Biomedical subjects

N Trabert

Publications and source records attributed to N Trabert.

3 recordsLinked to original sources

PubMed1979

Digoxin-prescribing. Mostly good news.

We examined digoxin-prescribing in 47,000 prescriptions written predominantly by physicians in a large family medicine practice. Two hundred fifty-four patients received 511 digoxin prescriptions. Dose adjustments for age (16% decrease in patients older than 64 years), for renal disease (33% decrease), and for atrial fibrillation (39% increase) followed good prescribing practices. Appropriately lower loading doses were used for digitalization. However, despite continuing concern over the bioavailability of generic digoxin tablets, less than 40% of digoxin prescriptions in this study were written for the innovator's brand-name product (Lanoxin).

Adult↗

PubMed1975

Imipramine-mediated interference with levodopa absorption from the gastrointestinal tract in man.

The effect of imipramine on the absorption of a single dose of levodopa was studied in male volunteers. By delaying gastric emptying and retarding delivery to intestinal absorptive sites, imipramine interfered with the absorption of levodopa. This action caused by the anticholinergic effect of imipramine. The retardation of transit of levodopa also caused the elaboration of therapeutically inactive metabolites of levodopa in the gastrointestinal tract. Antidepressants and levodopa are often given together, and this combination may interfere with the absorption and efficacy of levodopa in the treatment of Parkinson's disease.

Adult↗

PubMed1975

Imipramine-caused interference with levodopa absorption from the gastrointestinal tract in rats.

Rats treated for 3 or 30 days with imipramine (30 mg/kg) have impaired absorption of a single dose of 14C-levodopa. Treated animals retain larger amounts of radioactivity in their gastric lumen and this interfers with delivery of levodopa to intestinal absorptive sites. Tissues of treated animals have lower levels of radioactivity than controls and urinary excretion of radioactivity is also lessened. Imipramine does not interfere with uptake of levodopa by everted sacs of rat jejunum. Imipramine does, however, interfere with the transit of radioactivity through the gastrointestinal tract of rats, since treated animals have lower ileal radioactivity than controls. Lower relative concentration of levodopa metabolites in gastric fluid and tissue may reflect an interference of uptake of levodopa by gastric enterochromaffin-like cells.

Animals↗