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Biomedical subjects

N V Kozlova

Publications and source records attributed to N V Kozlova.

At least 19 recordsLinked to original sources
PubMed1994

[State of vaginal microbiocenosis and its correction in pregnant women living under conditions of constant exposure to low doses of radiation].

Microflora of the vaginal mucosa was investigated bacteriologically in 44 pregnant women at the pregnancy term of 27-28 weeks. It was shown that in half of the women the vaginal microbiocenosis was within the normal and did not depend on urogynecological diseases in the case histories. In the women with impaired microbiocenosis the level of the impairment depended on gynecological diseases in the case histories. In the pregnant women without urogynecological diseases only slightly pronounced changes in the vaginal microbiocenosis were detected. The prophylactic use of eubiotics (bifidumbacterin and lactobacterin) was not efficient. In the women with urogynecological diseases in the case histories the levels of the microbiocenosis impairment were different. The prophylactic use of the eubiotics was efficient when the changes in the vaginal microbiocenosis were slightly pronounced or marked. When the changes were extreme the prophylactic use of the eubiotics failed.

Adult↗
PubMed1994

[State of intestinal microbiocenosis and its correction in pregnancy women living under conditions of increased radiation pollution].

The contents of the large intestine were investigated bacteriologically in 44 pregnant women at the pregnancy term of 27-28 weeks living in the areas contaminated with radionuclides at a concentration of 15-40 C/km2. It was found that in 9.6 per cent of the women the intestinal microbiocenosis was within the normal and in 19.1 per cent there was detected marked dysbacteriosis. In the other women compensated or subcompensated intestinal dysbacteriosis was recorded. The state of the large intestine microbiocenosis in the pregnant women did not depend on urogynecological or infectious diseases in the case histories. The prophylactic treatment with eubiotics (bifidumbacterin per rectum and lactobacterin intravaginally) aimed at the correction of the impaired microbiocenosis had a favourable effect which did not depend on urogynecological or infectious diseases in the case histories. After the completion of the prophylaxis course with the eubiotics some indices improved but the percentage of the pregnant women isolating colibacilli with the properties of virulence increased.

Anti-Bacterial Agents↗
PubMed1990

[Streptonigron--a minor component of bruneomycin complex].

A mutant strain of the bruneomycin-producing culture which produced up to 10% of the minor component was selected. The component was identified as streptonigrone. It was isolated and its physicochemical properties and antibacterial activity were investigated. Trimethylsilyl derivatives of streptonigrone and bruneomycin were prepared. Their PMR spectra and electron impulse mass spectra were studied. Streptonigrone was shown to have antibacterial and cytotoxic activities which was 1 to 2 orders of magnitude lower than that of bruneomycin.

Bacillus↗
PubMed1990

[Ways of improving the effectiveness of bacteriological diagnosis and treatment of nonspecific lung diseases].

Isolation, identification and drug sensitivity assay of microorganisms from pathological materials of 177 patients with nonspecific diseases of the lungs, mainly pneumonia, were performed on blood and selective "chocolate" agars by using Baktofok-MK, a new dry nutrient basis developed by the authors. Blood and "chocolate" agars based on the Hottinger's hydrolysate were used as the control media. It was shown that with the quantitative procedure for inoculating the pathological material, the experimental media based on Baktofok-MK were much more sensitive to growth properties that the control media. That made it possible to detect larger numbers of etiologically important microbial species on the blood agar and to isolate clinical strains of Hemophilus spp. from a larger number of specimens on the "chocolate" agar.

Agar↗
PubMed1989

["Chimeric" antibiotics, daunorubicin and its analogs N-acylated with bruneomycin (Streptonigrin)].

Anthracycline antibiotics (daunorubicin, carminomycin and doxorubicin) N-acylated with antibiotic bruneomycin (streptonigrin) have been obtained from the parent compounds upon treatment with N, N'-dicyclohexylcarbodiimide and N-hydroxysuccinimide. These "chimeric" antibiotics are less active both in vitro and in vivo than the parent antibiotics. This demonstrates the stability of the intermolecular amide linkage in these compounds towards chemical and enzymatic hydrolysis as well as their inability to interact with corresponding receptors in contrast to less hindered derivatives of the parent antibiotics.

Acylation↗
PubMed1985

[Blood serum creatine kinase in diseases of the cardiovascular system].

Serum creatine-kinase activity was above the upper normal limit in 40-80% of the 632 patients admitted to hospital for angina pectoris and deteriorating essential hypertension. The highest (4-6-fold) increase over the mean control values was associated with myocardial ischemia, paroxysmal tachycardia and hypertensive crises. Intramuscular injections were shown to be unrelated to increased incidence or magnitude of creatine-kinase activation in the examined patients. Creatine-kinase levels were particularly high in cases of cerebral stroke (a 7-fold increase above normal) and alcoholic cardiopathies (a 8-fold increase).

Angina Pectoris↗
PubMed1976

[Experimental and clinical study test of capreomycin].

Data on the experimental and clinical study of capreomycin in the treatment of tuberculosis are presented. It was shown that capreomycin had low activity with respect to the sensitive strain of Mycobacterium tuberculosis H37 Rv in vitro and the respective infection caused by it in mice. The activity of capreomycin in vitro with respect to streptomycin resistant strains was the same as that with respect to the sensitive strains, while in vivo it increased 3 times. Capreomycin showed a tendency to decreasing its activity with respect to strains highely resistant to canamycin only in vitro. The effect of capreomycin on tuberculosis infection caused by strains resistant to different concentrations of canamycin was the same as that on tuberculosis infection caused by sensitive strains. Cross resistance between florimycin (viomycin) and capreomycin was shown. Clinical trails of capreomycin revealed its moderate therapeutic efficiency, relatively low toxicity and an allergenizing effect on the host. Transient ventibulopatia without pronounced signs of ototoxic action was observed. The nephrotoxic effect was moderate and transient. It was observed predominantly at the peak of the allergic reactions to the antitubercle drugs. The data obtained during the study allow recommendation of capreomycin use in clinics as reserve drug when the causative agent is not resistant to florimycin. The drug should be used under regular control of the blood picture, electrolyte metabolism, state of the kidneys, auditory and vestibular apparatus.

Adult↗