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Biomedical subjects

N Tomassini

Publications and source records attributed to N Tomassini.

At least 37 records · Page 2Linked to original sources
PubMed1982

RBC destruction caused by a micropore blood filter.

Two infants who received whole blood filtered through commercially available woven stainless steel micropore filters experienced a sudden onset of hemoglobinuria. The plasma hemoglobin level in one child was 200 mg/dL. To investigate whether filters might lead to RBC destruction, we experimentally quantitated filter-induced hemolysis using standard conditions. Our studies in vitro show that hemolysis decreases with increased speed to transfusion. Hemolysis is particularly extensive with blood stored more than 14 days, but measurable hemolysis occurs with blood stored for as little as one day.

Blood↗
PubMed1982

[Papillomatosis of the bile ducts: a clinical case].

A case of diffuse papillomatosis of the bile duct, treated with external biliary drainage, is reported on account of its rarity. The extent and anatomopathological characteristics of the lesion make radical surgery impossible, so that the above-stated surgical solution appears to the Authors to be the most suitable one for resolving the biliary stasis and consequent cirrhosis.

Aged↗
PubMed1982

Preservation of brush border transport systems for proline and alpha-methyl-D glucoside from rat, dog, and human kidney.

The effects of freezing renal tissue from rat, dog, and man on the time course of uptake of proline and alpha-methyl-D-glucoside by subsequently isolated brush border membrane vesicles was examined and compared with uptake patterns by membranes isolated from tissue that had never been frozen. The overshoot phenomenon was used as the critical criterion for viability of the transport systems. Membranes isolated from frozen rat and dog kidney possessed intact transport systems for proline and alpha-methyl-D-glucoside capable of producing normal or even enhanced overshoot patterns. Freezing human kidney prior to membrane isolation resulted in severe impairment of the vesicle transport capabilities. Freezing a crude membrane suspension, however, allowed the subsequent purification of only partially intact systems.

Animals↗
PubMed1980

[Biliary ileus: reflections on one clinical case (author's transl)].

The authors describe one case of biliary ileus occurring in the form of stepwise intestinal obstruction, successfully treated by surgery designed to resolve the obstruction and at the same time repair the biliodigestive fistula. Because of the high postoperative morbidity and mortality in emergency cases, this operation should be reserved in the authors' opinion to patients in satisfactory humoral balance and in the absence of general contraindictions.

Aged↗
PubMed1970

Morphological aspects of the uptake of simian virus 40 by permissive cells.

After exposure of permissive cells to simian virus 40 (SV40), single particles were engulfed by the cell membrane and transported to the nucleus. The cell membrane closed tightly around the particles, increasing their diameter from 40 to 55 nm. The cell membrane was lost during interaction with the nuclear membranes, and particles of the original size were found in the nucleus 1 hr after infection. Uncoating of these nuclear particles occurred rapidly, and none could be found 4 hr after infection. Viral progeny appeared 24 hr after infection.

Animals↗
PubMed1969

Early events in herpes simplex virus infection: a radioautographic study.

The early events in herpes simplex virus infection were studied by means of radio-autography. The virus was rapidly taken up by the host cells and uncoated. Viral deoxyribonucleic acid (DNA) reached the nuclear sites of replication in 15 to 30 min after infection. The viral DNA occasionally associated with chromosomes or condensed chromatin but was more frequently found to be randomly distributed. Viral progeny appeared 3 hr after infection. These particles did not show any particular spatial relationship to the parental DNA. The morphological latent period lasted 2.5 hr.

Animals↗
PubMed1968

Morphology of the nucleoprotein component of rabies virus.

The intracytoplasmic ground substance, or matrix, associated with the development of rabies virus and the nucleocapsid of the virus were investigated. The filaments of the matrix were identified as virus-specific by means of ferritin-labeled antibodies. In thin sections, the diameter was 15 nm and the strands seemed to be incorporated into virions during morphogenesis of the virus. The nucleocapsid was isolated from purified virus preparations and was studied in negative contrast. The rabies nucleocapsid appeared as a single-stranded helix with a diameter of 16 nm and a periodicity of 7.5 nm; its length was in excess of 1 mum.

Chemical Phenomena↗