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Biomedical subjects

N W Knuckey

Publications and source records attributed to N W Knuckey.

41 records · Page 3Linked to original sources
PubMed1979

Thoracic outlet syndrome secondary to childhood poliomyelitis.

2 women with acute anterior poliomyelitis affecting the upper limb girdles in early childhood later developed thoracic outlet syndromes, 1 of them bilaterally. It is thought that the poliomyelitis was a contributory factor in each case by allowing undue descent of the shoulder girdles, although cervical ribs were also present in the second case. This association had not been recorded previously. Both patients obtained substantial relief from anterior scalenotomy, indicating that previous involvement of the shoulder girdle by poliomyelitis does not negate the efficacy of this operative procedure.

Acute Disease↗
PubMed1979

Familial trigeminal and glossopharyngeal neuralgia.

A family incorporating 2 interesting variants of trigeminal and glossopharyngeal neuralgia is presented. The familial occurrence of these cranial neuralgias spanning 3 generations is very unusual. In the case of glossopharyngeal neuralgia it has not been documented previously. Furthermore, the coincidence of trigeminal and glossopharyngeal neuralgia in the same person is quite exceptional, despite the anatomical contiguity of the sensory territories of the fifth and ninth cranial nerves. These features suggest firstly that there must be an important constitutional factor in the aetiology of the cranial neuralgia, and secondly that in many cases there is a centronuclear rather than cranial nerve ganglionic pathogenesis of the pain.

Adult↗
PubMedDate not supplied

Regional cerebral blood flow utilizing the gamma camera and xenon inhalation: reproducibility and clinical applications.

A modified collimator and standard gamma camera have been used to measure regional cerebral blood flow following inhalation of radioactive xenon. The collimator and a simplified analysis technique enables excellent statistical accuracy to be achieved with acceptable precision in the measurement of grey matter blood flow. The validity of the analysis was supported by computer modelling and patient measurements. Sixty-one patients with subarachnoid haemorrhage, cerebrovascular disease or dementia were retested to determine the reproducibility of our method. The measured coefficient of variation was 6.5%. Of forty-six patients who had a proven subarachnoid haemorrhage, 15 subsequently developed cerebral ischaemia. These showed a CBF of 42 +/- 6 ml X minute-1 X 100 g brain-1 compared with 49 +/- 11 ml X minute-1 X 100 g brain-1 for the remainder. There is evidence that decreasing blood flow and low initial flow correlate with the subsequent onset of cerebral ischaemia.

Administration, Intranasal↗
PubMedDate not supplied

Subarachnoid haemorrhage: epidemiology, natural history, and surgical treatment.

We analysed 360 patients who presented with a proven subarachnoid haemorrhage during the period 1971-78. The most common cause was a cerebral aneurysm (75%), with the anterior communicating artery being the most common site for a ruptured aneurysm. Overall mortality rate before surgical intervention was 28%. During the period of study, 106 Grade 1 patients underwent direct clipping of their aneurysms; this procedure was associated with a 6.6% mortality rate. Delayed surgical intervention was associated with a lower surgical mortality rate.

Adolescent↗