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N V Bobkova

Publications and source records attributed to N V Bobkova.

15 recordsLinked to original sources
PubMed1992

Dissociation of multiple behavioral effects between olfactory bulbectomized C57Bl/6J and DBA/2J mice.

The behavioral effects of bulbectomy and subsequent antidepressant treatment in two mice strains were compared on measures of open field behavior and passive and active avoidance 2 and 4 weeks after surgery. After bulbectomy, both strains displayed elevated locomotion in open field, corrected by antidepressants. Enhanced rearing was decreased by antidepressants in C57Bl/6J, but not in DBA/2J mice. Passive avoidance, being intact 2 weeks after surgery in both strains, was strongly impaired 4 weeks after bulbectomy in C57Bl/6J mice, with antidepressants restoring the performance. Active avoidance acquisition and retention were also dramatically disturbed in C57Bl/6J mice 2 and 4 weeks after surgery, and antidepressants had recuperative effect. In contrast, bulbectomized DBA/2J mice didn't show any significant passive or active avoidance deficits, and antidepressant treatment seemed to have no effect on their learning ability. The observed strain differences suggest that bulbectomy may produce quite diverse neurophysiological and neurochemical alterations in two strains.

Amitriptyline↗
PubMed1989

[The role of the brain monoaminergic systems in the anti-alcohol action of dermorphin and the delta-sleep peptide].

The effects of dermorphin and DSIP were studied in male Wistar rats chronically treated with ethanol. Both peptides (200 mg/kg, i. p., daily during 10 days) significantly reduced volitional alcohol intake for 3-4 weeks. These effects were associated with a marked decrease in serotonin and its metabolite 5-HIAA levels in the hypothalamus. The findings suggest that antialcoholic effects of both peptides are actualized through mechanisms involving serotoninergic system of the brain.

Alcohol Deterrents↗
PubMed1988

[Effect of the active immunization of rats with a serotonin-protein conjugated antigen on the content of biogenic amines in the brain and on behavioral reactions].

Active immunization of rats with conjugated antigen serotonin-protein decreased the level of serotonin and its metabolite 5-hydroxyindole-3-acetic acid in some brain structures as well as the level of dopamine in the hypothalamus. The induction of antibodies to serotonin decreased the horizontal movement activity in the animals.

Animals↗
PubMed1986

[Monoamines and peptidergic Gomori-positive neurosecretory cells of the paraventricular nucleus of the rat hypothalamus in chronic alcohol consumption].

For 6 months the rats were kept on 20 degrees ethanol. Then, the rats could choose whether to drink alcohol (A) or water. The rats formed 2 groups: those preferring A and those preferring water. The control rats were kept on water. The function of hypothalamus monoamine- and peptidergic systems were disturbed following chronic A treatment. Alcohol-preferring, unlike water-preferring rats, have revealed higher hypothalamus levels of serotonin and lower levels of dopamine and noradrenaline, which correlated with changes in fluorescence intensity of hypothalamus noradrenaline structures and were accompanied by remarkable disturbances in nonapeptide neurohormone transport in the paraventricular nucleus region.

Alcohol Drinking↗
PubMed1986

[Increased efficacy of teturam combined with L-DOPA in experimental alcoholism in the rat].

In an experiment on Wistar male rats the authors studied the effects of teturam, diethyldithiocarbamate and Esperale in combination with L-DOPA on the consumption of alcohol and metabolism of biogenic amines in the brain. The use of L-DOPA prolonged the inhibitary effect of teturam on alcohol consumption. The administration of L-DOPA following Esperale implantation prevented the development of the abstinence syndrome. An increase in the efficacy of teturam and Esperale under the effect of L-DOPA was attended by elevated synthesis of cerebral noradrenaline.

Alcohol Deterrents↗
PubMedDate not supplied

Influence of local injection of 5,7-DHT and 6-OH-DA into the neocortex on learning and exploratory behavior of rats in the open field.

The features of the exploratory behavior in the open field, of the learning of a conditioned-reflex food-procuring reaction, and of the shift in the level of biogenic amines of the brain was studied in Wistar rats with local injections of the specific neurotoxins 6-hydroxydopamine (6-OH-DA) and 5,7-dihydroxytryptamine (5,7-DHT). It was shown that damage to the structure of the serotoninergic or catecholaminergic systems of the frontal cortex and hippocampus caused by local injection of 6-OH-DA and 5,7-DHT into the neocortex is accompanied by multidirectional changes in the exploratory behavior and learning of the animals.

5,7-Dihydroxytryptamine↗
PubMedDate not supplied

Influence of active immunization of rats with conjugated serotonin-protein antigen on the content of biogenic amines in the brain and on behavioral responses.

The influence of induction of antibodies to the neuromediator serotonin in the case of active immunization of animals with a conjugate serotonin-protein antigen on the distribution of biogenic amines in the brain and on behavioral responses was investigated in experiments on rats. It was shown that active immunization of rats with a serotonin-protein conjugate leads to a decrease in serotonin, its metabolite 5-hydroxyindole-3-acetic acid, as well as dopamine in certain brain structures. Against a background of induction of antibodies to serotonin, the horizontal motor activity of the animals is decreased.

