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N V Vladeeva

Publications and source records attributed to N V Vladeeva.

7 recordsLinked to original sources
PubMed1988

[Clinico-morphologic and histochemical changes in the neuromuscular apparatus in acute carbophos poisoning].

Clinical analysis of 378 acute cases of Malathion insecticide intoxication and pathological and histochemical investigation of skeletal muscles in 7 autopsied victims of acute poisoning have revealed the pronounced neuromuscular disorders. Generalized paresis and paralysis of muscles were observed in trunk and limbs. Muscular fasciculation, hypotonia and hyporeflexia were also generalized. Multiple foci of muscular fibers necrosis and necrobiosis were found with intermuscular nerves and motor endings degenerated, neuromuscular junctions cholinesterase sharply inactivated.

Accidents, Home↗
PubMed1986

[Localization of binding sites in rat muscles and brain for cobra neurotoxin and serum immunoglobulins from patients with myasthenia].

Using the immunohistochemical technique, it was revealed that serum immunoglobulins of patients with myasthenia gravis (Ig) were irreversibly attached to the myoneuronal connections of the rat intercostal muscles like the marker of the nicotin cholinireceptors--the cobra venom neurotoxin (CT). In addition, Ig differs from CT in the binding to nervous cells of the claustrum and diencephalon reticular formation and with certain cells of the nucleus caudatus and hemispheric cerebral cortex. It is suggested that the autoimmune processes in patients with myasthenia gravis do not only involve myoneuronal connection but also participate in central mechanisms of the disease genesis.

Animals↗
PubMed1978

[Use of potassium ferricyanide in histochemistry].

Karnovsky and Roots offer to use potassium ferricianide for coloured detecting the products of acetylcholine hydrolysis by cholinesterase. The method is based on the reduction of ferricianide to ferrocianide which forms with copper ions, present in the solution, unsoluble ferrocianide. Some properties of ferricianide ion, however, (stability, large size and great hydratation) make it difficult for the substance to penetrate the native cell membranes. The method by Karnovsky and Roots applied to laminated muscular tissue and to the rat nonfixed whole diaphragm, and to the sections from nonfixed tissue of the cat skeletal muscle verifies space isolation of ferricianide from the enzyme localized at the other side of cell membrane.

Animals↗