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Biomedical subjects

N V Larin

Publications and source records attributed to N V Larin.

7 recordsLinked to original sources
PubMed1996

[Methods for diagnosing the physiopathological mechanisms of bronchial obstruction].

This study aimed at clarification of pathophysiological mechanisms underlying bronchial obstruction in 28 18-71-year-old patients with chronic bronchitis (CB) diagnosed 2-8 years before. The patients had moderate obstructive disorders in distal parts of the bronchial tree. Investigations revealed a group of patients with paradoxical response to beta-blockers manifesting as lowering of bronchial resistance and high speed. Bronchial obstruction in these patients proved to arise primarily from early expiratory collapse of small bronchi. Administration of beta-mimetic and beta-blocking agents may serve as pharmacological tests able to discover mechanisms of bronchial obstruction and help in the choice of adequate therapy for chronic bronchitis.

Adolescent↗
PubMed1984

[Detection of latent hemodynamic disorders of the lesser circulation in patients with chronic obstructive bronchitis and bronchial asthma].

Thirty-three patients with infectious allergic bronchial asthma and chronic obstructive bronchitis and 47 normal subjects were examined with the aid of a complex of bloodless research methods for the pulmonary circulation and central hemodynamics under graded physical exercise of minor power. Investigation at rest did not disclose any hemodynamic disorders in the greater and pulmonary circulation. Application of bicycle ergometry to patients with chronic obstructive bronchitis and bronchial asthma in a stage of remission made it possible to reveal latent hemodynamic disorders of the pulmonary circulation that manifested by long-term elevation of the pressure in the pulmonary artery and pulmonary vascular resistance, restitution of the central hemodynamics according to the hyperkinetic type. The use of the generally accepted formulas for calculating the proper magnitudes of the ejection period and mechanical systole with the heart rate exceeding 90 per minute resulted in overdiagnosis of the overload of the right ventricle. The authors offer the regression equations for calculating these parameters during tachycardia.

Adult↗