Biomedical subjects
Publications and source records attributed to N V Mokeeva.
Increasing of the allergization of the population in industrial regions caused by chemical pollution of the air was noted. Some changes in respiratory tract and blood count were reported also.
In the mycological study of the air in working rooms at enterprises for the production of paprin and in the airspace of residential areas, as well as the study of the fungal contamination of the upper respiratory ways in workers and residents of the development zone, the isolation rate of the production fungal strains of the genus Candida from the nasopharynx was shown to depend on their content in the air. In the absence of producer microorganisms in the atmospheric air they were not detected among the population. The detection of yeast-like fungi of the genus Candida on the pharyngeal mucosa is of sanitary demonstrative importance for the evaluation of the specific microbial contamination of the air in working rooms and the air space of the development zone. When the stable work of gas purification systems was ensured at modern enterprises for the production of protein vitamin concentrate no production strains were detected in the atmospheric air of the development zone and on the nasopharyngeal mucosa of the residents, which was indicative of the absence of any influence of gas and air discharges from these enterprises on the microbial contamination of the airspace.
In the dynamic survey of 577 persons having had contacts with yeast-like fungi of the genus Candida the effectiveness of tests for the diagnosis of mycogenic sensitization was made with the use of a number of immunological methods. The basophil degranulation test was shown to have higher sensitivity and specificity in the detection of hypersensitivity to microbial strains used in the production processes of microbiological synthesis, while the use of polysaccharide antigens is more expedient in immunological reactions, such as the precipitation test with the finished product obtained by these processes and with C. albicans. Some prevalence of the level of sensitization in the presence of Candida carriership was established in persons having had contacts with these fungi.
The efficacy of environmental protection in the areas of location of protein synthesis microbiologic plants was analyzed. It was established that under the conditions of observance of a technological regime and the stability of the gas cleaning systems for industrial affluents the operation of the plants caused no air pollution of residential districts by fungi producers and protein dust of the finished product. The study revealed the absence of detrimental health effect of microbiologic products. The proposed set of biomedical indicators can be recommended for monitoring air quality in the area of location of microbiologic plants.
The study of 106 pregnant women engaged in microbiological synthesis production revealed the tendency to increasing genitalia contamination by Candida yeast-like fungi, including fungi-protein producers, and also oppression of immunologic reactivity in comparison with nonpregnant women and the control group. It was pointed out that from the beginning of their pregnancy period women should have no contact with yeast-like fungi.
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