the same occasion with both devices, the order of which was randomized. Statistical analysis was based on pairwise comparison in contingency tables with McNemars chi2 test. RESULTS: One hundred and forty-five of 152 (95%) women were successfully sampled. There was no difference between the devices concerning discomfort and bleeding. However, Medscand Endorette seemed to have a higher capacity than Pipelle for collecting an adequate sample. This difference was noted when the two devices were compared in the position as first instrument as well as when results were compared in the main target group for this type of examination, for women over 55 years. CONCLUSIONS: The new Medscand Endorette was preferred due to its higher capacity for collecting adequate samples.

Abdominal Pain↗
PubMed1987

Atherosclerosis in the hypercholesterolemic hare. Comparison of coronary artery lesions induced by dietary cholesterol in the hare and the rabbit.

Atherosclerotic lesions in coronary arteries were compared in 10 hybrid hares and 14 rabbits after induction of hypercholesterolemia, using a cholesterol-enriched diet. All proximal portions of hare coronary arteries contained intimal lesions, often with severe luminal stenosis. These lesions were characterized by the presence of foam cells, smooth muscle cells, and areas of atheronecrosis. Foam cells were also found focally in the media. As part of the intimal changes, iron deposition was present in 65% and calcification was present in 32.5% of proximal segments examined. The proportion of segments with intimal lesions and the intima/media cross-sectional area ratios (I/M ratios) were greatest in proximal segments with stepwise decreases in the mid and distal segments. As area of myocardial infarction was present in one hare. In contrast, 46.5% of proximal segments of rabbit coronary arteries had no intimal lesions and those lesions present had no calcium or iron deposition. No infarction was observed in rabbit hearts. The proportion of segments with lesions and the mean I/M ratios were significantly greater in the hare than the rabbit, with proximal and mid coronary segments showing the most marked differences. The hare appears to develop coronary artery lesions more like those seen in man, with high grade, proximal stenoses occurring uniformly in hypercholesterolemic animals. In contrast, the atherosclerosis developing in rabbit coronary arteries is less uniform and includes involvement of intramyocardial arterioles. The hare offers several advantages as a model of human atherosclerosis.

Animals↗
PubMed1984

Carcinoma of the oesophagus, treated radiologically.

Radiotherapy according to a "small volume/large absorbed dose"-concept was given to 31 patients with carcinoma of the oesophagus. Tumour control in the treated volume was obtained in 52%, but only 13% of the patients survived for 6 years. Metastases outside the treated volume were seen in 65% of the patients. The palliative results may be judged as not optimal.

Aged↗
PubMed1979

Clonal characteristics of experimentally induced "atherosclerotic" lesions in the hybrid hare.

The female hybrid hare (Lepus timidus x Lepus europaeus) is heterozygous for electrophoretically separable, X-linked isoenzymes of glucose-6-phosphate dehydrogenase. The isoenzymes of this animal have been used as cellular markers in the study of the clonal origins of experimentally induced atherosclerotic lesions. Aortic lesions produced in the hybrid hare by feeding cholesterol and injuring the aortic wall with a catheter have been shown to have polyclonal characteristics and in this way are fundamentally different from atherosclerotic fibrous plaques in man.

Animals↗
PubMed1967

Reliability of death certificate data on vascular lesions affecting the central nervous system.

Although it is generally stated that national mortality statistics are to some extent unreliable, it is difficult to ascertain their degree of unreliability. In studies carried out in limited areas of Czechoslovakia, Japan and Sweden it has been possible to determine the cause of death at autopsy in a large series of cases, and the findings relevant to "vascular lesions affecting the central nervous system" (CNS) have been compared with the national mortality statistics for the same causes and with the clinical findings.It was found that death rates for vascular lesions affecting the CNS, taken as a whole, obtained from the autopsy studies were close to the national figures but that the ratio of cerebral haemorrhage to cerebral infarction was lower in the autopsy data, indicating that classification into cerebral haemorrhage and cerebral thrombosis is incorrect in the national figures and that the former is over-diagnosed at the expense of cerebral thrombosis.Comparison of the autopsy data with clinical diagnoses in Prague and Malmö showed that only 70% of the cases of fresh cerebral vascular accidents regarded as the principal cause of death by the pathologist were diagnosed before autopsy, and that many cases found by the pathologist but not considered to be the principal cause of death were not suspected clinically. Less than 1% of cases of cerebrovascular accident regarded as the principal cause of death by the clinician were not found by the pathologist.

Autopsy↗
PubMedDate not supplied

Cholesterol-induced atherosclerosis. Clonal characteristics of arterial lesions in the hybrid hare.

Utilizing the observation that a majority of human atherosclerotic fibrous plaques show monoclonal characteristics, we carried out this study to determine the clonal characteristics of cholesterol-induced atherosclerosis in the hybrid hare. If this is a valid model for human atherosclerosis, the lesions produced in the aorta should be monoclonal. Glucose-6-phosphate dehydrogenase (G-6-PD) was used as an X-linked cellular marker in the female hybrid hare (Lepus timidus X Lepus europaeus), which is heterozygous for electrophoretically separable isoenzymes of G-6-PD. Hares were fed cholesterol over either a 6-month or a 16-month period, and the easily dissectable lesions in the aorta and common iliac arteries were assayed for isoenzyme activity at these times. Of the 93 lesions assayed, all had polyclonal characteristics except a single monoclonal lesion found in an animal fed cholesterol over a 16-month period. Hares fed over the 16-month period showed lesions with isoenzyme patterns having a significantly higher contribution of L. timidus isoenzyme than those found in underlying media. This suggested that a selection of cells with the L. timidus X-chromosome had taken place, but the degree of this selection was not great enough to allow any of the lesions to be defined as monoclonal.

Animals↗