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N V Stepanova

Publications and source records attributed to N V Stepanova.

30 records · Page 2Linked to original sources
PubMedDate not supplied

[Erythropoiesis and osteogenesis (I. The interaction of the reparative processes of bone and hematopoietic tissues)].

The dynamics of erythropoiesis during the bone restoration and under the conditions of perturbing influence: fracture and hemolytic anemia have been studied in the experiment. It is found that under the conditions of callus formation the process of proliferation and differentiation of red cells in the bone marrow is inhibited. The observed effect of erythropoiesis inhibition may be caused by the intercellular interaction of regenerating tissues in their "struggle" for microphages, which, while being the centre of the erythroid insula secure the maturation of erythroid precursors, and at the same time they can take part in the bone formation process.

Anemia↗
PubMedDate not supplied

[Erythropoiesis and osteogenesis (II. The mechanism of the suppression of erythropoiesis during the reparative process in bone tissue)].

The experiment on rats and mice has shown that the presence of a developing callus in the organism after fracture of the tubular bones inhibits erythropoiesis. Inhibition of erythropoiesis is due to delay of erythropoietin biosynthesis by serotonin. A problem on two-fold serotonin effect is under discussion: on the one hand, serotonin inhibits the erythropoietin formation and delays erythropoiesis, on the other hand, it intensifies the effect of ready erythropoietin on the developing bone marrow erythroid cells.

Anemia↗
PubMedDate not supplied

[Mathematical simulation of the regulation of the size of the lymphoid population in relation to chronic lymphoid leukemia].

A model was constructed of accumulation kinetics of labeled lymphocytes based on the experiments of long-term injection of 3H-thymidine label in vivo into the blood of healthy and suffering from chronic lympholeucosis animals. There was found an essential difference between the coefficients of reproduction and death of cells of the proliferating pool for the normal, initial and advanced stages of the disease. This served as a basis for the creation of the closed non-linear model of autoregulation of lymphoid population size describing different stages of leucosis development.

Animals↗
PubMedDate not supplied

[Mathematical model of the effect of glucocorticoids on the movement and proliferation kinetics of mammalian lymphocytes].

Effect of glucocorticoids on proliferation, death and migration of T-lymphocytes was studied by mathematical methods. A model of the interaction between hormone and thymus T1-lymphocytes is proposed which imitates involution of lymphoid tissue under stress. There were constructed models of migrations of free and radioactive chromium labeled lymphocytes in lymphoid and non-lymphoid organs, blood and lymph at arbitrary concentration of glucocorticoids in the blood. Possible mechanisms of immunodepression due to increased hormone concentrations in the organism are discussed.

Animals↗
PubMedDate not supplied

[Changes in liver function in patients with alimentary obesity combined with cholecystitis as affected by diet therapy].

A study was made of the effect of the reduced diet including a dry protein mixture (DPM) and Ocean paste on radionuclide and clinicobiochemical indicators of the bile in 66 patients with alimentary obesity associated with cholecystitis. The control group received the reduced diet. It was noted that improvement of the patients' general status and reduction of the main clinical disease manifestations were accompanied by liver function improvement that manifested in the normalization of absorption-excretory function of hepatocytes and a more marked and significant increase in the level of the main bile, components in patients given the DPM and Ocean paste. It is concluded that the DPM and Ocean paste should be introduced into the reduced diet, since this favours an increase in the diet biological value and efficacy of the management of alimentary obesity associated with cholecystitis.

Adolescent↗
PubMedDate not supplied

[Parameters of the function of cell distribution by size as related to the study of the mechanism of cell growth].

Distribution function of bacteria-rods according to their sizes is calculated assuming linear growth of cells between the divisions and step-like function of division (the division rate equals zero up to the moment when the cell reaches certain length L, then it has constant value A). An approximate analytical expression for the distribution function is obtained; the parameter L and A are calculated from the condition of best coincidence between the theoretical and experimental curves determined by I. A. Basnakyan and G. P. Dubinina (Mechnikov Research Institute of Virology) for continuous culture of typhoid bacteria.

Animals↗