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Biomedical subjects

N Stjernberg

Publications and source records attributed to N Stjernberg.

68 records · Page 4Linked to original sources
PubMed1981

Muscle involvement in sarcoidosis.

In 22 patients with sarcoidosis, symptoms and signs of muscle involvement were scanty, but muscle biopsy showed epithelioid cell granulomas consistent with sarcoidosis in 11 patients (50%). Serial sectioning of the muscle biopsies increased the diagnostic yield. The incidence of muscle involvement was highest among patients with both acute sarcoidosis and erythema nodosum. Involvement of other organs was common in patients with muscle sarcoidosis. In two patients with negative scalene node biopsy and negative bronchial and transbronchial biopsies, muscle biopsy showed histological evidence of sarcoidosis. Muscle involvement is common in patients with sarcoidosis, but in many cases there are few or no symptoms. In patients with both acute sarcoidosis and erythema nodosum, muscle biopsy frequently provides histological evidence of the disease. Good cooperation with the pathologist and serial sectioning of the biopsies are necessary if muscle biopsy is to be used as a routine in the diagnosis of sarcoidosis.

Adult↗
PubMed1980

Flexible fiberoptic bronchoscopy in sarcoidosis.

Twenty-nine patients with clinical signs, chest X-ray and histology consistent with sarcoidosis have been studied with flexible fiberoptic bronchoscopy (FFB) and scalene node biopsy. The diagnostic yield from bronchial mucosal biopsies was 41%, and from transbronchial lung biopsy 43%. 52% of the patients showed epithelioid cell granulomas with FFB (lung and/or mucosal biopsies) compared with 79% with scalene node biopsy. Three patients showed extensive bronchial mucosal changes with stenosing processes due to sarcoidosis. Sarcoidosis of the bronchial mucosa is a frequnt finding, and FFB is the best method for discovering bronchial mucosal sarcoidosis with or without stenosing processes. In our opinion, FFB has a place as a routine method in diagnosing sarcoidosis.

Adult↗
PubMed1980

Scalene node biopsy in sarcoidosis.

Scalene node biopsy was performed by a trained surgeon in 39 patients with established sarcoidosis. The diagnostic yield in this group was compared wtih the results in 43 patients with established sarcoidosis who had been subjected to routine scalene node biopsies at the same clinic. Sarcoid tissue was found in 82% of the patients operated on by the trained surgeon compared with 47% in the other group. It is concluded that, in the hand of a trained surgeon with a good operating technique. scalene node biopsy is a good alternative for obtaining tissue from sarcoidosis patients for histopathological examination.

Adult↗
PubMed1976

Flexible fiberopitc bronchoscopy in the diagnosis of bronchial carcinoma.

Forty-eight patients with primary bronchial carcinomas have been examined, and 41 of these carcinomas (85%) were confirmed by histopathological or cytological tests on samples taken during flexible fiberoptic bronchoscopy. Thirty-seven patients (77%) were diagnosed histopathologically, based on forceps biopsy, and four cases cytologically, based on investigations of bronchial secretions and brush biopsies. In nine of 14 patients with peripheral tumours the diagnosis was verified by flexible fiberoptic bronchoscopy. We find this a very safe and useful method in the early diagnosis of bronchial carcinoma.

Adenocarcinoma↗
PubMedDate not supplied

Association between orosomucoid types and cancer.

Orosomucoid (ORM) is a polymorphic acute-phase reactant with immunosuppressive properties. Previous investigations have suggested that ORM and other acute-phase reactants may act as blocking factors protecting tumor cells against immunological attack, thereby contributing to the 'immune escape' of the tumor. ORM types were studied by isoelectric focusing and immunoprinting in patients with carcinoma of the breast, lung, ovary and endometrium and in population controls. In accordance with a previous study, the frequencies of the ORM1*2 allele and the ORM1 2 phenotype were found to be significantly increased in patients with different types of carcinomas. The results suggest that the ORM1 2 variant may influence the progression of cancer by being more immunosuppressive than the ORM1 1 variant. The relative risk for carcinoma in patients with the ORM1 2 type was 1.56 (95% confidence interval:1.16-2.09).

Alleles↗
PubMedDate not supplied

Pre- and postoperative respiratory muscle strength in primary hyperparathyroidism.

Muscle function in ten hyperparathyroid patients and six patients with benign thyroid disease was assessed by measuring maximal expiratory (Pe max) and inspiratory (Pi max) pressures before and 6-12 months after neck surgery. Pe max was improved in all the hyperparathyroid patients postoperatively (p less than 0.002), while the median value of Pi max was unchanged. In the control (thyroid) group there was no significant postoperative change in either Pe max or Pi max. It is concluded that normalization of hypercalcemia improves respiratory muscular capacity, which can be quantified by measuring maximal expiratory pressure.

Adenoma↗
PubMedDate not supplied

Biological markers of exposure to SO2: S-sulfonates in nasal lavage.

S-sulfonate levels were measured in the nasal lavage (NAL) fluid of humans exposed to sulfur dioxide as a potential biological marker of exposure. These levels were determined by treating NAL fluid protein with cyanide to cleave the S-S linkage and release the sulfite. The cyanolytically released sulfite was measured by ion chromatography. In two experiments, humans were exposed to air or 1 ppm SO2 for 10 minute, and to air or 7 ppm SO2 for 20 minutes and lavaged immediately after exposure. Releasable sulfite levels in NAL fluid were 1.06 +/- 0.24 and 2.61 +/- 0.55 micrograms SO=3/mg protein, respectively (mean +/- SE, n = 5), for the first experiment, and 1.16 +/- 0.37 and 4.91 +/- 0.76 micrograms SO=3/mg protein, respectively (mean +/- SE, n = 8), for the second. The subjects in the former study were persons with asthma. In both experiments, S-sulfonate levels were statistically elevated in the exposed group compared with the control groups (p < 0.05, paired t-test). The same individuals in the second experiment received five additional 20-minute exposures to 7 ppm SO2 every other day, for a total of six exposures. NAL fluid taken at the conclusion of the final exposure had releasable sulfite levels of 4.99 +/- 1.36 micrograms SO=3/mg protein; these levels were statistically elevated relative to controls but were not elevated relative to the 1-day exposure (mean +/- SE, n = 8). The lack of accumulation of S-sulfonates after 6 days of short-term exposure suggests clearance of these compounds from the nasal passages within 24 hours. The levels of S-sulfonates observed in NAL fluid in this study are almost three orders of magnitude higher than those measured in plasma following similar SO2 exposures. Measurement of S-sulfonates in the nasal passage may be an effective short-term biomarker of exposure to SO2.

Adolescent↗