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Biomedical subjects

N W James

Publications and source records attributed to N W James.

2 recordsLinked to original sources

A residency-based information system.

The medical literature has grown to an unmanageable size, and we need to develop information systems that provide better accessibility. An internal medicine residency program is an ideal setting for developing a system in which articles are screened for usefulness in clinical decision making and organized to be rapidly accessible and relatively inexpensive to use. In our residency training program, we use clinical problem-solving, journal club article review, and teaching conference preparation to generate appropriate articles from PAPERCHASE (MEDLINE) database searches. With the chief resident supervising the process, articles are then selected and organized in a computerized article file. The software program, Reference Manager (Research Information Systems, Inc., Encinitas, California), stores article citations and supports searches using standard, medical subject heading vocabulary key words. In an 18-month period, residents have collected more than 1800 references appropriate to clinical decision making and have established an article file that is now used daily as a medical information source.

Abstracting and Indexing

Determination of anaerobic threshold by ventilatory frequency.

Detection of anaerobic threshold (AT) requires either invasive techniques or expensive gas analyzers and somewhat complicated procedures. The purpose of this study was to determine if ventilatory frequency (f) could be used to detect AT. Thirteen (seven females) healthy, non-smoking, physically active adults (21-44 years) volunteered to perform progressive cycle exercise. A protocol of either 22.5- or 45-W increments every 2 min was used according to the subject's weight and fitness to assure steady state. Expiratory gas was measured using a computerized breath-by-breath system. Mean values of oxygen uptake (VO2, 1.min-1), ventilation (VE, 1.min-1), and f(br.min-1) were calculated each min. Peak VO2 ranged from 24.8 to 58.9 ml.kg-1.min with a group mean (+/- SD) of 45.1 +/- 11.6 ml.kg-1.min. Mean (+/- SD) VO2 at AT, as determined by disproportionate increase of VE, was 2.11 +/- 0.57 1.min-1. Mean (+/- SD) VO2 at the point of disproportionate increase of f was 2.09 +/- 0.58 1.min-1. A significant (P less than 0.05) correlation (r = 0.834) was found between the point of disproportionate increase in f and that of VE for individual data. A Student's t test indicated there was no significant difference in mean VO2 at AT. It was concluded that AT could be detected by f in healthy, physically active adults, thus providing a simplified and less expensive alternative method. This finding may have implications with regard to establishing and monitoring exercise intensity.

Adult