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Biomedical subjects

N V Ermakova

Publications and source records attributed to N V Ermakova.

13 recordsLinked to original sources
PubMed2004

[Antitumor effect of natural avermectins].

The effects of the natural avermectin complex, aversectin C and individual avermectin B1 on the growth of ascitic and solid transplantable tumors in animals were studied. The results showed for the first time that both aversectin C and avermectin B1 possessed marked antitumor activity. In subtoxic doses aversectin C significantly inhibited the growth of P388 lymphoid leukemia and Ehrlich carcinoma, both ascitic and solid ones. In some administration regimens aversectin C inhibited the tumor growth by 70 to 80%. The highest effect of aversectin C was observed after its intraperitoneal administration. Avermectin B1 inhibited the growth of solid Ehrlich carcinoma and carcinoma 755.

Administration, Oral↗
PubMed2004

[Modification of antitumor effect of vincristine by natural avermectins].

The effect of avermectins (aversectin C, aversectin C1 and avermectin B1) on the vincristine antitumor action with respect to murine transplantable tumors was studied. It was shown that both the natural avermectins mixtures and the individual avermectin B1 potentiated the antitumor action of vincristine on Ehrlich carcinoma, melanoma B16 and P388 lymphoid leukemia, including the vincristine resistant strain P388. Such an effect of the avermectins was observed only when they were administered after vincristine.

Animals↗
PubMed2003

Combined action of doxorubicin and gestagens on doxorubicin-sensitive and doxorubicin-resistant MCF-7 cells.

The combined cytostatic effect of doxorubicin and gestagens progesterone, medroxyprogesterone acetate, mecigestone, and butagest on doxorubicin-resistant and doxorubicin-sensitive human breast cancer MCF-7 cells was studied by the MTT assay. On the 6th day of incubation progesterone, medroxyprogesterone acetate, mecigestone, and butagest in high concentrations (10(-5) M) potentiated the cytostatic action of doxorubicin in sensitive and resistant cells by 30-50%. Potentiation of the cytostatic effect produced by doxorubicin in sensitive cells is related to intrinsic cytotoxic activity of gestagens. In resistant cells these changes are associated with potentiation of the effect of doxorubicin.

Antibiotics, Antineoplastic↗
PubMed2003

[Adaptive reactions of students from mountain and plain regions of Latin America to conditions of middle Russia].

This article contains results of the comparative study of the functional state of respiratory and cardiovascular systems of almost healthy students (man) of age 19-22, inhabitants of mountain and plain regions of Latin America during their adaptation to the conditions of middle Russia. We have established that there are reliable distinctions in the functional state of cardio-respiratory system of students from mountain and plain regions of Latin America. So for representatives of mountain regions of LA were typical higher indicators of vital capacity, permeability of large and medium bronchial tubes, stroke volume, lower indicators of heart rate, systolic arterial pressure, myocard tension index, but higher coefficient of myocard efficiency than for inhabitants the plain. Considerable distinctions have been observed also in the intercommunication between different indicators. There have been marked considerable correlation connections between small bronchial tubes permeability and cardiovascular system indicators for plain inhabitants. For mountain regions inhabitants almost every indicator of bronchial tubes permeability correlate reliably with vital capacity, but didn't correlate with hemodynamics indicators.

Adaptation, Physiological↗
PubMed2001

[Specific aspects of hemostasis and lipid peroxidation in thrombocyte membranes during expedition and shift organization of labor].

The aim of the present study is to investigate dynamics of the hemostasis system and structural and functional state of thrombocyte membranes by the LPO and AOD parameters under the conditions of expedition and shift organization of labour of worker tripping from the West Siberia middle latitudes to the Far North. A trend to hypocoagulemia and increases in LPO and AOD reactions were characteristic of the type-1 (adaptive) reaction. The type-2 (hypotensive) reaction included a trend to hypercoagulemia, an increase in LPO and a decrease in AOD reactions in thrombocyte membranes as well as a hypertensive reaction during the whole shift period. The type-3 (asthenic) reaction was described by hypocoagulemia, an increase in the amount of LPO products with a simultaneous decrease in the AOD activity and asthenic sleep disturbance.

Adult↗
PubMed1995

[Ecology, adaptation and biorhythms].

The interfusion of environmentology and chronobiology makes it possible to explore various physiological mechanisms which arose in the process of evolution as a response to the external challenges. Therefore, a living organism adapts to a changing situation on the environmental and evolutional time scale. Since the temporal structure of environment is rhythmic by nature, body parameters may be strongly dependent on the environmental factors during adaptation. Results of the in-depth environmental and physiological studies of representatives of different climatic-geographical regions pointed to a series of common and individual properties of the human body reaction to an environment. The combination of hypoxia and hypercapnia (rebreathing test) brought into light a relationship of the reciprocal reaction of respiration and circulation to the body mass index and the average annual temperature in a region. The higher the temperature, the lower the body mass index, the weaker the hemodynamic reaction and the more expressed the ventilatory reaction.

Adaptation, Physiological↗
PubMed1995

[Comparative study of adaptive responses of the cardiorespiratory system in inhabitants of different climatic-geographic regions].

The paper reports the data of comparative study of the cardiorespiratory function in healthy males (19-22 year old) from the countries in Asia, Africa, and Latin America lying within the tropic climatic-geographical zone during acute adaptation to the nature and the climate of the middle zone of Russia. The distinctions in respiration, circulation and gas exchange functions in the natives of different climatic-geographical zones were found as during comparative rest so under the combined effects of hypoxia and hypercapnia induced by the rebreathing test and ascribed to the environmental-genetic constitutional properties of the body and the chronobiological characteristics of the place of abode. Reactivity to the combined effects of hypoxia and hypercapnia in different groups is predominantly a function of unequal contributions of hemodynamics and pulmonary ventilation. A relatively low effectiveness of the cardiorespiratory system in representatives of the South-East Asia during acute adaptation was established. These results demonstrate the benefits of the hypoxic-hypercapnic test for determining functional potentials of the cardiorespiratory system in the context of adaptation to a new environment.

Adaptation, Physiological↗
PubMedDate not supplied

[Influence of sodium salicylate, acetylsalicylate, 2, 3-dihydroxybenzoic and 2, 3-diacetoxybenzoic acids on the blood coagulation system and the elimination of heparin].

Tests conducted on rabbits demonstrated that with a long-term enteral introduction (in amounts of 200 mg/kg, twice a day for 10 days) of 2-3-diacetoxybenzoic acid, sodium salicylate and acetylsalicylic acid these compounds depress the coagulation potential of the blood, 2-3-diacetoxybenzoic acid displaying also a hypocoagulation action even with its single administration in a dose of 400 mg/KJI. The said substances raise the level of the endogenous blood heparin and reinforce the anticoagulative action of heparin, 2-3-dioxybenzoic acid lowers somewhat the concentration and the anticlotting effect of heparin.

Animals↗