Animals↗
PubMedDate not supplied

[Rearrangement of the spatial synchronization of the stratified activity of the cortex during the orienting response and upon stimulation of the nuclei of the brain stem reticular formation and mammillary bodies].

In experiments on alert rabbits it was shown with the help of correlational-spectral method that the rearrangement in the spatial organization of the activity of the first and the fifth layers in the visual and motor cortical zones during orienting reflex and high-frequency stimulation of reticular formation nuclei (NRP and NRT) is of the same type. The synchroneity in the activity of motor zone layers and the fifth layers of different areas increases in parallel. At the same time in the spectra of layer activity high-coherence theta-rhythm increases simultaneously. The data obtained permit to assume that specific rearrangement in the synchroneity of biopotentials of the studied layers during orientation reflex is due to influences of the reticular formation. The effect of mammillary bodies stimulation proved to be less effective.

Animals↗
PubMedDate not supplied

[The behavioral and biochemical sequelae of the removal of the olfactory bulbs in C57Bl/6j mice].

Ablation of the olfactory bulbs in mice C57Bl/6j was accompanied by motor and orienting-exploratory activity augmentation in the "open field" test and deterioration of the learning ability to active and passive avoidance. The most expressed behavioural changes developed in four weeks after the surgery. Chronic administration of antidepressants (amitriptyline, 20 mg/kg; trazodone, 20 mg/kg; imipramine, 10 mg/kg; intraperitoneally) normalized behaviour of bulbectomized animals, trazodone being the most effective. In the biochemical studies the brainstem serotonin level was found to be decreased and the density of 5HT2-receptors in the cerebral cortex increased in bulbectomized mice. Only trazodone was able to correct the biochemical indices. The state of the bulbectomized mice is supposed to serve a model of a depression with hypo-function of serotonergic system of the brain.

Amitriptyline↗
PubMedDate not supplied

[Effect of the local administration of 5,7-DHT and 6-OHDA into the neocortex on the learning and exploratory behavior of rats in an open field].

On Wistar rats characteristics were studied of investigating behaviour in the open field, of learning of conditioned food-reinforced reaction and also of BA and their metabolites content in various brain structures under local intracerebral injections of specific neurotoxins; 6-hydroxydopamine (6-OHDA) and 5,7-dihydroxytryptamine (5,7-DHT), abolishing correspondingly catecholaminergic and serotoninergic terminals. Bilateral injection of 6-OHDA in the neocortex led to a weakening of rats investigating activity in the open field and to an increase of the time of fulfillment of the forming of conditioned food-reinforced reaction. Administration of 5,7-DHT was accompanied by an increase of the investigating behaviour in the open field and a reduction of the duration of the forming of conditioned reaction. Administration of 6-OHDA to the neocortex caused a lowering of catecholamines level in the frontal area of the neocortex and the hippocampus. Analogous administration of 5,7-DHT elicited simultaneously with a deep level lowering of 5-HT and its metabolite in these structures, a change of catecholamines content which testifies to a lesser specificity of the neurotoxin 5,7-DHT in comparison with 6-OHDA. Structures lesion of serotoninergic and catecholaminergic systems of the frontal cortex and the hippocampus brought about by a local administration of 6-OHDA and 5,7-DHT in the neocortex was accompanied by differently directed changes in animals behaviour.

5,7-Dihydroxytryptamine↗
PubMedDate not supplied

[Effect of coagulation of the reticular formation in the region of the NRP and NRT nuclei on the spread of brain biopotential synchronization in rabbits].

The influence of coagulation of NRP and NRT nuclei on the level of spatial synchronization of bioelectrical activity in the visual and motor cortical areas was studied in chronic experiments on alert rabbits. It was shown that elimination of these structures from activity diminishes the correlation of processes in the studied zones. The degree of the coagulation effect depends on the volume of destruction and on the degree of synchroneity of the background neocortical biopotentials. Destruction of the nuclei is attended with dominance of delta-frequencies in the power spectra and a drop of coherence function in the theta range. It is assumed that the NRP and NRT nuclei are functional links of the integral system which controls the level of spatial synchronization of bioelectrical processes in the rabbit cerebral cortex.

Animals↗
PubMedDate not supplied

[Origin of the electroencephalogram].

An attempt is made to estimate the contribution of the activity of each cortical layer of rabbit's brain and subcortical structure in EEG formation. It has been shown that the main generator layers of spontaneous EEG are the I layer--the layer of apical dendrites and the V--the layer of pyramidal neuron somas. To perform a quantitative estimation of passive penetration of the electric fields from deep-seated structures, chiefly from the hippocampus, biopotentials studied were recorded from I, V cortex layers and hippocampus simultaneously, the cortex being disengaged by the method of propagating depression. Significant suppression of surface-activity of the motor cortex was achieved with its preservation in the hippocampus.

Animals↗