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Biomedical subjects

N V Ol'shanskaia

Publications and source records attributed to N V Ol'shanskaia.

12 recordsLinked to original sources
PubMed1982

[Immunogenicity of leukemic cells during low-temperature freezing with different cryoprotectors].

Immunogenicity of leukemic cells was studied and compared during conservation with the three cryoprotectors, DMSO, DMAC, and PEO. Immunogenicity of leukemic cells was assessed from immune response of the experimental animals to immunization with these cells (the titer of cytotoxic antibodies and lymphocyte cytotoxicity). The data obtained indicate that immunogenicity of leukemic cells conserved with DMAC and PEO does not virtually differ from that of native cells or of cells conserved with DMSO.

Animals↗
PubMed1977

[Effect of interferon on the immune response of mice to immunization with the cells of transplantable leukemias and sarkomas].

The treatment of cells L-1210 and MX-11 in vitro with interferon, prior to their injection to mice, caused an enhancement of specific humoral response and cytotoxic action of immune lymphocytes to Cr51 labelled target cells. The injecting of mice with allogeneic interferon-containing serum against the background of immunization with L-1210 cells produces an enhancing effect upon the immune response. Much more marked enhancing effect was observed when using syngeneic interferon-containing serum. Short-term treatment of lymphocytes, being immune to L-1210 cells, with interferon in vitro leads to the increase of their specific cytotoxicity to Cr51 labelled cells. Pre-treatment of leukemic cells with interferon would enhance their sensitivity to specific antibodies. It is suggested to use an active immunization of acute leukemia patients with allogeneic leukemic cells pre-incubated in interferon in combination with the injection of interferon-containing donor plasma.

Animals↗
PubMed1976

[Intensification of cellular immune response by immunization of mice with the cells preincubated in interferon].

Mice F1(CBA X C57BL/6) were immunized intraperitoneally with a single injection of L-1210 cells preincubated in interferon or control "false" preparation. CBA mice were injected with MX-11 cells: similarly treated according to the same scheme. Injection of interferon-treated cells was accompanied by the enhancement of the cellular immune response. The greatest cytotoxic activity was possessed by the lymphocytes of mice to which M-11 cells were administered together with interferon in which the cells were formerly incubated.

Animals↗
PubMedDate not supplied

[Nature of the interferon circulating in the blood of bronchial asthma patients].

For the elucidation of the nature of interferon circulating in the blood of patients with bronchial asthma in the period of exacerbation the sensitivity of the collected samples to pH 2.0 and 56 degrees C was determined and neutralization test with interferon anti-gamma-serum performed. All the 17 specimens under study were found to contain a mixed population of interferon presented mainly by the gamma-type (greater than or equal to 75%). The remaining amount of interferon (less than or equal to 25%) consisted of alpha- and/or beta-type. The prognostic value of the data obtained is discussed.

Antigens↗
PubMedDate not supplied

[Immune system indices in diabetes mellitus].

The immunological indices were studied in 24 patients with diabetes mellitus: 11 with insulin-dependent type (IDD) and 13 with insulin-independent type (IID). In the IDD patients sensitization to commercial insulin and bacterial allergens was more common in vitro than that in the IID patients. The per cent content of T-lymphocytes and an absolute number of phagocytic cells decreased in the peripheral blood of the IDD and IID patients. Both forms of diabetes mellitus were accompanied by disglobulinemia with an elevated serum immunoglobulin A level and a decreased immunoglobulin G content.

Adult↗