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Biomedical subjects

N W Everson

Publications and source records attributed to N W Everson.

5 recordsLinked to original sources
PubMed1979

The reversal of surgically induced reticuloendothelial depression.

The function of the reticuloendothelial (RE) system may be depressed by surgical operation. As this system is an important defence mechanism against tumour growth and metastasis, it would be an advantage if this depression could be prevented by the administration of a suitable agent. The agents studied in this case were levamisole, Corynebacterium parvum (C. parvum) and glucan. As a measure of RE function a carbon clearance test was performed in rats, 1 hr after partial colectomy, animals having received pre-operative treatment with one of these substances. The results show that operation produced a significant fall in clearance (P less than 0.001). Both C. parvum and glucan were very effective in preventing any fall of clearance following operation (P less than 0.01). Both of these produced marked RE stimulation and values in animals given these agents remained above control values even after surgery. Levamisole had some effect in preventing the RE depression (P less than 0.02), but was not as effective as either C. parvum or glucan.

Animals↗
PubMed1977

Wound infection following appendicectomy: the effect of extraperitoneal wound drainage and systemic antibiotic prophylaxis.

The value of extraperitoneal wound drainage and a 3-day course of prophylactic systemic cephaloridine used both separately and together have been assessed in a prospective controlled randomized trial involving 246 patients undergoing appendicectomy at the Leicester Royal Infirmary. Extraperitoneal wound drainage was shown to reduce significantly the incidence of postoperative wound infection in patients with a gangrenous or perforated appendix (P less than 0-025). Prophylactic cephaloridine significantly reduced the overall incidence of wound infection (P less than 0-02) and was also effective when the appendix was gangrenous or perforated (P less than 0-01). A highly significant reduction in wound infection was achieved when the appendix was gangrenous or perforated by the addition of wound drainage to the antibiotic regimen (P less than 0-001).

Adolescent↗
PubMed1977

The reversal of established enhancement in rat cardiac allografts.

Established enhancement in rat cardiac allografts was challenged in a variety of ways in an attempt to provoke rejection. Incompatible skin grafts, injections of sensitised lymphocytes, and the administration of the macrophage-stimulating agent Corynebacterium parvum proved ineffective. However, levamisole, which stimulates both macrophages and sensitised lymphocytes, caused rejection in four of a group of six AS rats bearing enhanced (August X AS)F1 hybrid heart allografts. A combination of C. parvum and levamisole provoked rejection in all four animals in which it was used. The results suggest that an increased activity of both lymphocytes and macrophages is required to break established enhancement.

Animals↗