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Biomedical subjects

N V Anderson

Publications and source records attributed to N V Anderson.

At least 37 records · Page 2Linked to original sources
PubMed1982

Effect of dietary vitamin E on immune responses of calves.

The effect of vitamin E on humoral and cell-mediated immune responses in calves was determined, and plasma vitamin E and immunological status of calves under normal herd management were studied. Twelve newborn calves were fed skimmed colostrum for 2 days and thereafter skimmed milk plus vitamin E-stripped lard and emulsifying agents. Six calves each orally received 0, and six each orally received 1 g of DL-alpha-tocopherol acetate daily. Rations were supplemented with trace minerals and vitamins A and D. Twenty calves were fed colostrum for 3 days and thereafter milk and dry feed. At 6 wk, mean plasma vitamin E concentrations (micrograms/100 ml) for groups were 71, 639, and 155, respectively; and mean serum glutamic oxalacetic transaminase concentrations (IU/liter) were 320, 61, and 43, respectively. Mean serum immunoglobulins concentrations (mg/100 ml) were: G1, 1079, 1168, and 1315; G2, 488, 562, and 432; A, 37, 53, and 35; M, 151, 118, and 110. Mean lymphocyte stimulation indexes were 76, 220, and 152, respectively. At 6 wk there were large but nonsignificant differences in mean indexes among groups.

Age Factors↗
PubMed1978

Morphologic evaluation of IgM cells of the canine small intestine by fluorescence microscopy.

Biopsies of small intestine from 7 dogs were examined by fluorescence microscopy to determine the number of IgM-containing cells in the lamina propria. Biopsies were taken from duodenum, jejunum, and ileium. (Cell counts were made by 2 persons to demonstrate reproducibility.) There were 452.24 +/- 60.09 cells per mm2 in the duodenum 572.68 +/- 62.13 cells per mm2 in the jejunum, and 107.47 +/- 59.57 cells per mm2 in the ileum. All sections were cut at 6 micrometer. The ileum had fewer cells than either duodenum or jejunum (P = 0.000038 and 0.00001, respectively), whereas duodenum and jejunum did not differ significantly in numbers of cells (P = 0.17528). Quantifying autofluorescent cells in the same sites showed no significant differences among the 3 tissues (P = 0.24697). The autofluorescent cells differed in intensity and morphology from the IgM cells. These two observations tend to support the contention that the autofluorescent cells did not bias the IgM cell counts at the 3 sites. Total autofluorescence (cells, collagen, and vessels) was higher in the ileum than in either the jejunum or the duodenum (P = 0.04967 and 0.03050, respectively). However, all 3 categories counted (IgM cells, autofluorescent cells, and autofluorescent structures) had significant dog-tissue interactions. This will necessitate determining normals for each age-sex-breed category of dog studied.

Animals↗
PubMed1976

Effect of staphylococcal alpha-toxin pancreatitis on glucose tolerance in the dog.

Acute pancreatitis was experimentally produced in dogs to study the effect of the disease on glucose tolerance. The k value (glucose disappearance coefficient measured in percentage decrease of glucose/min) calculated from the high-dose intravenous glucose-tolerance test was used to evaluate the glucose tolerance of each dog. Thirty dogs were allotted to 3 groups of 10 dogs each as follows: group I--nonsurgical control dogs; group II--surgical control dogs; and group III--pancreatitis-affected dogs. To increase their susceptibility to diabetes, 50% partial pancreatectomies and ductal catheterizations were performed on group II and III dogs. Saline solution was infused into the ductal systems of group II dogs, and staphylococcal alphatoxin was infused into the ductal systems of group III dogs to produce pancreatitis. The results indicated that (1) high-dose intravenous glucose-tolerance test was an effective tool for determining decreased glucose tolerance in dogs; (2) glucose tolerance of group III dogs was markedly decreased compared with that of group I and II dogs; (3) staphylococcal alpha-toxin produced signs of moderately severe pancreatitis; and (4) 50% partial pancreatectomy and saline solution infusion produced clinical and clinicopathologic signs of mild pancreatitis. To determine if a simplified k value (calculated using 2 or 3 blood samples) could closely approximate the standard k value (calculated using 6 blood samples), simplified k values were derived from the 5- and 60-minute blood sample values. These values closely approximated the standard k values, indicating the simplified value may be used in the clinical situation. The standard k value, however, is preferred for investigative work.

Animals↗
PubMed1975

Projectile expectoration associated with an esophageal diverticulum in a cow.

An adult Milking Shorthorn cow developed a pulsion diverticulum of the esophagus, close to the esophageal hiatus. Clinical signs were loss of condition and projectile expectoration of chewed ingesta, as far as 2 m, accomplished by forceful expiration clearing the regurgitated ingesta from the pharynx. The lesion was detected by digital palpation through the cardia, via a rumenotomy incision.

Animals↗