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N V Anikina

Publications and source records attributed to N V Anikina.

18 recordsLinked to original sources
PubMed1994

[Tramadol in the vascular pains of patients with systemic scleroderma and other rheumatic diseases].

A study was made of the effect of tramadol on vascular pains in 20 patients with systemic scleroderma and other rheumatic diseases, using a visual analogue scale. In eleven patients, ischemic and ulceronecrotic lesions were at the basis of the painful syndrome. In this case the pains were most severe. In five patients, the lesions were of vascular and neuromuscular character. 50% of the patients demonstrated a good effect, 35% a satisfactory one, and 10% had a complete analgesia. Tramadol was administered in a daily dose of 100 to 200 mg, mainly per os. It is recommended that tramadol may be used in patients with the painful syndrome of vascular genesis.

Adolescent↗
PubMed1993

Interferon system in patients with rheumatoid arthritis and sclerodermia systematica.

In the blood of patients with rheumatoid arthritis and/or sclerodermia systematica usually acid-labile interferon-alpha (IFN-alpha) was found. Blood leukocytes cannot be considered the source of its production as they spontaneously produce IFN-gamma identified with specific antiserum. Blood leukocytes of tested patients generated in vitro a reduced amount of staphylococcus enterotoxin A-induced IFN-gamma and virus-induced acid-labile IFN-alpha. This findings support the assumption of impaired functioning of T- and B-blood cells in autoimmune diseases. The production of Newcastle diseases virus-induced IFN-alpha and influenza virus-induced acid-stable IFN-alpha by patients' leukocytes has not been altered. Acid-labile IFN-alpha obtained from the blood of tested patients, IFN-gamma spontaneously generated by leukocytes in vitro and acid-labile IFN-alpha produced by leukocytes in vitro following induction with influenza virus show similar sensitivity to pH 2.0 and time patterns of the antiviral state development in human diploid fibroblast culture.

Adult↗
PubMed1992

[The clinico-functional assessment and work capacity of patients undergoing repeated operations on the mitral valve].

A complex of examinations (ECG, echocardiographic and X-ray evaluations of heart volumes and cavities, treadmill-test) was performed in 82 patients before and after reoperations on the mitral valve. The type of recorrection was found to be associated with the degree of positive dynamics of the results. The data obtained contradicted to hyperdiagnoses of primary medical-labor examination commission establishing the II group of invalidism in 86 +/- 4% (M +/- m) of the examined patients. As a result of an analysis of all the data obtained the number of such patients was reduced up to 34 +/- 5%. A new approach to solving the problem of medical-labor examination was shown to be necessary for patients reoperated for mitral disease of the heart.

Adult↗
PubMed1992

[The use of Capoten in systemic scleroderma].

Experience gained with the use of captopril has been summarized in 5 patients with sclerodermic renal crisis (true sclerodermic kidney) as well as the results of the double blind clinical trial of captopril in 16 patients with Raynaud's syndrome. Captopril given for a long time in the dose 75-150 mg to the patients with true sclerodermic kidney turned out effective which showed up by a decline and stabilization of arterial pressure, decrease of the intensity of azotemia and headaches, and stabilization of renal function. No convincing data have been obtained, that may confirm a beneficial effect of captopril on Raynaud's syndrome. The drug was applied in a dose of 37.5 mg for 2 weeks.

Acute Disease↗
PubMed1991

Markers of collagen and basement membrane metabolism in sera of patients with progressive systemic sclerosis.

The concentrations of the amino terminal propeptide of type III procollagen, the 7S domain of type IV collagen, and the fragment P1 of laminin (PIIINP, 7S, and P1 respectively) and the activity of galactosylhydroxylysyl glucosyltransferase (GGT) in serum were evaluated as indicators of disease activity in a cross sectional study of 84 patients with progressive systemic sclerosis. The mean values of PIIINP, P1, and GGT were raised in progressive systemic sclerosis, 19-32% of patients having abnormal values of the various tests. PIIINP, measured with two different assays, and P1 were associated with active, acute, or subacute disease. GGT also correlated positively with some acute phase proteins in the whole group, without a clear association with the course of the disease. Arthritis was associated with increased PIIINP concentrations as well as with an increased activity of GGT. Kidney disease led to raised concentrations of the degradation products of PIIINP. Raynaud's phenomenon in the hands was related to increased PIIINP concentrations.

Adult↗
PubMed1990

[New markers of collagen and basal membrane metabolism and kidney involvement in systemic scleroderma].

