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Biomedical subjects

N Vasiljević

Publications and source records attributed to N Vasiljević.

6 recordsLinked to original sources
PubMed1998

Evaluation of the nutritional status and tumor characteristics in premenopausal and postmenopausal breast cancer patients.

Evaluation of the nutritional status, fat tissue distribution, and tumor characteristics was carried out in patients with primary breast cancer. The patients were classified into two groups according to their menopause: premenopausal and postmenopausal. Breast cancer prevalence was considerably higher in postmenopausal patients (61%). The patients' nutritional status was shown through the body mass index. Based on this indicator, the patients were characterized as nonobese and obese. In the premenopausal group, there was no significant difference between these categories, whereas the number of obese patients was significantly higher (80%) in the postmenopausal group. The analysis of tumor parameters as related to menopause and body size did not yield any significant differences. However, the estrogen receptor content was significantly higher in postmenopausal patients (p < 0.0001). Distribution of fat tissue of the android type was higher in obese postmenopausal women than in premenopausal ones (77%). The investigation showed that the breast cancer incidence odds are 3.5 times higher in obese postmenopausal than in premenopausal patients.

Adult↗
PubMed1996

Variations in steroid hormone receptor content throughout age and menopausal periods, and menstrual cycle in breast cancer patients.

Variations in steroid hormone receptor contents throughout age and menopausal periods define three breast carcinoma groups: younger premenopausal carcinomas (aged up to 45), middle-aged carcinomas (pre-, peri- and postmenopausal aged 45-59) and older postmenopausal carcinomas (aged over 59). Age-related steroid hormone receptor contents within premenopausal and postmenopausal carcinoma groups are characterized by the important increase of both receptor contents, while menopausal-related steroid hormone receptor contents within middle-aged carcinoma group (aged 45-59) are characterized by the important decrease of progesterone receptor content and estrogen receptor functionality. No variations in steroid hormone receptor contents throughout menstrual cycle within the follicular and the luteal phases were obtained. The important decrease of estrogen receptor content in the mid-cycle phase versus the perimenstrual phase was found. Variations in steroid hormone receptor contents throughout age and menopausal periods, as well as throughout menstrual cycle could not be associated with variations in the blood steroid hormone concentrations. However, important association between steroid hormone receptor contents and the blood steroid hormone concentrations was found within the luteal phase carcinoma group and within older postmenopausal carcinoma group. It is interesting that within carcinoma group with the highest concentration of progesterone, progesterone receptor content increases with an increase of the ratio of estradiol and progesterone blood concentrations, while within carcinoma group with the lowest steroid hormone concentration and the highest content of estrogen receptor content, estrogen receptor content decreases with an increase of either the blood estradiol concentration or the ratio of the blood estradiol and progesterone blood concentrations.

Adult↗
PubMedDate not supplied

[Detection of anti-HCV antibodies in patients on long-term hemodialysis].

Hepatitis C virus (HCV) infection is highly prevalent among chronic dialysis patients and is the most common cause of chronic liver disease. Ninety six patients on chronic hemodialysis in our institute of transfusiology at the Military Medical Academy were evaluated for the presence of HCV infection. There was a significant relationship between presence of anti-HCV antibodies and number of blood transfusion received by examined patients. We concluded that hepatitis C is a common problem among patients on chronic hemodialysis in our institution: HCV infection is proved in about 48.95% of all patients on hemodialysis.

Adult↗
PubMedDate not supplied

[The role of nutritional factors in pre-eclampsia and eclampsia].

Preeclampsia and eclampsia are very important health problems because they are the main contributors to maternal and perinatal morbidity and mortality. These disorders are unique in pregnancy and are characterized by oedema, proteinuria and hypertension. they occur in 0.5% to 30% of all pregnancies, primarily in primigravidas, after the 20-th week of gestation. Preeclampsia and eclampsia are diseases of undetermined cause. Many different factors might play an important role in the development of these diseases. One of them is nutrition. Recent studies have emphasized the possible role of general nutritional deficiency or imbalance of several specific nutrients in the aetiology of the disease. Deficiency of a variety of nutrients has been reported in patients with preeclampsia. The obtained results are contradictory and further study is necessary. Nevertheless, some evidence is highly suggestive of a relationship between nutritional status and the onset or progress of the disease. The article reviews the study that correlates the role of several nutritional elements with the pathophysiology of preeclampsia and eclampsia: proteins, lipids, calcium, vitamin D, sodium, magnesium and zinc. The evidence that supports or rejects the role of each of these nutrients is presented. In this way a guideline for general nutritional counseling in the prenatal period that will promote a healthier pregnancy, is offered.

Eclampsia↗
PubMedDate not supplied

[Health implications of obesity].

The high prevalence of obesity in our society makes obesity a major and increasing health hazard. Extensive observations pointed out a connection of obesity with a variety of illnesses. The evidence shows that obesity is a major contributor to the high prevalence of cardiovascular diseases, diabetes, hypertension, dyslipidaemia, gallstone disease, osteoarthritis and hyperuricaemia in the general population. Obesity also appears to be a contributor to cancers of the colon, prostate and rectum in men and breast, ovary, uterus and biliary tract in women. Hormonal abnormalities tend to occur in both obese men and women. Obese women have menstrual irregularities more often than nonobese. Obese persons tend to have reduced pulmonary function compared with nonobese. Although there are many unresolved issues, weight control is necessary for avoiding and reducing health implications of obesity. More information is required for controlling obesity and its consequences, prior to recommending a dietary advice and treatment.

Humans↗