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Biomedical subjects

N V Strizhova

Publications and source records attributed to N V Strizhova.

At least 19 recordsLinked to original sources

Parameters of cellular immunity in perimenopausal patients with glandular and adenomatous endometrial hyperplasia.

No appreciable disorders of cellular immunity were detected in patients with glandular cystic endometrial hyperplasia. Atypical endometrial hyperplasia was associated with quantitative changes in T lymphocytes and their subpopulations, decreased level of lymphocytes carrying activation antigens, and increased count of natural killers. These changes can be characterized as immunocompensation.

Adult↗

[The ultrasonic diagnosis of intrauterine fetal growth retardation].

A total of 256 pregnant women were examined in pregnancy terms of 19-40 weeks. Besides routine fetometric parameters, the transverse diameter of the cerebellum was measured in the fetuses. This parameter was in good correlation with the gestational age. In 42 cases with small-for-date fetuses the transverse diameter of the cerebellum did not much differ from that in the reference group. Therefore measurement of the transverse diameter of the cerebellum is a truly good method for the assessment of the gestational age, for it is virtually independent of all the pathologic processes in the mother or fetus.

Female↗

[The role of biologically active substances in the pathogenesis of dysfunctional uterine hemorrhage in the climacteric period].

The activities of the blood kallikrein-kinin system components (plasma kallikrein, alpha 1-antitrypsin, alpha 2-macroglobulin), and gonadotropin levels in various phases of the menstrual cycle were measured in 35 women ob various age groups. The same parameters were investigated in 28 women with dysfunctional uterine bleedings of the climacteric period. Phasic changes in the blood kallikrein-kinin system components, closely related to the hormonal status, were revealed over the course of the onto-genesis. Climacteric dysfunctional uterine bleedings were found associated with an elevated activity of the plasma kallikrein, parallelled by a relative insufficiency of the blood plasma inhibitor potential. A relationship between the activities of the blood kallikrein-kinin system components and endometrial function has been revealed. These findings necessitate search for approaches to pharmacologic regulation of the blood kallikrein-kinin system activity and to pathogenetic therapy of the climacteric dysfunctional uterine bleedings.

Adult↗

[Complex evaluation of the feto-placental system in gestosis of different degree of severity].

Comprehensive studies of the fetoplacental system in pregnant women with gestoses of varying severity (n = 260) and in those with normal pregnancy (n = 200), carried out in pregnancy terms of 29 to 41 weeks, have revealed a lowering of the levels of trophoblastic beta-globulin and pregnancy-associated alpha 2-glycoprotein, elevated concentration of pregnancy-associated protein A, a higher incidence of placental types II and III (as evidenced by ultrasonic examination), reduced rate of growth of the fetal biometric parameters and a reduction of fetal systolic output, augmenting with the gestosis severity. A comprehensive assessment of the fetoplacental system permits obtain a more complete picture of the gestosis severity.

Anthropometry↗

[The therapeutic characteristics of massive blood loss in puerperae with gestosis].

A regimen of fluid and transfusion therapy has been developed on the basis of clinical and laboratory evaluation of postresuscitation course and outcomes of parturients with massive blood loss and a history of gestosis. An early introduction and systematic use of proteolytic inhibitors were beneficial. Surgical hemostasis warrants a radical approach and requires ligation of internal abdominal arteries and uterus extirpation.

Acute Disease↗

[Differential approach to cesarean section in current obstetrics].

A survey of cesarean sections performed between 1984 and 1987 has demonstrated a changing pattern of indications for abdominal delivery. An expanded range of indications for cesarean section in cases of breech presentation and maternal gestosis has been shown to reduce significantly perinatal losses. It is demonstrated that indications for vaginal delivery in patients with a uterine scar should be expanded through further search for new methods for the assessment of the scar as well as the improvement of the available ones. Intraoperative administration of antibiotics is a method of choice in preventive antibiotic treatment.

Breech Presentation↗

[Treatment of patients with hypertonic disease with plasmapheresis].

The paper presents a discussion on therapeutic results obtained with plasmapheresis treatment in 16 patients with stage II essential hypertension. Thirty-three comparable patients entered a control group of conventional treatment. The test and control patients with stage II hypertension were examined for time-course changes in T- and B-lymphocytes counts, the activity of the energetic enzymes (alpha-glycerophosphate dehydrogenase, succinic dehydrogenase, lactate dehydrogenase), serum immunoglobulins and circulating immune complex levels. It was established that the standard antihypertensive treatment failed to restore normal parameters of immunity and to favor positive alterations in the activity of the enzymes in the blood lymphocytes, whereas therapeutic plasmapheresis was found to stimulate immunity, especially cellular one. This occurred in line with a rise in the levels of lymphocytic dehydrogenases.

Adolescent↗