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Biomedical subjects

N V Karaman

Publications and source records attributed to N V Karaman.

At least 19 recordsLinked to original sources
PubMed2004

[A role of activation of proinflammatory cytokines and production of autoimmune complexes in the pathogenesis of chronic heart failure in patients with postinfarct cardiac dysfunction].

A comparative randomized clinical study was conducted to evaluate the diagnostic and prognostic value of the activation of proinflammatory cytokines [tumor necrosis factor-alpha (TNF-alpha), interleukin (IL)-1alpha, IL-2, IL-6, IL-8)] and the increased production of autoimmune complexes in the pathogenesis of chronic heart failure (CHF) in patients with coronary heart disease (CHD). The study included 47 patients with CHD who had a more than 6-month history of Q-forming myocardial infarction. The patients were randomized into 3 groups: 1) 21 patients with NYHA Functional Class (FC) II heart failure (HF); 2) 16 patients with FC III HF; and 3) 10 with FC IV HF. Basic therapy involved angiotensin-converting enzyme (ACE) inhibitors, nitrates, diuretics, beta-adrenoblockers; 27.6% received digoxin, disaggregatory agents. A study protocol involved the estimation of the parameters of EchCG, paired bicycle ergometric tests, 6-min walking test, ECG daily monitoring, the levels of proinflammatory cytokines in the serum and IgG autoantibodies to cardiolipin. The findings suggest that with the higher expression of autoimmune complexes, the activation of cytokines (primarily TNF-alpha, IL-1alpha, IL-2) plays an important role in the pathogenesis of CHF in patients with postinfarct cardiac dysfunction: the high activation of cytokines and the elevated level of autoimmune complexes are associated with moderate or severe NYHA FC II-IV HF, depressed left ventricular contractility (ejection fraction, 23-38%), low exercise tolerance, and cardiac remodeling.

Adrenergic beta-Antagonists↗
PubMed2004

[Effect of carvedilol on blood levels of cytokines and symptoms of heart failure in patients with postinfarction cardiac dysfunction.].

Effect of 6 months treatment with carvedilol (25 mg/day) on blood levels of cytokines (interleukins 1alpha, 2, 6, 8, tumor necrosis factor alpha) and clinical symptoms of heart failure was studied in patients with cardiac dysfunction after myocardial infarction. Patients with NYHA class II heart failure, ejection fraction 50% and moderately lowered tolerance to physical exercise (n=21) initially had enhanced cytokine expression: blood content of interleukin (IL) 2 was 2.8 times, tumor necrosis factor (TNFalpha) 78%, IL-1alpha 60% above normal level. Therapy with carvedilol in this group was associated with decreases of Il-2 (-23.8%), TNFalpha (-16.7%), IL-1alpha (-12.5%) (p<0.05-0.01). This was accompanied by alleviation of clinical symptoms and improved exercise tolerance. Patients with NYHA class III heart failure (n=16) with low left ventricular ejection fraction (30+/-2.7%) and low exercise tolerance had high levels of all studied cytokines. Levels of IL-2, TNFalpha and IL-1alpha were most elevated (3.1, 2.8 and 2 times higher than normal values, respectively). Therapy with carvedilol was associated with improvement of clinical symptoms and exercise tolerance (+35%, p<0.05)), increase of ejection fraction (+15%, p<0.05), decrease of left ventricular end systolic volume (-17.5%, p<0.05), and lowering of blood levels of TNFalpha (-31%), IL-2 (-17.4%), IL-1alpha (-15.6%). However cytokine levels remained substantially elevated compared with normal values. Carvedilol was well tolerated, and did not cause negative metabolic effects or other complications.

Adrenergic beta-Antagonists↗
PubMed1990

[Emergency laparoscopy in the diagnosis of closed abdominal trauma].

Analysed were the 242 case records of the sufferers treated for closed abdominal trauma. In 80, the laparocentesis was performed with the use of the "seeking catheter", in 78--combined laparoscopy. The indications for the performance of these diagnostic manipulations are substantiated, their diagnostic informative value is assessed.

Abdominal Injuries↗
PubMed1989

[Diagnosis and treatment of pylephlebitis of appendicular origin].

Under observation there were 11 patients with destructive appendicitis complicated by pylephlebitis. Early antibiotic treatment using antibiotics of reserve under control of antibioticogram, introduction of metronidazole++, heparin and adequate desintoxicating therapy allows to anticipate successful results. The best results in shorter terms can be achieved by the intraportal administration of antibiotics, heparin and other drugs after recanalization and catheterization of the umbilical vein.

Acute Disease↗
PubMed1982

[Humoral factors of nonspecific reactivity of the body in peritonitis].

Humoral factors of inflammation such as histamin, heparin and others are known to play an important role in pathogenesis of peritonitis. Their intimate interrelations in the metabolism are responsible for the degree of the nonspecific defense reaction of the organism with this disease. The recovery of the humoral-tissue regulation of homeostasis goes on slowly against the background of inhibition of the nonspecific reactivity of the organism despite a liquidation of the source of peritonitis.

Antibody Formation↗
PubMed1980

[Causes of mortality in acute appendicitis].

Cause of lethal outcomes of acute appendicitis were studied. Operations were performed in 11162 cases. Fourty eight patients (0,43%) died. In addition, 7 patients died without an operation. In 65% of dead patients diagnostic, technical and tactical errors were stated. Among their causes were the following: late admission to the hospital resulting in the appearance of complications which masked the main disease, groundless extension of indications for the operation, absence of individual operative measures and methods depending on the specific features of the pathological state.

Acute Disease↗