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Biomedical subjects

N Von Wowern

Publications and source records attributed to N Von Wowern.

10 recordsLinked to original sources
PubMed2000

Cherubism: a 36-year long-term follow-up of 2 generations in different families and review of the literature.

OBJECTIVE: To clarify the relationships between the varying clinical or radiographic features of cherubism. STUDY DESIGN: Nonparametric statistics were used in a long-term follow-up of 18 patients through 2 generations from 6 Danish families. RESULTS: The radiographic grade of cherubism was significantly related to sex, maximal buccal bone expansion, course of cherubism, and number of aplasia or ectopic impacted teeth, but it was not related to families. Normal dentition in nonaffected regions was present or was obtained in 14 of 14 patients (age, >14 years). Surgical treatment did not provoke growth of lesional tissue in 22 of 22 cases. Radiographically, the bone structure in the lesional areas was related to age in all grades of cherubism: new bone formation in radiolucent areas (age, >20 years), normal bone structure with multilocular sketches (age, 32 to 39 years), and completely normal bone structure (age, >41 years), also found in 7 of 7 carriers of cherubism (age, >32 years). CONCLUSIONS: This group analysis verifies the knowledge of cherubism previously based on cumulative reviews of findings in single-family and case reports.

Adolescent↗
PubMed1982

Microradiographic and histomorphometric indices of mandibles for diagnosis of osteopenia.

Mandibular autopsy specimens of 100 Danish subjects without known systemic diseases were obtained. Microradiograms of 100-micrometer-thick undemineralized vertical buccolingual grounds cross-sections and these sections, stained with basic fuchsin, were used. Microradiographic and histologic readings of bone turnover foci on Haversian canal and endosteal-trabecular surfaces were compared and combined. The analyses show the following. 1) number/area Haversian canals with bone formation and resorption foci and total of Haversian canals are reproducible and representative measures for bone turnover, while estimation of % bone turnover surfaces on periosteal and endosteal-trabecular surfaces in biopsies of mandibles has no diagnostic value. 2) Percentage of bone mass and mean cortical width in standard locality indicate the level in group of mandibles. 3) the cortical variables of bone turnover are sex independent; number/area Haversian canals with resorption foci is age independent; number/area Haversian canals with bone formation foci, total of Haversian canals and percentage of subendosteal (Haversian canals + marrow spaces) are increased with age.

Adult↗
PubMed1979

Age differences in cortical width of mandibles determined by histoquantitation.

A study was carried out to develop a histomorphometric method for indication of individual level of cortical width (MCW) and absolute cortical bone mass (MCW X % bone mass in mm3/mm2 bone surface) in the mandibular body and to demonstrate possible differences as to site, side, state of dentition, sex and age. The material consisted of autopsy specimens of mandibles. Microradiograms of 100-microns-thick buccolingual ground sections were used. An electronic point-counting system (Leitz-Classimat) was used for determination of MCW. The values for percentage of cortical bone mass have been given in previous studies. The analysis indicates that: 1) a reproducible measure for MCW in micron and absolute bone mass in a standard site can be obtained; 2) MCW in other sites of mandibular cortex deviates from that of standard site, which is why the same site has to be used in interindividual analysis; 3) MCW and absolute bone mass in the standard site are independent of side, state of dentition and sex, but show age-related decreases, while 4) the lingual cortex is unsuitable for interindividual analysis of MCW.

Adult↗
PubMed1977

Juvenile periodontitis: skeletal bone mineral content.

No analysis of the skeletal bone mineral content in patients with juvenile periodontitis seems to be available. The purpose of the present analysis, therefore, was to determine, on the basis of estimation of the skeletal bone mineral content (BMC), if an osteopenia is present in patients with juvenile periodontitis. The material consisted of 30 subjects without known systemic diseases: one group of 15 patients with juvenile periodontitis and a control group of 15 subjects with normal periodontal conditions. Test- and control subjects were paired according to sex, age, height, and weight. Each group comprised four men and 11 women aged 18-31 years. The bone mineral content (BMC) was estimated by gamma-ray photon absorptiometry of both forearms, expressed (in arbitrary units) as the mean value of 6 scans of each forearm. No significant differences were found between the total average of the 6 scans from right and left forearms or between the total and mean value for BMC in the test- and in the control group. Conclusively, the analysis shows that the BMC values lie within normal limits in patients with juvenile periodontitis. Therefore, a generalized osteopenia does not seem to be a contributory factor in this disease.

Adult↗