[Carboplatin, VP-16 in epithelial ovarian cancer--initial experiences].
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Antineoplastic Combined Chemotherapy Protocols↗
Biomedical subjects
N Vavra
Publications and source records attributed to N Vavra.
[Surgical gynecologic interventions in females over 75 years of age].
In a retrospective analysis of 181 gynaecological operations performed in women older than 75 years the authors examined whether surgery had been meaningful and useful. Malignancy was established histologically in 50.3% of the cases, whereas in 49.7% benign diseases had led to an operation. Postoperative morbidity was 7.73% and depended on the magnitude of the procedure as well as on the diagnosed status of the histological findings. The mortality was 0.55%. Because of this low complication rate under appropriate internal and intensive care, surgery is recommended even in elderly women, if medical indication necessitates an invasive diagnostic or therapeutic procedure.
Aged↗
[Cervix carcinoma in pregnancy].
In this retrospective study we discuss 12 cases of cervical cancer diagnosed during pregnancy. At the time of diagnosis of cervical cancer 11/12 patients were older than 29 years. According to FIGO 3/12 cases were in stage Ia1 cervical carcinoma and 9/12 in stage Ib. After a follow up of at least 35 months no recurrence occurred. We believe, that pregnancy has no negative effect on prognosis of cervical cancer.
Adult↗
Influence of delayed diagnosis on established prognostic factors in endometrial cancer.
To evaluate the influence of delayed diagnosis on prognostic factors in endometrial cancer, we conducted a retrospective chart analysis based on the data of 116 postmenopausal patients with FIGO stage I-IV endometrial carcinoma. The interval from the first episode of post-menopausal vaginal bleeding to definitive, histological diagnosis (bleeding interval) was compared with tumor stage and various histomorphologic features in endometrial cancer. The mean bleeding interval was 12.7 +/- 17.8 weeks in 74 patients with FIGO stage IA, IB endometrial carcinoma and 35.2 +/- 69.3 weeks in 42 patients with stage IC-IV disease (t-test, p: 0.011). FIGO stage IA, IB disease was diagnosed in 23/26 (88%) patients with a bleeding interval <4 weeks, and in 22/34 (64%) and 29/56 (51%) patients with bleeding intervals of 4-8 weeks and >8 weeks, respectively (Chi-square 10.358, p=0.006). The correlation with histologic grade, lymph-node status, vessel invasion and histologic subtypes did not reach statistical significance. Our data confirm the clinical impression that postmenopausal vaginal bleeding is an early symptom in patients with endometrial cancer, and that advanced disease in the majority of cases might come from delayed diagnosis in women with poor compliance.
Aged↗