The study was made within the framework of the Soviet-Finnish cooperation and represents a fragment of work pertaining to the clinical trials of new markers of metabolism of collagen and basal membranes in patients afflicted with systemic scleroderma (SSD). Sufficient clinical material (84 SSD patients) and radioimmunoassays were employed to study the clinical significance of aminoterminal propeptide of type III procollagen. In SSD patients with renal impairment (n = 34) and without it, PIIINP and PIIINP-Fab, serum galactosyl hydroxylysylglucosyltransferase and two antigens of basal membranes-7S-domene of type IV collagen and PI-fragment of laminine were determined. Renal impairment was established to correlate with serum concentration of PIIINP-Fab (p less than 0.007). PI-fragment of laminine. The parameters under study correlated as well with the disease course, the presence of arthritis and the Raynaud's syndrome gravity and can be regarded as markers of the disease activity and high fibrous formation lying at the basis of SSD.

Adolescent↗
PubMed1989

[The effect of dimethyl sulfoxide on the thromboelastographic indices and the microcirculation in patients with rheumatic diseases].

Using a blind method for assessing the results, a study was made of the effect of dimethylsulfoxide (DMSO) on fibrin formation and microcirculation in 42 patients with rheumatic diseases (rheumatoid arthritis, systemic scleroderma, Raynaud's syndrome). It has been shown that the therapeutic effect of DMSO in rheumatic diseases is determined to a definite degree by its normalizing action on fibrin formation and microcirculation.

Dimethyl Sulfoxide↗
PubMed1986

[Microcirculatory disorders in the genesis of sclerodermic nephropathy].

Biomicroscopy of the vessels of the conjunctiva (BMV), the determination of erythrocyte and platelet aggregation capacity and investigations of the effective cutaneous and muscular blood flow and blood plasma renin activity were employed to study microcirculation in 110 patients with systemic sclerodermia (SSD) (74 with and 36 without renal lesion). The detected disturbances were correlated with the nature and gravity of sclerodermic nephropathy (SN). In BMV the frequency of intravascular platelet aggregation increased with a rise of the gravity of renal pathology. The quantitative determination of erythrocyte and platelet aggregation capacity revealed a significant acceleration of the aggregation of the blood cell elements in the SSD patients which correlated with SN presence and gravity as well as with renal function indices. Renin plasma activity was significantly raised in patients with severe renal pathology. There was correlation between the indices of function of the kidneys and ultrastructural signs of lesion of their microcirculatory bed. The results of the study served as a basis for the differential use of vascular drugs and the development of new pharmacotherapeutic methods for SSD patients with renal lesion.

Adolescent↗
PubMed1985

[Correction of microcirculatory disorders in rheumatic diseases].

The present article is concerned with the problems of pharmacotherapy of microcirculatory disorders (MD) in rheumatic diseases (RD) and with the complex of methods permitting one to judge the intensity of the pathological process at the microcirculatory level. Based on the study of the problems of the correction of MD in more than 300 patients with RD the vasospastic, ischemic, cutaneotrophic, renal and pulmorenal syndromes as well as the DIC syndrome were recognized which require the correction therapy. Differentiated therapy including heparin, deaggregating agents, rheopolyglucin and peripheral vasodilators should be performed with regard to the degree of blood rheological properties derangement and tendency of alterations in the hemostatic potential. To evaluate the treatment, efficacy, biomicroscopy of the vessels of the eyeball conjunctiva and laboratory standardized methods for hemostasis study are the most available techniques.

Administration, Oral↗
PubMed1985

[Clinico-morphological characteristics and working classification of kidney diseases in patients with systemic scleroderma].

Based on a study of 110 patients with systemic scleroderma (SSD) (74 had involved and 36 uninvolved kidneys) the authors provide the clinico-functional and morphological characteristics of renal lesions and the working classification of sclerodermic nephropathy (SN). The two basic variants of SN were recognized: acute and chronic. The latter one was subdivided into clinical, moderate and pronounced SN. A correlation was revealed between the functional (glomerular filtration lowering) and ultrastructural (reticulation of endotheliocytes and thickening of the basal membrane of the glomerular capillaries) signs evidencing derangement of the microcirculatory bed. Morphological examination of the kidneys disclosed alterations that mirror the complex pathogenesis of SSD: derangement of the microcirculatory bed, immunopathological disorders, activation of connective tissue components.

Adolescent↗
PubMedDate not supplied

[Differential diagnosis of diffuse eosinophilic fasciitis].

The authors studied clinical course, morphological findings, condition of microcirculation in 22 patients with diffuse fasciitis++ in comparison with 20 patients with systemic scleroderma and 20 patients with other similar diseases. Comparing clinico-laboratory data of 62 patients sharp differences were observed between diffuse fasciitis++ and systemic scleroderma. In diffuse fasciitis++ microcirculation disorders were less marked than in systemic scleroderma. According to the above research diffuse eosinophilic fasciitis++ is considered to be an independent nosologic form.

Diagnosis, Differential↗