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N V Emel'ianova

Publications and source records attributed to N V Emel'ianova.

6 recordsLinked to original sources
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[The effect of Yersinia pestis antigens and strains on the level of lymphocyte blast transformation].

Lymphocytic blast-cell transformation (LBCT) is shown to be related both to the genotype of a macroorganism and to the genetically determined expression of individual antigens by the plague microbe. The correlation of LBCT with the level of antiinfectious resistance suggests that this index is of high informative value and that it can be effectively used for testing the cellular immunity and the characteristically biological properties of the plague causative agent and its antigens.

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PubMedDate not supplied

[Effect of preparations of protein Yop encoded by Yersinia pestis calcium-dependence plasmid on mice].

The impact of the preparations of Y. pestis secreted proteins Yop (YopH-M, YopB, YopD-N, YopE) on mice immunized with 3 s.c. injections was studied. Though these proteins failed to protect the animals from plague, they stimulated the immunobiological transformation in the immunized animals. YopB and YopD-N were found to have the highest immunobiological activity with respect to mice. The preparation of YopB induced the production of the highest titers of specific antibodies and stimulated cell-mediated immune response. The injection of YopD-N to mice led to a considerable decrease in the proliferative capacity of splenocytes in vitro in response to stimulation with nonspecific mitogen ConA, as well as to pathological changes in the kidneys.

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PubMedDate not supplied

[Interleukin-1 induction by different antigens and strains of Yersinia pestis bacteria in immunized mice].

In this work the influence of Y. pestis antigens (capsular antigen, mouse toxin, lipopolysaccharide, pesticin), as well as the products of gene expression localized on three Y. pestis resident plasmids, have been studied. Capsular antigen and some antigens coded for by plasmid pCad have been shown to possess essential activity in the initiation of the synthesis of interleukin-1. Mouse toxin and the products of plasmid pPst produce the opposite effect.

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