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Biomedical subjects

N V Pizova

Publications and source records attributed to N V Pizova.

12 recordsLinked to original sources
PubMed2005

[Magnetic-resonance angiography in systemic lupus erythematosus].

Magnetic-resonance angiography (MRA) is an informative non-invasive method in assessment of cerebral circulation. The aim of the study was to investigate cerebral circulation in systemic lupus erythematosus in the dynamics of the pathological process using MRA data. The complex investigation revealed different changes of cerebral circulation which depended on the activity and course of the immunological process.

Adult↗
PubMed2005

[Syndromes of peripheral nervous system lesions and mechanisms of their formation in disorders of connective tissue].

Systemic rheumatoid diseases are often concomitant with the development of central and peripheral systems pathologies. Presented are the results revealing high frequency of peripheral nervous system lesions (lupus erythematosus and systemic scleroderma), which characterized by polyneuropathy and tunnel syndromes. Based on the results of literature and own studies, pathological mechanisms of peripheral nervous system lesions in diffusion disorders of connective tissue were singled out as follows: ischemic, immunological and metabolic. Taking these mechanisms into account will permit to conduct pathogenetically valid therapy and to improve its results.

Connective Tissue Diseases↗
PubMed2004

[Cerebral vascular pathology in systemic sclerosis].

Thirty patients with systemic sclerosis (SS), aged 20-55 years, illness duration 1-10 years, were observed. Vasospastic syndrome of different expression predominated in the clinical picture of the disease. Among neurological signs, prevalent were peripheral nervous system lesion--isolated (20% of the cases) or in combination with chronic insufficiency of brain circulation (80%). Vascular pathology was distinctly determined by ophthalmoscopy: angiopathy was found in 42% of the patients, angiospasm--in 25%, angiosclerosis--in 17%. The following types of disorders characterized brain blood flow: distonic (42%), dyscirculatory (33%), normotonic (17%), hypotonic (8%). Besides, 83% of the patients had hemispheric asymmetry of blood flow and difficulties with venous outflow. In some cases, the signs of inner, external and combined hydrocephalia were determined by CT and MRI; more than a half of the patients had dilatation or deformation of brain ventricular system with intracranial hypertension. The data obtained suggest that extra- and intracranial blood flow pathology in SS may, to a large extent, determine both organic brain lesion development in general and the genesis of many symptoms (headaches, vestibular disorders, etc).

Adult↗
PubMed2004

[Differential diagnosis of multiple sclerosis and systemic vasculitis].

Two groups, each included 12 patients, with confirmed diagnosis of multiple sclerosis (age 19-35 years) and with systemic vasculitis (age 21-47 years) were compared in the study. Differential clinical immunological and tomographical features of these two states are described.

Biomarkers↗
PubMed2004

[Systemic vasculitis as an interdisciplinary problem].

Systemic vasculitis (SV) is characterized by generalized vascular bed lesion involving vessels of different sizes into a pathological process. The paper presents the results of a follow-up of 500 patients with different forms of SV, by making studies of immunity and the hemostatic system, angioscanning, Doppler ultrasound study of vessels, electrophysiological studies (rheoencephalography, encephalography), computed and magnetic resonance imaging of the brain, and visceral ultrasonography. A variety of clinical symptoms and involvement of different organs determine the interest of physicians of different specialties in the diagnosis and treatment of SV. The involvement of the nervous system in the process occurs in all forms of vasculitis, by afflicting the central, peripheral, and autonomic nervous systems with the development of regulatory and functional disorders. Lesions of the visual organ are typical of nonspecific aortoarteritis (Takayasu's disease), Wegener's granulomatosis, giant-cell arteritis. Recurrent uveitis is characterized in Behcet's syndrome. Cutaneous manifestations are included into the classification criteria of nodal polyartheritis, hemorrhagic vasculitis, and Kawasaki's disease. ENT and oral involvement are observed in Wegener's granulomatosis.

Arterial Occlusive Diseases↗
PubMed2002

[Antiphospholipid syndrome and multiple sclerosis: differential-diagnostic aspects].

A comparative study of 5 patients with definite multiple sclerosis who have abnormally high titer of anticardiolipin IgG-antibodies [MS aCL(+)] and 9 patients with antiphospholipid syndrome (APS) aged 22-43 was carried out. The results of this study are reported. The investigation has shown that some clinical and magnetic resonance imaging (MRI) sings in patients with APS imitate the course of MS. This situation makes differentiation of two conditions quite difficult. The peculiarities of course of MS aCL(+) such as progressive myelitic pattern, nontypical for MS articular, cutaneous (livedo, ecchymoses) and vasospastic lesions have been shown. The differential diagnostic clinical, immunological and MRI-criteria of two diseases have been found out. The investigation reveals that APS has not only cerebrovascular manifestation but polyneuropathy (in preference of demyelinating type) and autoimmune myopathy.

Adult↗
PubMed2002

[Acute disturbances of cerebral blood flow in systemic lupus erythematosus].

Seventy-four patients with systemic lupus erythematosus were studied using a complex clinico-neurological and instrumental examination. Frequency of main syndromes was estimated. Characteristic features of acute cerebrovascular pathology development and risk factors for stroke in patients with systemic lupus erythematosus are presented.

Adult↗
PubMed2001

[Stroke in rheumatic disease: risk factors].

The aim of this paper is to detect stroke risk factors in rheumatic diseases. The authors performed clinical and neurological investigations using MRI and CT tomography, ultrasound dopplerography, electrophysiological (reoencephalography, electroencephalography) techniques in 233 patients with rheumatic diseases. 197 patients (84.5%) presented cerebro-vascular disease, 93 (39.9%) of them had stroke. We divided all patients into two groups: group 1 included patients with "stroke at onset" (19%) and group 2 included patients with "delayed stroke" (21%). Patients with "stroke at onset" had such risk factors as vascular immune inflammation and unstable arterial hypertension. Patients with "delayed stroke" had such risk factors as hypercholesterolemia, stable arterial hypertension, asymmetric cerebral flow, hypercoagulation and vertebral syndrome.

Antibodies, Anticardiolipin↗