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N T Gorman

Publications and source records attributed to N T Gorman.

41 records · Page 3Linked to original sources
PubMedDate not supplied

Wide local excision of acanthomatous epulides in the dog.

Twenty-five dogs bearing acanthomatous epulides of the oral cavity underwent tumor resection by wide local excision. The surgical procedures included rostral mandibulectomy, removal of the mandibular body, premaxillectomy, and partial maxillectomy. Postoperative complications were rare, and local recurrence was not encountered in any dogs over periods of 1 to 6 1/2 years (median, 22 months). The authors conclude from the high incidence of local recurrence after simple excision through the tumor margins and the potential for malignant transformation after irradiation that wide surgical resection is the technique of choice for the management of acanthomatous epulis.

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PubMedDate not supplied

Multi-drug resistance genes in the management of neoplastic disease.

P-gp can function as an ATP-dependent cytotoxic drug-efflux pump. In normal tissues, protein expression is localized to cell surfaces that face excretory lumina; hence, P-gp may function as a toxic-waste disposal system. Tumors that are derived from these tissues can be high expressors of P-gp, and these tumors tend to display intrinsic chemoresistance. Other non-expressing tumors can become P-gp positive after treatment or at relapse, suggesting that mdr may be involved in acquired resistance. The use of MDR-modifying agents has had some clinical success, and further trials of chemosensitizers are proceeding. P-gp overexpression does not explain how clinical resistance to anthracyclines, alkylating agents, and cis-platinum can arise simultaneously. In these cases, multiple genetic mechanisms of resistance may coexist. Eventually, mdr status can be used to select the most effective chemotherapy protocol for the individual. Currently, conversion of a previously mdr negative tumor to mdr expression, in the face of clinical resistance, justifies changing to a non-MDR drug protocol, or if not feasible, the use of MDR sensitizers.

ATP Binding Cassette Transporter, Subfamily B, Mem↗
PubMedDate not supplied

Microwave hyperthermia in the treatment of spontaneous canine tumours: an analysis of treatment parameters and tumour response.

Fifty-one spontaneous canine tumours were treated with combined radiation and hyperthermia in a pilot study designed to investigate the feasibility and efficacy of the combined modality treatment in the dog. The tumours varied in site and histological type: 35 were in the oral cavity and included squamous cell carcinoma, melanoma and various 'sarcomas'. All animals received radiation (36-40 Gy in four weekly fractions) and post-irradiation hyperthermia (prescription -44 degrees C for 30 min) on one or two occasions. The microwave hyperthermia system was technically satisfactory in elevating tumour temperature to 44 degrees C or above in 95 per cent of treatments. However, thermal gradients of the order of 3-5 degrees C were frequently measured across the tumour, and rarely did all peripheral points achieve the target of 44 degrees C for 30 min. The overall tumour response rate (CR + PR) was 87.7 per cent with 60.7 per cent of tumours achieving complete regression. Smaller lesions showed a significantly greater response rate (P = 0.004) and those lesions which received two thermal treatments show an increased response (P = 0.0095). Fifty-one per cent of tumours showed significant necrosis following hyperthermia. Normal tissue necrosis was seen in three patients; in two cases this was attributed to hyperthermia. Local tumour control rate and necrosis was not correlated with measured minimum, mean or maximum thermal doses.

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